Automated detection of Alzheimer disease using MRI images and deep neural networks- A review

Early detection of Alzheimer disease is crucial for deploying interventions and slowing the disease progression. A lot of machine learning and deep learning algorithms have been explored in the past decade with the aim of building an automated detection for Alzheimer. Advancements in data augmentation techniques and advanced deep learning architectures have opened up new frontiers in this field, and research is moving at a rapid speed. Hence, the purpose of this survey is to provide an overview of recent research on deep learning models for Alzheimer disease diagnosis. In addition to categorizing the numerous data sources, neural network architectures, and commonly used assessment measures, we also classify implementation and reproducibility. Our objective is to assist interested researchers in keeping up with the newest developments and in reproducing earlier investigations as benchmarks. In addition, we also indicate future research directions for this topic.Comment: 22 Pages, 5 Figures, 7 Table

Alzheimers Disease Diagnosis using Machine Learning: A Review

Alzheimers Disease AD is an acute neuro disease that degenerates the brain cells and thus leads to memory loss progressively. It is a fatal brain disease that mostly affects the elderly. It steers the decline of cognitive and biological functions of the brain and shrinks the brain successively, which in turn is known as Atrophy. For an accurate diagnosis of Alzheimers disease, cutting edge methods like machine learning are essential. Recently, machine learning has gained a lot of attention and popularity in the medical industry. As the illness progresses, those with Alzheimers have a far more difficult time doing even the most basic tasks, and in the worst case, their brain completely stops functioning. A persons likelihood of having early-stage Alzheimers disease may be determined using the ML method. In this analysis, papers on Alzheimers disease diagnosis based on deep learning techniques and reinforcement learning between 2008 and 2023 found in google scholar were studied. Sixty relevant papers obtained after the search was considered for this study. These papers were analysed based on the biomarkers of AD and the machine-learning techniques used. The analysis shows that deep learning methods have an immense ability to extract features and classify AD with good accuracy. The DRL methods have not been used much in the field of image processing. The comparison results of deep learning and reinforcement learning illustrate that the scope of Deep Reinforcement Learning DRL in dementia detection needs to be explored.Comment: 10 pages and 3 figure

Alzheimers Disease Diagnosis by Deep Learning Using MRI-Based Approaches

The most frequent kind of dementia of the nervous system, Alzheimer's disease, weakens several brain processes (such as memory) and eventually results in death. The clinical study uses magnetic resonance imaging to diagnose AD. Deep learning algorithms are capable of pattern recognition and feature extraction from the inputted raw data. As early diagnosis and stage detection are the most crucial elements in enhancing patient care and treatment outcomes, deep learning algorithms for MRI images have recently allowed for diagnosing a medical condition at the beginning stage and identifying particular symptoms of Alzheimer's disease. As a result, we aimed to analyze five specific studies focused on AD diagnosis using MRI-based deep learning algorithms between 2021 and 2023 in this study. To completely illustrate the differences between these techniques and comprehend how deep learning algorithms function, we attempted to explore selected approaches in depth

DEEP-AD: The deep learning model for diagnostic classification and prognostic prediction of alzheimer's disease

