Population variability in animal health: Influence on dose-exposure-response relationships: Part II: Modelling and simulation

During the 2017 Biennial meeting, the American Academy of Veterinary Pharmacology and Therapeutics hosted a 1‐day session on the influence of population variability on dose‐exposure‐response relationships. In Part I, we highlighted some of the sources of population variability. Part II provides a summary of discussions on modelling and simulation tools that utilize existing pharmacokinetic data, can integrate drug physicochemical characteristics with species physiological characteristics and dosing information or that combine observed with predicted and in vitro information to explore and describe sources of variability that may influence the safe and effective use of veterinary pharmaceuticals

online clearance system (OC System)

The purpose of this project is to design a system for UTP Security Department, fnformation Resource Centre Department and finance Department specifically for the administration of students and staffs' administration management. The system will be web - based applications that can be executed using normal web browser for inter - platform capabilities. The project is divided into two terms, first the research on clearance system for final semester student and second development on the Online Clearance System (OC System). Research on the OC System will be based on the problem statement and objective of the project while the research for the current clearance system for fmal semester at UTP is the support idea for the project. This document also gives further information about the system in the literature review/theory section. This section includes the features of the system, the benefits from using the system, and the data flow diagram of the intended system. Part of the Final Year Project, student manage to get known with the business environment on how they manage their database, clearance system and the performance of the staff. In using Online Clearance System (OC System) give the best solution for the staff as the database plays an important asset for the staff. l would use distributed database in my system.A distributed database is a database that is under the control of a central database management system in which storage devices are not all attached to a common CPU. It may be stored in multiple computers located in the same physical location, or may be dispersed over a network of interconnected computers. Collections of data (eg. in a database) can be distributed across multiple physical locations. A distributed database is distributed into separate partitions/fragments. Each partition/fragment of a distributed database may be replicated (ie. redundant fail-overs, R.AlD fike)

Novel Hitch Cargo Cart

This document presents the engineering design process used to develop, manufacture, and test a new and improved iteration of a hitch cart prototype. This process was performed by a team of four mechanical engineering seniors as part of California Polytechnic State University, San Luis Obispo’s senior design pathway. The goal of this project was to develop a sturdy and reliable iteration of our sponsor’s hitch cart prototype, that integrated the functionality of a vehicle hitch cargo platform and that of a height adjustable cargo cart into a single streamlined and easy to use product. This design could be used by tradesmen, and outdoor enthusiast to not only transport heavy equipment and cargo to where they’re going, but also offer a form of easily maneuverable cargo transportation once they get there. While similar designs currently exist, none incorporate an adjustable height platform and are either difficult to attach and remove from the vehicle, have a low loading capacity and small storage footprint, or are designed for small vehicle applications. Based on preliminary testing, our design appears to be a promising product that is robust and addresses many of the limitations of competing designs. Future refinement of the design can be done to further improve user experience and increase the potential for use on a wider range of vehicle sizes and hitch classes

Family migration to Australia

This paper reviews the thinking behind Australia\u27s family migration program and the aspects considered when planning its size and composition each year. Executive summary: In contrast to the United States of America, the Australian Government has steadily prioritised skilled migration within Australia’s permanent Migration Program, with proportionally fewer family places available. The current Coalition Government affirms that the focus of the immigration program is primarily economic, not social, and has promised to further prioritise skilled migration over the years ahead. Whilst planning levels clearly depict skilled migration at around two thirds of the overall Migration Program, it is important to acknowledge that over fifty percent of the Skill Stream is in fact comprised of family (secondary visa holders). In this light, family migration still remains at the very heart of Australia’s Migration Program. Although parts of the Family Stream are seen to be a net cost to the Commonwealth budget, overall, family migration presents a net gain both economically and socially. Family structures are particularly important in attracting or keeping skilled migrants—an issue of particular significance in regional areas. A strong grasp of the English language is perceived as one of the best ways to ensure family migrants embrace Australian society and culture

Quality of fixed dose artemether/lumefantrine products in Jimma Zone, Ethiopia

Background: Malaria caused by Plasmodium vivax and Plasmodium falciparum is among the major public health problems in most endemic areas of the world. Artemisinin-based combination therapy (ACT) has been recommended as a first-line treatment for uncomplicated Plasmodium falciparum malaria almost in all endemic regions. Since ineffectively regulated medicines in resource limited settings could favour infiltration of poor quality anti-malarial medicines into pharmaceutical supply chain and jeopardize a positive treatment outcome, regular monitoring of the quality of anti-malarial medicines is critical. Thus, the aim of this study was to assess the quality of fixed dose combination (FDC) artemether (ART)/lumefantrine (LUM) tablets available in Jimma zone, Ethiopia. Methods: This study was conducted in Jimma zone, Ethiopia. A total of 74 samples of FDC ART/LUM (20mg ART/120mg LUM) tablets were collected from 27 public facilities. All samples were subjected to visual inspection and the relevant information was recorded. The samples were transported to Jimma University Laboratory of Drug Quality (JuLaDQ) and stored at ambient temperature (20 degrees C to 25 degrees C) until analysis. The Pharmacopoeial conform/non-conform methods and the risk-based Derringer's desirability function approach were employed to assess the pharmaceutical quality of the investigated products. Results: The visual inspection results revealed that there were no signs of falsified in the investigated products. Identification test results of samples indicated that all samples contained the stated active pharmaceutical ingredients (APIs). The results of uniformity of mass indicated that all samples complied with International Pharmacopoeial specification limits. The assay results, expressed as percent label claim (%lc) of ART (89.8 to 108.8%, meanSD=99.1 +/- 3.9%) and LUM (90.0 to 111.9%, mean +/- SD=98.2 +/- 3.8%) revealed that, all samples complied with International Pharmacopoeia acceptance specification limits (i.e. 90-110%lc), except one generic product (IPCA Laboratories Ltd., India) which contains excessive LUM (111.9 +/- 1.7%lc). The risk priority number (RPN) results revealed that assay (RPN=392) is relatively the most critical quality attribute followed by identity (RPN=280) and mass uniformity (40). Quality evaluation based on psycho-physical Harrington's scale revealed that more than 96% of samples were within the acceptable ranges (D >= 0.7-1.0). Conclusions: Both Pharmacopoeial and risk-based desirability function approaches to quality evaluation applied to the investigated products revealed that above 96% FDC ART/LUM tablets circulating in public settings of Jimma zone are of good quality

Design, Fabrication, and Implementation of Jump-Cue Testing Machine

A device for measuring the effectiveness of a jump cue performing the jump shot in the game of pool is presented. The design, build, integration, and current application of the jump-cue testing machine are described. A physical system model is described that allows for the basic actuation of the mechanical system to be established and understood. The mechanical design embodiment of the jump-cue testing machine is presented with mechanical design and realization aspects of the device emphasized. Examples of current use of the jump-cue testing machine by industry are described