Unimpaired Neuropsychological Performance and Enhanced Memory Recall in Patients with Sbma: A Large Sample Comparative Study.

Peculiar cognitive profile of patients with SBMA has been described by fragmented literature. Our retrospective study reports the neuropsychological evaluations of a large cohort of patients in order to contribute towards the understanding of this field. We consider 64 neuropsychological evaluations assessing mnesic, linguistic and executive functions collected from 2013 to 2015 in patients attending at Motor Neuron Disease Centre of University of Padova. The battery consisted in: Digit Span forwards and backwards, Prose Memory test, Phonemic Verbal fluency and Trail making tests. ANCOVA statistics were employed to compare tests scores results with those obtained from a sample of healthy control subjects. Multiple linear regressions were used to study the effect on cognitive performance of CAG-repeat expansion, the degree of androgen insensitivity and their interaction to cognitive performance. Statistical analyses did not reveal altered scores in any neuropsychological tests among those adopted. Interestingly, patients performed significantly better in the Prose Memory test's score. No relevant associations were found with genetic, hormonal or clinical patients' profile. Results inconsistent with previous studies have been interpreted according to the phenomenon of somatic mosaicism. We suggest a testosterone-related and the mood state-dependant perspectives as two possible interpretations of the enhanced performances in the Prose Memory test. Further studies employing more datailed tests batteries are encouraged

Andy Clark and his Critics

In this volume, a range of high-profile researchers in philosophy of mind, philosophy of cognitive science, and empirical cognitive science, critically engage with Clark's work across the themes of: Extended, Embodied, Embedded, Enactive, and Affective Minds; Natural Born Cyborgs; and Perception, Action, and Prediction. Daniel Dennett provides a foreword on the significance of Clark's work, and Clark replies to each section of the book, thus advancing current literature with original contributions that will form the basis for new discussions, debates and directions in the discipline

Understanding the Cognitive Impact of Emerging Web Technologies: A Research Focus Area for Embodied, Extended and Distributed Approaches to Cognition

Alongside existing research into the social, political and economic impacts of the Web, there is also a need to explore the effects of the Web on our cognitive profile. This is particularly so as the range of interactive opportunities we have with the Web expands under the influence of a range of emerging technologies. Embodied, extended and distributed approaches to cognition are relevant to understanding the potential cognitive impact of these new technologies because of the emphasis they place on extra-neural and extra-corporeal factors in the shaping of our cognitive capabilities at both an individual and collective level. The current paper outlines a number of areas where embodied, extended and distributed approaches to cognition are useful in understanding the impact of emerging Web technologies on future forms of both human and machine intelligence

Pragmatic language disorder in Parkinson's disease and the potential effect of cognitive reserve

It is known that patients with Parkinson\u2019s Disease (PD) may show deficits in several areas of cognition, including speech and language abilities. One domain of particular interest is pragmatics, which refers to the capacity of using language in context for a successful communication. Several studies showed that some specific aspects of pragmatics \u2013 both in production and in comprehension \u2013 might be impaired in patients with PD. However, a clear picture of pragmatic abilities in PD is still missing, as most of the existing studies focused on specific aspects of the pragmatic competence rather than on sketching a complete pragmatic profile. Moreover, little is known on the potential role of protective factors in compensating the decline of communicative skills as the disease progresses. The present study has two aims: (1) to provide a complete picture of pragmatic abilities in patients with PD, by using a comprehensive battery (Assessment of Pragmatic Abilities and Cognitive Substrates, APACS) and by investigating the relationship with other aspects of cognitive functioning (e.g., working memory and Theory of Mind) and (2) to investigate whether Cognitive Reserve, i.e., the resilience to cognitive impairment provided by life experiences and activities, may compensate for the progressive pragmatic deficits in PD. We found that patients with PD, compared to healthy matched controls, had worse performance in discourse production and in the description of scenes, and that these impairments were tightly correlated with the severity of motor impairment, suggesting reduced intentionality of engaging in a communicative exchange. Patients with PD showed also an impairment in comprehending texts and humor, suggesting a problem in inferring from stories, which was related to general cognitive impairment. Notably, we did not find any significant difference between patients and controls in figurative language comprehension, a domain that is commonly impaired in other neurodegenerative diseases. This might be indicative of a specific profile of pragmatic impairment in patients with PD, worth of further investigation. Finally, Cognitive Reserve measures showed a high degree of association with pragmatic comprehension abilities, suggesting that the modification of life-styles could be a good candidate for compensating the possible problems in understanding the pragmatic aspects of language experienced by patients with PD

Personalised trails and learner profiling within e-learning environments

This deliverable focuses on personalisation and personalised trails. We begin by introducing and defining the concepts of personalisation and personalised trails. Personalisation requires that a user profile be stored, and so we assess currently available standard profile schemas and discuss the requirements for a profile to support personalised learning. We then review techniques for providing personalisation and some systems that implement these techniques, and discuss some of the issues around evaluating personalisation systems. We look especially at the use of learning and cognitive styles to support personalised learning, and also consider personalisation in the field of mobile learning, which has a slightly different take on the subject, and in commercially available systems, where personalisation support is found to currently be only at quite a low level. We conclude with a summary of the lessons to be learned from our review of personalisation and personalised trails

Cognitive Reserve and Its Effect in Older Adults on Retrieval of Proper Names, Logo Names and Common Nouns

