High Serum Concentration of Interleukine-6 and Rank-ligand as Risk Factors for Osteoporosis in Estrogen Deficiency Post-menopausal Women

Osteoporosis in post-menopausal women is not merely due to deficient estrogenhormone production. The development of osteoporosis is due to increased boneresorption by osteoclasts. The osteoclast\u27s number and activity is controlled by activatingfactors such as IL-6 and RANK-L. The objective of this study was to determine that highIL-6 and RANK-L serum concentrations are risks for osteoporosis in estrogen deficientpost-menopausal women. The serum concentration of ß-CrossLaps (CTx) was measuredto determine bone resorption rate. This is an observational analytical study using case andcontrol design conducted at Sanglah General Hospital of Denpasar. The sample size wascalculated using the paired case-control study formula. There were 41 osteoporotic and41 non-osteoporotic (control) estrogen deficient post-menopausal women involved in thestudy.Data were analyzed by using the t-paired and McNemar tests. Mean serumconcentration of IL-6 among the osteoporotic women was significantly higher ascompared to that of the controls (3.47±1.75 pg/ml vs 2.51±1.13 pg/ml, p = 0.001). Meanserum concentration of RANK-L among the osteoporotic women was also significantlyhigher as compared to that of the controls (320.66±122.44ng/ml vs 249.94±82.41 ng/ml,p = 0.002). To qualify as risk factors for osteoporosis, the cut-off point for IL-6 was 2.17pg/ml (OR = 4, CI 95%: 1.23-14.24; p = 0.032); the cut-off point for RANK-L was275.165 ng/ml (OR = 8, CI 95%: 1.84-34.79; p = 0.001). Analysis of both high serumconcentration of IL-6 and RANK-L was associated with an odd ratio of 9 (CI 95%: 4,27-18,96, p=0,000). CTx concentration in the osteoporotic women was significantly higherthan in the controls (0.60±0.22ng/ml vs 0.46±0.16ng/ml, p = 0.004).We found that the high IL-6 and RANK-L serum concentrations were risk factorsin estrogen deficient post-menopausal women. CTx being a marker for osteoclastic boneresorption activity, increased in concentration higher in osteoporotic than in nonosteoporoticwomen. The high serum concentrations of IL-6 and RANK-L could be usedas predictors for osteoporosis in estrogen deficient post-menopausal women

Vanguard Concentration

The design, manufacture, and performance of a solar parabolic dish/stirling engine system are investigated. The commercialization of the system is discussed based on ease of fabrication, assembly, and cost effectiveness. The various components contributed from government and related industries are evaluated

The proximity-concentration tradeoff under uncertainty

In this article, we analyse the firm's choice between serving a foreign market through exports or through foreign affiliate sales in an environment characterized by country-specific shocks to the cost of production. Our model predicts that country pairs with less-correlated output fluctuations trade more, relative to affiliate sales, whereas countries with more-volatile fluctuations are served relatively more by exporters than by foreign affiliates selling abroad. Using detailed data on trade and affiliate sales, we find empirical support for our model's predictions

The Influence of Concentration Liquid Waste of Tofu Production to Daphnia SP Cultivation Biomass

A natural feed of freshwater fish as long as it depends on worms tubifex is hard to be cultivated. Daphnia sp is one of the kinds of Cladocera zooplankton to be an alternative as a natural feed for seed of fish. The liquid tofu waste generally is a problem that is going on in every regional particularly around the Kedu Residency, Central Java. The liquid waste has the nutritional value that can be used for cultivation Daphnia sp. The right concentration of liquid waste tofu to the cultivation of Daphnia sp. has not been studied. This research aimed to find out the influence of concentration out over the density of waste biomass and the visibility of morphology Daphnia sp. The experiment used Complete Randomized Design (CRD) with three treatments and three repetitions, 25:75, 50:50, dan 75:100 (TI, T2, and T3, respectively), tofu liquid waste and water. The results concluded that T3 has repercussions for the density and biomass Daphnia sp. The density of Daphnia sp. was shown by treating 75 % of liquid tofu waste with 31.33 ind L-1 on average and while biomass was 4.6 g L-1 on average. The visibility of Daphnia sp morphology was cultivated with liquid tofu waste compared with Daphnia sp. cultivated using wastewater of catfish cultivation as a control group

