14,155 research outputs found
Strategies for Early Learners
Welcome to learning about how to effectively plan curriculum for young children. This textbook will address: âą Developing curriculum through the planning cycle âą Theories that inform what we know about how children learn and the best ways for teachers to support learning âą The three components of developmentally appropriate practice âą Importance and value of play and intentional teaching âą Different models of curriculum âą Process of lesson planning (documenting planned experiences for children) âą Physical, temporal, and social environments that set the stage for childrenâs learning âą Appropriate guidance techniques to support childrenâs behaviors as the self-regulation abilities mature. âą Planning for preschool-aged children in specific domains including o Physical development o Language and literacy o Math o Science o Creative (the visual and performing arts) o Diversity (social science and history) o Health and safety âą Making childrenâs learning visible through documentation and assessmenthttps://scholar.utc.edu/open-textbooks/1001/thumbnail.jp
In Search of Chiral Molecular Superconductors: Îș-[(S,S)-DM-BEDT-TTF]2ClO4 Revisited
The relationship between chirality and superconductivity is an intriguing question. The two enantiomeric crystalline radical cation salts Îș-[(S,S)-DM-BEDT-TTF]2ClO4 and Îș-[(R,R)-DM-BEDT-TTF]2ClO4, showing Îș-type arrangement of the organic layers, are investigated in search for superconducting chiral molecular materials following a 1992 report indicating the occurrence of a superconducting transition in the former compound. While the initial interpretation is presently challenged through in-depth temperature and pressure dependent single crystal resistivity measurements combined with band structure calculations, the two chiral conductors show metal like behavior with room temperature conductivities of 10-30 S cmâ1 at ambient pressure and stabilization of the metallic state down to the lowest temperatures under moderate pressures. Moreover, their structural and theoretical investigations reveal an original feature, namely the existence of two different Îș layers with 1D and 2D electronic dimensionality, respectively, as a consequence of an interlayer charge transfer. The resistivity drop observed for one sample below 1 K and insensitive to magnetic field, possibly results from mixing in-plane and out-of-plane contributions to the measured resistance and suggests current induced charge order melting. This feature contradicts the occurrence of superconductivity in these chiral molecular conductors and leaves open the discovery of the first chiral molecular superconductors
Limit theorems for non-Markovian and fractional processes
This thesis examines various non-Markovian and fractional processes---rough volatility models, stochastic Volterra equations, Wiener chaos expansions---through the prism of asymptotic analysis.
Stochastic Volterra systems serve as a conducive framework encompassing most rough volatility models used in mathematical finance. In Chapter 2, we provide a unified treatment of pathwise large and moderate deviations principles for a general class of multidimensional stochastic Volterra equations with singular kernels, not necessarily of convolution form. Our methodology is based on the weak convergence approach by Budhiraja, Dupuis and Ellis.
This powerful approach also enables us to investigate the pathwise large deviations of families of white noise functionals characterised by their Wiener chaos expansion as~
In Chapter 3, we provide sufficient conditions for the large deviations principle to hold in path space, thereby refreshing a problem left open By PĂ©rez-Abreu (1993). Hinging on analysis on Wiener space, the proof involves describing, controlling and identifying the limit of perturbed multiple stochastic integrals.
In Chapter 4, we come back to mathematical finance via the route of Malliavin calculus. We present explicit small-time formulae for the at-the-money implied volatility, skew and curvature in a large class of models, including rough volatility models and their multi-factor versions. Our general setup encompasses both European options on a stock and VIX options. In particular, we develop a detailed analysis of the two-factor rough Bergomi model.
Finally, in Chapter 5, we consider the large-time behaviour of affine stochastic Volterra equations, an under-developed area in the absence of Markovianity.
We leverage on a measure-valued Markovian lift introduced by Cuchiero and Teichmann and the associated notion of generalised Feller property.
