An evolutionary computing model for the study of within-host evolution

Evolution of an individual within another individual is known as within-host dynamics (WHD). The most common modeling technique to study WHD involves ordinary differential equations (ODEs). In the field of biology, models of this kind assume, for example, that both the number of viruses and the number of mouse cells susceptible to being infected change according to their interaction as stated in the ODE model. However, viruses can undergo mutations and, consequently, evolve inside the mouse, whereas the mouse, in turn, displays evolutionary mechanisms through its immune system (e.g., clonal selection), defending against the invading virus. In this work, as the main novelty, we propose an evolutionary WHD model simulating the coexistence of an evolving invader within a host. In addition, instead of using ODEs we developed an alternative methodology consisting of the hybridization of a genetic algorithm with an artificial immune system. Aside from the model, interest in biology, and its potential clinical use, the proposed WHD model may be useful in those cases where the invader exhibits evolutionary changes, for instance, in the design of anti-virus software, intrusion detection algorithms in a corporation’s computer systems, etc. The model successfully simulates two intruder detection paradigms (i.e., humoral detection, danger detection) in which the intruder represents an evolving invader or guest (e.g., virus, computer program,) that infects a host (e.g., mouse, computer memory). The obtained results open up the possibility of simulating environments in which two entities (guest versus host) compete evolutionarily with each other when occupying the same space (e.g., organ cells, computer memory, network

An enhanced performance model for metamorphic computer virus classification and detectioN

Metamorphic computer virus employs various code mutation techniques to change its code to become new generations. These generations have similar behavior and functionality and yet, they could not be detected by most commercial antivirus because their solutions depend on a signature database and make use of string signature-based detection methods. However, the antivirus detection engine can be avoided by metamorphism techniques. The purpose of this study is to develop a performance model based on computer virus classification and detection. The model would also be able to examine portable executable files that would classify and detect metamorphic computer viruses. A Hidden Markov Model implemented on portable executable files was employed to classify and detect the metamorphic viruses. This proposed model that produce common virus statistical patterns was evaluated by comparing the results with previous related works and famous commercial antiviruses. This was done by investigating the metamorphic computer viruses and their features, and the existing classifications and detection methods. Specifically, this model was applied on binary format of portable executable files and it was able to classify if the files belonged to a virus family. Besides that, the performance of the model, practically implemented and tested, was also evaluated based on detection rate and overall accuracy. The findings indicated that the proposed model is able to classify and detect the metamorphic virus variants in portable executable file format with a high average of 99.7% detection rate. The implementation of the model is proven useful and applicable for antivirus programs