Universal entanglement concentration

We propose a new protocol of \textit{universal} entanglement concentration, which converts many copies of an \textit{unknown} pure state to an \textit{% exact} maximally entangled state. The yield of the protocol, which is outputted as a classical information, is probabilistic, and achives the entropy rate with high probability, just as non-universal entanglement concentration protocols do. Our protocol is optimal among all similar protocols in terms of wide varieties of measures either up to higher orders or non-asymptotically, depending on the choice of the measure. The key of the proof of optimality is the following fact, which is a consequence of the symmetry-based construction of the protocol: For any invariant measures, optimal protocols are found out in modifications of the protocol only in its classical output, or the claim on the product. We also observe that the classical part of the output of the protocol gives a natural estimate of the entropy of entanglement, and prove that that estimate achieves the better asymptotic performance than any other (potentially global) measurements.Comment: Revised a lot, especially proofs, though no change in theorems, lemmas itself. Very long, but essential part is from Sec.I to Sec IV-C. Some of the appendces are almost independent of the main bod

The Serumal Concentration of Hbsag in Patiets with Chb/hiv Co-infection Comparing with Chb Mono-infection in the Different Phases of Natural Course of Chronic Hepatitis В

The prevalence and inclination to chronization of viral hepatitis B is 3 – 5 times higher in patients with HIV-infection than in HIV-negative ones. The natural clinical course of chronic hepatitis B (CHB) in patients with HIV has the features, connected with immune suppression and mutual influence of viruses. The quantitative determination of HBsAg allows the more precise monitoring of the natural course and the dynamics of treatment of patients with CHB but these features are little studied in patients with co-infection CHB/HIV. In the work was presented the comparative analysis of the results of quantitative determination of the serumal HBsAg in 59 Patients with co-infection CHB/HIV and 60 ones with chronic hepatitis. At the study it was established, that in patients with CHB/HIV co-infection were observed the reliably higher qHBsAg levels than in HIV-negative ones both in whole and in each CHB phase that depends on the immune suppression degree and DNA level of hepatitis B virus

Thermodynamics and concentration

We show that the thermal subadditivity of entropy provides a common basis to derive a strong form of the bounded difference inequality and related results as well as more recent inequalities applicable to convex Lipschitz functions, random symmetric matrices, shortest travelling salesmen paths and weakly self-bounding functions. We also give two new concentration inequalities.Comment: Published in at http://dx.doi.org/10.3150/10-BEJ341 the Bernoulli (http://isi.cbs.nl/bernoulli/) by the International Statistical Institute/Bernoulli Society (http://isi.cbs.nl/BS/bshome.htm

Does bank concentration lead to concentration in industrial sectors?

This paper explores the effect of banking market structure on the market structure of industrial sectors. It asks whether concentration in the banking market promotes the formation of industries constituted by a few, large firms, or rather, whether it facilitates the continuous entry of new firms, thus maintaining unconcentrated market structures across industries. Theoretical arguments could be made to support either hypotethical scenario. Empirical evidence is derived from a sample of 35 manufacturing industries in 17 OECD countries, adopting a methodology that allows controlling for other determinants of industry market structure common across industries or across countries. Bank concentration is found to enhance industries' market concentration, especially in sectors highly dependent on external finance. Such effect is however weaker in countries characterized by higher overall financial development.Banking market

Predicting malting barley protein concentration

The preferred grain protein concentration (CP) of malting barley is 10.5-11.0%, but 9.5-11.5% is acceptable. It is a challenge for farmers to achieve this target with crops grown in heterogeneous fields and exposed to fluctuating weather conditions. There are also economic and environmental reasons to balance the supply of nutrients to plant requirements. This forms the basis for precision agriculture, where barley has received limited attention. The key factor for precision agriculture in malting barley is the ability to predict CP from early observations of the crop so as to control a second fertiliser application. This thesis investigates the possibility of predicting malting barley grain CP at an early stage of development and of using a second fertilisation application during growth for total nitrogen (N) adjustment. Three experiments were conducted. The first consisted of eleven field trials (1992-1994) and was used to compare broadcasting/harrowing and combi-drilling for applying full-rate fertiliser at sowing using two types of fertilisers; pure N and one also containing phosphorus (NP). The second experiment consisted of sixteen fertiliser field trials (2001-2003) and was used to examine the possibility of postponing the decision on total N. The third consisted of three evenly fertilised fields (2002-2004). In experiments 2 and 3, canopy reflectance was measured at developmental stages BBCH 32, 45 and 69. Soil macronutrients, organic matter and mechanical composition were analysed in all ex-periments. Malting barley yield was higher when fertiliser was combi-drilled into the soil and when NP fertiliser was used. Grain CP was predicted in the field (R2adj = 0.73) from soil electrical conductivity (SECa), the canopy reflection-based vegetation index (VI) TCARI/OSAVI estimated at BBCH 32 and the sum of daily maximum temperatures during anthesis and grain filling (STS). In the fertilisation trials, CP was predicted (R2adj = 0.83) by sowing day number and the VI TCARI evaluated together with solar angle at measurement. Grain yield was independent, and grain CP almost independent, of whether all fertiliser was applied at sowing or divided between sowing and BBCH 32