Previous studies showed that high Cognitive Reserve (CR, years of education and experience and knowledge acquired in life) is correlated with language proficiency as measured with vocabulary size, verbal analogy, and semantic processing. The aim of the present study is to investigate the relationship between CR and the ability in retrieving different categories of words: Proper Names, Logo Names, and Common Nouns. The hypothesis is that CR contributes more in retrieving Common Nouns and Logo Names which are highly semantically interconnected, than retrieving Proper Names which are pure referring expressions. Forty-six Italian healthy older adults underwent the Montreal Cognitive Assessment (MoCA) and their performances spanned from low to high global cognitive profile. They were also administered a picture naming task for Proper Names, Logo Names and Common Nouns. Latency and Accuracy were recorded. CR was measured with the Cognitive Reserve Index (CRI) questionnaire which provides a measure of education, working time activities, and leisure time activities. Participants were significantly faster and more accurate in name retrieval when CR was high. CRI and MoCA as interaction terms predicted naming Latency with a stronger effect of CRI when the global cognitive profile was in the low range. The effect of CRI on Accuracy was lower for Proper Names than for Common Nouns and Logo Names, which did not differ from each other. Our results show that name retrieval Accuracy can be predicted by CR, significantly more in the case of Logo Names and Common Nouns than in the case of Proper Names. As Proper Names have scarce semantic interconnections and are arbitrarily assigned to unique individuals, they are not much influenced by CR. Although Logo Names are also arbitrarily assigned to their bearers, they can be conceptually categorized and thus influenced by reserve. The weak relationship between Proper Names and CR might suggest a proper name task as a useful tool to detect early signs of dementia, in particular for persons with high CR

Thinking about thinking after Munro: the contribution of cognitive interviewing to child-care social work supervision and decision-making practices

There has been a recurrent recognition in inquiry reports following high-profile deaths of children known to welfare services of shortcomings in social workers' analytical and assessment skills. There is an urgent need to explore what might help supervisors and practitioners ‘think about their thinking’. This paper draws on cognitive interviewing (CI) and examines its applicability/transferability to the professional domain of child-care social work supervision. Focusing on how practitioners make sense of their practice, this approach homes in on cognitive understandings but, in so doing, heightens practitioners' awareness of the emotional and affective dimensions of practice and of their thinking. The integration of cognitive and affective ways of knowing resonates with psycho-socially informed ideas about the interrelationship between thinking and feeling and the importance of emotional containment for effective thinking. This paper suggests that combining the psychological underpinnings of CI with psycho-socially informed concepts, such as containment, creates a more robust and holistic theoretical framework for supporting the application of CI in practice. The paper proposes that the adoption of a cognitive andaffective approach to supervisory practice has considerable potential for enhancing practitioners' critical thinking skills and decision-making capabilities, to the benefit of the children and families with whom they work

The relationships between vitamin K and cognition: a review of current evidence

Vitamin K is a fat-soluble nutrient discovered in 1935 and its role in blood coagulation has been thoroughly explored. In recent years, studies conducted in vitro and on animals highlighted vitamin K involvement in brain cells development and survival. In particular, vitamin K seems to have an antiapoptotic and anti-inflammatory effect mediated by the activation of Growth Arrest Specific Gene 6 and Protein S. Moreover, this vitamin is involved in sphingolipids metabolism, a class of lipids that participate in the proliferation, differentiation, and survival of brain cells. An altered expression in sphingolipids profile has been related to neuroinflammation and neurodegeneration. This review stems from a growing interest in the role of vitamin K in brain functions, especially in cognition, also in view of an expected increase of prevalence of Alzheimer's disease and other forms of dementia. It collects recent researches that show interesting, even though not definitive, evidence of a direct correlation between vitamin K levels and cognitive performance. Moreover, vitamin K antagonists, used worldwide as oral anticoagulants, according to recent studies may have a negative influence on cognitive domains such as visual memory, verbal fluency and brain volume. The aim of this review is to analyze the evidence of clinical studies carried out up to date on the relationship between vitamin K intake and cognitive performances. The involvement of vitamin K antagonists (VKAs) in declining cognitive performances is also addressed separately

The Relationship between Iranian EFL High School Students’ Multiple Intelligence Scores and Their Use of Learning Strategies

According to the theory of multiple intelligences (MI) propounded by Gardner (1983, 1999a, 1999b), each individual has a multitude of intelligences that are quite independent of each other and each individual has a unique cognitive profile. Having access to the MI profiles and learning strategies of learners could help the teachers in planning activities to connect both strategies and students’ talents and provide students with the best possible instruction. Thus, this study attempts to find out the relationship between the MI profiles and language learning strategies used by Iranian EFL high school students. Two hundred and twenty-nine students (121 males, 108 females) participated in the study. The instruments used to elicit information for this study were McKenzie’s (1999) MI inventory and the Strategy Inventory for Language Learning (SILL) Questionnaire. The findings revealed that there is a low, positive correlation between the two variables of MI and learning strategies, r = 0.24. In addition, it was found that there is a low, positive correlation between MI and different strategy types. The highest correlation was seen between meta-cognitive strategies and MI, followed by compensation and cognitive strategies. Furthermore, the findings reveal that Iranian students mostly use meta-cognitive strategies followed by social strategies