Identifiability results for several classes of linear compartment models

Identifiability concerns finding which unknown parameters of a model can be estimated from given input-output data. If some subset of the parameters of a model cannot be determined given input-output data, then we say the model is unidentifiable. In past work we identified a class of models, that we call identifiable cycle models, which are not identifiable but have the simplest possible identifiable functions (so-called monomial cycles). Here we show how to modify identifiable cycle models by adding inputs, adding outputs, or removing leaks, in such a way that we obtain an identifiable model. We also prove a constructive result on how to combine identifiable models, each corresponding to strongly connected graphs, into a larger identifiable model. We apply these theoretical results to several real-world biological models from physiology, cell biology, and ecology.Comment: 7 figure

Identifiability of linear compartmental tree models

A foundational question in the theory of linear compartmental models is how to assess whether a model is identifiable -- that is, whether parameter values can be inferred from noiseless data -- directly from the combinatorics of the model. We completely answer this question for those models (with one input and one output) in which the underlying graph is a bidirectional tree. Such models include two families of models appearing often in biological applications: catenary and mammillary models. Our proofs are enabled by two supporting results, which are interesting in their own right. First, we give the first general formula for the coefficients of input-output equations (certain equations that can be used to determine identifiability). Second, we prove that identifiability is preserved when a model is enlarged in specific ways involving adding a new compartment with a bidirected edge to an existing compartment.Comment: 32 page