Explainable, Domain-Adaptive, and Federated Artificial Intelligence in Medicine

Artificial intelligence (AI) continues to transform data analysis in many domains. Progress in each domain is driven by a growing body of annotated data, increased computational resources, and technological innovations. In medicine, the sensitivity of the data, the complexity of the tasks, the potentially high stakes, and a requirement of accountability give rise to a particular set of challenges. In this review, we focus on three key methodological approaches that address some of the particular challenges in AI-driven medical decision making. (1) Explainable AI aims to produce a human-interpretable justification for each output. Such models increase confidence if the results appear plausible and match the clinicians expectations. However, the absence of a plausible explanation does not imply an inaccurate model. Especially in highly non-linear, complex models that are tuned to maximize accuracy, such interpretable representations only reflect a small portion of the justification. (2) Domain adaptation and transfer learning enable AI models to be trained and applied across multiple domains. For example, a classification task based on images acquired on different acquisition hardware. (3) Federated learning enables learning large-scale models without exposing sensitive personal health information. Unlike centralized AI learning, where the centralized learning machine has access to the entire training data, the federated learning process iteratively updates models across multiple sites by exchanging only parameter updates, not personal health data. This narrative review covers the basic concepts, highlights relevant corner-stone and state-of-the-art research in the field, and discusses perspectives.Comment: This paper is accepted in IEEE CAA Journal of Automatica Sinica, Nov. 10 202

ART Neural Networks: Distributed Coding and ARTMAP Applications

ART (Adaptive Resonance Theory) neural networks for fast, stable learning and prediction have been applied in a variety of areas. Applications include airplane design and manufacturing, automatic target recognition, financial forecasting, machine tool monitoring, digital circuit design, chemical analysis, and robot vision. Supervised ART architectures, called ARTMAP systems, feature internal control mechanisms that create stable recognition categories of optimal size by maximizing code compression while minimizing predictive error in an on-line setting. Special-purpose requirements of various application domains have led to a number of ARTMAP variants, including fuzzy ARTMAP, ART-EMAP, Gaussian ARTMAP, and distributed ARTMAP. ARTMAP has been used for a variety of applications, including computer-assisted medical diagnosis. Medical databases present many of the challenges found in general information management settings where speed, efficiency, ease of use, and accuracy are at a premium. A direct goal of improved computer-assisted medicine is to help deliver quality emergency care in situations that may be less than ideal. Working with these problems has stimulated a number of ART architecture developments, including ARTMAP-IC [1]. This paper describes a recent collaborative effort, using a new cardiac care database for system development, has brought together medical statisticians and clinicians at the New England Medical Center with researchers developing expert systems and neural networks, in order to create a hybrid method for medical diagnosis. The paper also considers new neural network architectures, including distributed ART {dART), a real-time model of parallel distributed pattern learning that permits fast as well as slow adaptation, without catastrophic forgetting. Local synaptic computations in the dART model quantitatively match the paradoxical phenomenon of Markram-Tsodyks [2] redistribution of synaptic efficacy, as a consequence of global system hypotheses.Office of Naval Research (N00014-95-1-0409, N00014-95-1-0657