This setting allows us to prove the existence of an invariant measure for the lift and hence of a stationary distribution for the affine Volterra process, featuring in the rough Heston model.Open Acces
Mapping Super-Relaxed States of Myosin Heads in Sarcomeres using Oblique Angle Fluorescent Microscopy
We have utilised modern methods of super-resolution fluorescent microscopy to spatially map fluorescently labelled ATP molecules in relaxed rabbit psoas skeletal muscles. For our imaging process, we have labelled ATP molecules with Rhodamine and Z-lines with Alexa488. Data from imaging these fluorophores have been collected using oblique angle fluorescent microscopy and further analysed to map super relaxed states (SRX) of myosin heads on the thick filament. Our experiments have concluded that most SRX of myosin heads were found in the C-zone of the thick filament, while other zones of thick filament had smaller populations of SRX. Further introduction of mavacamten (MAVA) to our imaging system has revealed an increase in SRX in both D and P zones, while the C zone population of SRX had remained constant. Further experiments must be conducted to establish a clear pattern and further proof our findings
Investigating the mechanism of human beta defensin-2-mediated protection of skin barrier in vitro
The human skin barrier is a biological imperative. Chronic inflammatory skin diseases, such as Atopic Dermatitis (AD), are characterised by a reduction in skin barrier function and an increased number of secondary infections. Staphyloccocus aureus (S. aureus) has an increased presence on AD lesional skin and contributes significantly to AD pathology. It was previously demonstrated that the damage induced by a virulence factor of S. aureus, V8 protease, which causes further breakdown in skin barrier function, can be reduced by induction of human ÎČ- defensin (HBD)2 (by IL-1ÎČ) or exogenous HBD2 application. Induction of this defensin is impaired in AD skin. This thesis examines the mechanism of HBD2-mediated barrier protection in vitro; demonstrating that in this system, HBD2 was not providing protection through direct protease inhibition, nor was it altering keratinocyte proliferation or migration, or exhibiting specific localisation within the monolayer. Proteomics data demonstrated that HBD2 did not induce expression of known antiproteases but suggested that HBD2 stimulation may function by modulating expression of extracellular matrix proteins, specifically collagen- IVα2 and Laminin-ÎČ-1. Alternative pathways of protection initiated by IL-1ÎČ and TNFα stimulation were also investigated, as well as their influence over generalised wound healing. Finally, novel 3D human skin epidermal models were used to better recapitulate the structure of human epidermis and examine alterations to skin barrier function in a more physiological system. These data validate the barrier-protective properties of HBD2 and extended our knowledge of the consequences of exposure to this peptide in this context
Walking with the Earth: Intercultural Perspectives on Ethics of Ecological Caring
It is commonly believed that considering nature different from us, human beings (qua rational, cultural, religious and social actors), is detrimental to our engagement for the preservation of nature. An obvious example is animal rights, a deep concern for all living beings, including non-human living creatures, which is understandable only if we approach nature, without fearing it, as something which should remain outside of our true home. âWalking with the earthâ aims at questioning any similar preconceptions in the wide sense, including allegoric-poetic contributions. We invited 14 authors from 4 continents to express all sorts of ways of saying why caring is so important, why togetherness, being-with each others, as a spiritual but also embodied ethics is important in a divided world
How to Be a God
When it comes to questions concerning the nature of Reality, Philosophers and Theologians have the answers.
Philosophers have the answers that canât be proven right. Theologians have the answers that canât be proven wrong.
Todayâs designers of Massively-Multiplayer Online Role-Playing Games create realities for a living. They canât spend centuries mulling over the issues: they have to face them head-on. Their practical experiences can indicate which theoretical proposals actually work in practice.
Thatâs todayâs designers. Tomorrowâs will have a whole new set of questions to answer.
The designers of virtual worlds are the literal gods of those realities. Suppose Artificial Intelligence comes through and allows us to create non-player characters as smart as us. What are our responsibilities as gods? How should we, as gods, conduct ourselves?
How should we be gods
SYSTEMS METHODS FOR ANALYSIS OF HETEROGENEOUS GLIOBLASTOMA DATASETS TOWARDS ELUCIDATION OF INTER-TUMOURAL RESISTANCE PATHWAYS AND NEW THERAPEUTIC TARGETS
In this PhD thesis is described an endeavour to compile litterature about Glioblastoma key molecular mechanisms into a directed network followin Disease Maps standards, analyse its topology and compare results with quantitative analysis of multi-omics datasets in order to investigate Glioblastoma resistance mechanisms. The work also integrated implementation of Data Management good practices and procedures
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