In terms of context, the aim of this dissertation is to aid neuroradiologists in their clinical judgment regarding the early detection of AD by using DL. To that aim, the system design research methodology is suggested in this dissertation for achieving three goals. The first goal is to investigate the DL models that have performed well at identifying patterns associated with AD, as well as the accuracy so far attained, limitations, and gaps. A systematic review of the literature (SLR) revealed a shortage of empirical studies on the early identification of AD through DL. In this regard, thirteen empirical studies were identified and examined. We concluded that three-dimensional (3D) DL models have been generated far less often and that their performance is also inadequate to qualify them for clinical trials. The second goal is to provide the neuroradiologist with the computer-interpretable information they need to analyze neuroimaging biomarkers. Given this context, the next step in this dissertation is to find the optimum DL model to analyze neuroimaging biomarkers. It has been achieved in two steps. In the first step, eight state-of-the-art DL models have been implemented by training from scratch using end-to-end learning (E2EL) for two binary classification tasks (AD vs. CN and AD vs. stable MCI) and compared by utilizing MRI scans from the publicly accessible datasets of neuroimaging biomarkers. Comparative analysis is carried out by utilizing efficiency-effects graphs, comprehensive indicators, and ranking mechanisms. For the training of the AD vs. sMCI task, the EfficientNet-B0 model gets the highest value for the comprehensive indicator and has the fewest parameters. DenseNet264 performed better than the others in terms of evaluation matrices, but since it has the most parameters, it costs more to train. For the AD vs. CN task by DenseNet264, we achieved 100% accuracy for training and 99.56% accuracy for testing. However, the classification accuracy was still only 82.5% for the AD vs. sMCI task. In the second step, fusion of transfer learning (TL) with E2EL is applied to train the EfficientNet-B0 for the AD vs. sMCI task, which achieved 95.29% accuracy for training and 93.10% accuracy for testing. Additionally, we have also implemented EfficientNet-B0 for the multiclass AD vs. CN vs. sMCI classification task with E2EL to be used in ensemble of models and achieved 85.66% training accuracy and 87.38% testing accuracy. To evaluate the model’s robustness, neuroradiologists must validate the implemented model. As a result, the third goal of this dissertation is to create a tool that neuroradiologists may use at their convenience. To achieve this objective, this dissertation proposes a web-based application (DEEP-AD) that has been created by making an ensemble of Efficient-Net B0 and DenseNet 264 (based on the contribution of goal 2). The accuracy of a DEEP-AD prototype has undergone repeated evaluation and improvement. First, we validated 41 subjects of Spanish MRI datasets (acquired from HT Medica, Madrid, Spain), achieving an accuracy of 82.90%, which was later verified by neuroradiologists. The results of these evaluation studies showed the accomplishment of such goals and relevant directions for future research in applied DL for the early detection of AD in clinical settings.En términos de contexto, el objetivo de esta tesis es ayudar a los neurorradiólogos en su juicio clínico sobre la detección precoz de la AD mediante el uso de DL. Para ello, en esta tesis se propone la metodología de investigación de diseño de sistemas para lograr tres objetivos. El segundo objetivo es proporcionar al neurorradiólogo la información interpretable por ordenador que necesita para analizar los biomarcadores de neuroimagen. Dado este contexto, el siguiente paso en esta tesis es encontrar el modelo DL óptimo para analizar biomarcadores de neuroimagen. Esto se ha logrado en dos pasos. En el primer paso, se han implementado ocho modelos DL de última generación mediante entrenamiento desde cero utilizando aprendizaje de extremo a extremo (E2EL) para dos tareas de clasificación binarias (AD vs. CN y AD vs. MCI estable) y se han comparado utilizando escaneos MRI de los conjuntos de datos de biomarcadores de neuroimagen de acceso público. El análisis comparativo se lleva a cabo utilizando gráficos de efecto-eficacia, indicadores exhaustivos y mecanismos de clasificación. Para el entrenamiento de la tarea AD vs. sMCI, el modelo EfficientNet-B0 obtiene el valor más alto para el indicador exhaustivo y tiene el menor número de parámetros. DenseNet264 obtuvo mejores resultados que los demás en términos de matrices de evaluación, pero al ser el que tiene más parámetros, su entrenamiento es más costoso. Para la tarea AD vs. CN de DenseNet264, conseguimos una accuracy del 100% en el entrenamiento y del 99,56% en las pruebas. Sin embargo, la accuracy de la clasificación fue sólo del 82,5% para la tarea AD vs. sMCI. En el segundo paso, se aplica la fusión del aprendizaje por transferencia (TL) con E2EL para entrenar la EfficientNet-B0 para la tarea AD vs. sMCI, que alcanzó una accuracy del 95,29% en el entrenamiento y del 93,10% en las pruebas. Además, también hemos implementado EfficientNet-B0 para la tarea de clasificación multiclase AD vs. CN vs. sMCI con E2EL para su uso en conjuntos de modelos y hemos obtenido una accuracy de entrenamiento del 85,66% y una precisión de prueba del 87,38%. Para evaluar la solidez del modelo, los neurorradiólogos deben validar el modelo implementado. Como resultado, el tercer objetivo de esta disertación es crear una herramienta que los neurorradiólogos puedan utilizar a su conveniencia. Para lograr este objetivo, esta disertación propone una aplicación basada en web (DEEP-AD) que ha sido creada haciendo un ensemble de Efficient-Net B0 y DenseNet 264 (basado en la contribución del objetivo 2). La accuracy del prototipo DEEP-AD ha sido sometida a repetidas evaluaciones y mejoras. En primer lugar, validamos 41 sujetos de conjuntos de datos de MRI españoles (adquiridos de HT Medica, Madrid, España), logrando una accuracy del 82,90%, que posteriormente fue verificada por neurorradiólogos. Los resultados de estos estudios de evaluación mostraron el cumplimiento de dichos objetivos y las direcciones relevantes para futuras investigaciones en DL, aplicada en la detección precoz de la AD en entornos clínicos.Escuela de DoctoradoDoctorado en Tecnologías de la Información y las Telecomunicacione

