The Enigmatic Canal-Associated Neurons Regulate Caenorhabditis elegans Larval Development Through a cAMP Signaling Pathway.

Caenorhabditis elegans larval development requires the function of the two Canal-Associated Neurons (CANs): killing the CANs by laser microsurgery or disrupting their development by mutating the gene ceh-10 results in early larval arrest. How these cells promote larval development, however, remains a mystery. In screens for mutations that bypass CAN function, we identified the gene kin-29, which encodes a member of the Salt-Inducible Kinase (SIK) family and a component of a conserved pathway that regulates various C. elegans phenotypes. Like kin-29 loss, gain-of-function mutations in genes that may act upstream of kin-29 or growth in cyclic-AMP analogs bypassed ceh-10 larval arrest, suggesting that a conserved adenylyl cyclase/PKA pathway inhibits KIN-29 to promote larval development, and that loss of CAN function results in dysregulation of KIN-29 and larval arrest. The adenylyl cyclase ACY-2 mediates CAN-dependent larval development: acy-2 mutant larvae arrested development with a similar phenotype to ceh-10 mutants, and the arrest phenotype was suppressed by mutations in kin-29 ACY-2 is expressed predominantly in the CANs, and we provide evidence that the acy-2 functions in the CANs to promote larval development. By contrast, cell-specific expression experiments suggest that kin-29 acts in both the hypodermis and neurons, but not in the CANs. Based on our findings, we propose two models for how ACY-2 activity in the CANs regulates KIN-29 in target cells

Evaluation of the Anchorage Coordinated Agency Network (CANS) Program

In spring 1999, the Anchorage Police Department and the Alaska Division of Juvenile Justice formed a partnership to enhance the supervision and services provided to juvenile probationers in Anchorage. Modeled after a successful program in San Diego, California, the Anchorage Coordinated Agency Network (CANS) project extended the supervision arm of the youth probation office by having Anchorage police officers make random visits to juvenile probationers. This evaluation examines the CANS program during its pilot phase, June through December 1999. The evaluation assesses whether juveniles participating in the CANS program differed from a control group of non-CANS participants with respect to new probation violations and new offenses. An effort is also made to determine the most important factors predicting program outcomes.Anchorage Police Department Alaska Division of Juvenile JusticeIntroduction / Program Overview / Related Literature / Methodology / Analysis / Summary & Discussion / Reference

Modeling of Social Transitions Using Intelligent Systems

In this study, we reproduce two new hybrid intelligent systems, involve three prominent intelligent computing and approximate reasoning methods: Self Organizing feature Map (SOM), Neruo-Fuzzy Inference System and Rough Set Theory (RST),called SONFIS and SORST. We show how our algorithms can be construed as a linkage of government-society interactions, where government catches various states of behaviors: solid (absolute) or flexible. So, transition of society, by changing of connectivity parameters (noise) from order to disorder is inferred

Parametric study of thermal storage containing rocks or fluid filled cans for solar heating and cooling, phase 2

The test data and an analysis of the heat transfer characteristics of a solar thermal energy storage bed utilizing water filled cans and standard bricks as energy storage medium are presented. This experimental investigation was initiated to find a usable heat intensive solar thermal storage device other than rock storage and water tank. Four different sizes of soup cans were stacked in a chamber in three different arrangements-vertical, horizontal, and random. Air is used as transfer medium for charging and discharge modes at three different mass flow rates and inlet air temperature respectively. These results are analyzed and compared, which show that a vertical stacking and medium size cans with Length/Diameter (L/D) ratio close to one have better average characteristics of heat transfer and pressure drop

Fisheries bioecology at the Khone Falls (Mekong River, Southern Laos)

This CD-ROM contains full database of the "Khone Fall fisheries database" and detailed analyses done in the companion report "Ecological studies of fish in the Khone Falls area (Mekong River, Southern Lao PDR).Fisheries, Ecology, Mekong River, Laos,

Extraordinary focusing of sound above a soda can array without time reversal

Recently, Lemoult et al. [Phys. Rev. Lett. 107, 064301 (2011)] used time reversal to focus sound above an array of soda cans into a spot much smaller than the acoustic wavelength in air. In this study, we show that equally sharp focusing can be achieved without time reversal, by arranging transducers around a nearly circular array of soda cans. The size of the focal spot at the center of the array is made progressively smaller as the frequency approaches the Helmholtz resonance frequency of a can from below, and, near the resonance, becomes smaller than the size of a single can. We show that the locally resonant metamaterial formed by soda cans supports a guided wave at frequencies below the Helmholtz resonance frequency. The small focal spot results from a small wavelength of this guided wave near the resonance in combination with a near field effect making the acoustic field concentrate at the opening of a can. The focusing is achieved with propagating rather than evanescent waves. No sub-diffraction-limited focusing is observed if the diffraction limit is defined with respect to the wavelength of the guided mode in the metamaterial medium rather than the wavelength of the bulk wave in air

Margaret Cans to Mr. James Meredith (3 October 1962)

https://egrove.olemiss.edu/mercorr_pro/1226/thumbnail.jp