809,043 research outputs found

    An asymptotic sampling formula for the coalescent with Recombination

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    Ewens sampling formula (ESF) is a one-parameter family of probability distributions with a number of intriguing combinatorial connections. This elegant closed-form formula first arose in biology as the stationary probability distribution of a sample configuration at one locus under the infinite-alleles model of mutation. Since its discovery in the early 1970s, the ESF has been used in various biological applications, and has sparked several interesting mathematical generalizations. In the population genetics community, extending the underlying random-mating model to include recombination has received much attention in the past, but no general closed-form sampling formula is currently known even for the simplest extension, that is, a model with two loci. In this paper, we show that it is possible to obtain useful closed-form results in the case the population-scaled recombination rate ρ\rho is large but not necessarily infinite. Specifically, we consider an asymptotic expansion of the two-locus sampling formula in inverse powers of ρ\rho and obtain closed-form expressions for the first few terms in the expansion. Our asymptotic sampling formula applies to arbitrary sample sizes and configurations.Comment: Published in at http://dx.doi.org/10.1214/09-AAP646 the Annals of Applied Probability (http://www.imstat.org/aap/) by the Institute of Mathematical Statistics (http://www.imstat.org

    Closed formula for the relative entropy of entanglement

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    The long-standing problem of finding a closed formula for the relative entropy of entanglement (REE) for two qubits is addressed. A compact-form solution to the inverse problem, which characterizes an entangled state for a given closest separable state, is obtained. Analysis of the formula for a large class of entangled states strongly suggests that a compact analytical solution of the original problem, which corresponds to finding the closest separable state for a given entangled state, can be given only in some special cases. A few applications of the compact-form formula are given to show additivity of the REE, to relate the REE with the Rains upper bound for distillable entanglement, and to show that a Bell state does not have a unique closest separable state.Comment: 7 pages, the title was modified as suggested by the PRA editor

    Instability of semi-Riemannian closed geodesics

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    A celebrated result due to Poincar\'e affirms that a closed non-degenerate minimizing geodesic γ\gamma on an oriented Riemannian surface is hyperbolic. Starting from this classical theorem, our first main result is a general instability criterion for timelike and spacelike closed semi-Riemannian geodesics on a (non)oriented manifold. A key role is played by the spectral index, a new topological invariant that we define through the spectral flow (being the Morse index truly infinite) of a path of selfadjoint Fredholm operators. A major step in the proof of this result is a em new spectral flow formula. Bott's iteration formula, introduced by author in 1956, relates in a clear way the Morse index of an iterated closed Riemannian geodesic and the so-called ω\omega-Morse indices. Our second result is a semi-Riemannian generalization of the famous Bott-type iteration formula in the case of closed (resp. timelike closed) Riemannian (resp. Lorentzian) geodesics. Our last result is a strong instability result obtained by controlling the Morse index of the geodesic and of all of its iterations.Comment: 33 pages, 2 figures. Fixed some typos and updated references. arXiv admin note: text overlap with arXiv:1705.0917

    Shadow world evaluation of the Yang-Mills measure

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    A new state-sum formula for the evaluation of the Yang-Mills measure in the Kauffman bracket skein algebra of a closed surface is derived. The formula extends the Kauffman bracket to diagrams that lie in surfaces other than the plane. It also extends Turaev's shadow world invariant of links in a circle bundle over a surface away from roots of unity. The limiting behavior of the Yang-Mills measure when the complex parameter approaches -1 is studied. The formula is applied to compute integrals of simple closed curves over the character variety of the surface against Goldman's symplectic measure.Comment: Published by Algebraic and Geometric Topology at http://www.maths.warwick.ac.uk/agt/AGTVol4/agt-4-17.abs.htm
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