A Hybrid Transfer Learning Assisted Decision Support System for Accurate Prediction of Alzheimer Disease

Alzheimer's disease (AD) is the most common long-term illness in elderly people. In recent years, deep learning has become popular in the area of medical imaging and has had a lot of success there. It has become the most effective way to look at medical images. When it comes to detecting AD, the deep neural model is more accurate and effective than general machine learning. Our research contributes to the development of a more comprehensive understanding and detection of the disease by identifying four distinct classes that are predictive of AD with a high weighted accuracy of 98.91%. A unique strategy has been proposed to improve the accuracy of the imbalance dataset classification problem via the combination of ensemble averaging models and five different transfer learning models in this study. EfficientNetB0+Resnet152(effnet+res152) and InceptionV3+EfficientNetB0+Resnet50(incep+effnet+res50) models have been fine-tuned and have reached the highest weighted accuracy for multi-class AD stage classifications

Staging of Alzheimer's disease based on MRI using CNN

Early detection of chronic diseases and determining the stages of damage to the patient is considered one of the most important stages of treatment, as it helps doctors take important remedial measures that help the patient recover or reduce the risk of the disease to a minimum. Alzheimer's disease is one of the neurological diseases that lead to brain atrophy, which leads to the loss of its functions. MRI images of the brain are used to detect Alzheimer's disease, but it is difficult to determine both the stages of the disease and the amount of damage in a patient using this MRI technique. In this research, we aim to detect Alzheimer's disease in addition to determining its stage based on deep learning techniques by using a classifier that uses the convolutional neural network (CNN). In the research, magnetic resonance images of the brain were used, and the hippocampus region was extracted in assessing the amount of damage because it is the most important region in diagnosing damage to the disease and reduce the amount of data entered into the neural network, our results show an accuracy of 95% in estimating brain damage. The results of the classifier used were able to determine the amount of damage according to four stages of the disease

Alzheimer’s Disease Diagnosis Using CNN Based Pre-trained Models

Memory loss and impairment are signs of Alzheimer's disease (AD), which may also cause other issues. It has a significant impact on patients' lives and is incurable, but rapid recognition of Alzheimer's disease can be useful to initiate appropriate therapy to avoid further deterioration to the brain. Previously, Machine Learning methodswere used to detect Alzheimer's disease. In recent times, Deep Learning algorithms have become more popular for pattern recognition. This workconcentrates on the recognition of Alzheimer's disease at a preliminary phase using advanced convolutional neural network models. As the disease advances, they steadily forget everything. It is critical to detect the disease as quickly as possible. The proposed model usespre-trained models that uses magnetic resonance imaging of the brain to determine if a person has very mild, mild, moderate, or non-dementia. The models used for classification are VGG16, VGG19, and ResNet50 architectures and provide performance comparison

Alzheimer's Disease: A Survey

Alzheimer's Diseases (AD) is one of the type of dementia. This is one of the harmful disease which can lead to death and yet there is no treatment. There is no current technique which is 100% accurate for the treatment of this disease. In recent years, Neuroimaging combined with machine learning techniques have been used for detection of Alzheimer's disease. Based on our survey we came across many methods like Convolution Neural Network (CNN) where in each brain area is been split into small three dimensional patches which acts as input samples for CNN. The other method used was Deep Neural Networks (DNN) where the brain MRI images are segmented to extract the brain chambers and then features are extracted from the segmented area. There are many such methods which can be used for detection of Alzheimer’s Disease

Survey on Early Detection of Alzheimer's Disease using Different Types of Neural Network Architecture

Alzheimer’s disease is a condition that leads to, progressive neurological brain disorder and destroys cells of the brain thereby causing an individual to lose their ability to continue daily activities and also hampers their mentality. Diagnostic symptoms are experienced by patients usually at later stages after irreversible neural damage occurs. Detection of AD is challenging because sometimes the signs that distinguish AD MRI data, can be found in MRI data of normal healthy brains of older people. Even though this disease is not completely curable, earlier detection can aid in promising treatment and prevent permanent damage to brain tissues. Age and genetics are the greatest risk factors for this disease. This paper presents the latest reports on AD detection based on different types of Neural Network Architectures