Roll function in a flight simulator

Method introduces roll into the flying-spot scanner by modifying the scanning waveforms

A study of the means of increasing the dynamic range of visual simulation by means of a flying-spot scanner Final report

Increasing dynamic range of visual simulation for pilots using flying spot scanne

Moduli spaces of noncommutative instantons: gauging away noncommutative parameters

Using the theory of noncommutative geometry in a braided monoidal category, we improve upon a previous construction of noncommutative families of instantons of arbitrary charge on the deformed sphere S^4_\theta. We formulate a notion of noncommutative parameter spaces for families of instantons and we explore what it means for such families to be gauge equivalent, as well as showing how to remove gauge parameters using a noncommutative quotient construction. Although the parameter spaces are a priori noncommutative, we show that one may always recover a classical parameter space by making an appropriate choice of gauge transformation.Comment: v2: 44 pages; minor changes. To appear in Quart. J. Mat

Financial Engineering and Rationality: Experimental Evidence Based on the Monty Hall Problem

Financial engineering often involves redefining existing financial assets to create new financial products. This paper investigates whether financial engineering can alter the environment so that irrational agents can quickly learn to be rational. The specific environment we investigate is based on the Monty Hall problem, a well-studied choice anomaly. Our results show that, by the end of the experiment, the majority of subjects understand the Monty Hall anomaly. Average valuation of the experimental asset is very close to the expected value based on the true probabilities.experiment, behavioral finance

Parkinson's disease dementia: a neural networks perspective.

In the long-term, with progression of the illness, Parkinson's disease dementia affects up to 90% of patients with Parkinson's disease. With increasing life expectancy in western countries, Parkinson's disease dementia is set to become even more prevalent in the future. However, current treatments only give modest symptomatic benefit at best. New treatments are slow in development because unlike the pathological processes underlying the motor deficits of Parkinson's disease, the neural mechanisms underlying the dementing process and its associated cognitive deficits are still poorly understood. Recent insights from neuroscience research have begun to unravel the heterogeneous involvement of several distinct neural networks underlying the cognitive deficits in Parkinson's disease dementia, and their modulation by both dopaminergic and non-dopaminergic transmitter systems in the brain. In this review we collate emerging evidence regarding these distinct brain networks to give a novel perspective on the pathological mechanisms underlying Parkinson's disease dementia, and discuss how this may offer new therapeutic opportunities

The Gysin Sequence for Quantum Lens Spaces

We define quantum lens spaces as `direct sums of line bundles' and exhibit them as `total spaces' of certain principal bundles over quantum projective spaces. For each of these quantum lens spaces we construct an analogue of the classical Gysin sequence in K-theory. We use the sequence to compute the K-theory of the quantum lens spaces, in particular to give explicit geometric representatives of their K-theory classes. These representatives are interpreted as `line bundles' over quantum lens spaces and generically define `torsion classes'. We work out explicit examples of these classes.Comment: 27 pages. v2: No changes in the scientific content and results. Section 5 completely re-written and a final section added; suppressed two appendices; added references; minor changes throughout the paper. To appear in the JNc

S100B is increased in Parkinson’s disease and ablation protects against MPTP-induced toxicity through the RAGE and TNF-α pathway

Peer reviewedPublisher PD

Cytological Findings of 140 Bile Samples from Dogs and Cats and Associated Clinical Pathological Data

BACKGROUND: Cholecystocentesis can be part of the diagnostic workup of hepatobiliary disease in small animals, but literature on cytological evaluation of bile is scant. OBJECTIVES: To determine the diagnostic utility of cytological assessment of bile aspirates. ANIMALS: Fifty‐six and 78 client‐owned dogs and cats, respectively, with bile collected by cholecystocentesis and submitted to our diagnostic laboratory between 1999 and 2014. METHODS: Retrospective study describing cytological findings of bile, concurrent bacterial culture results, hematological and serum biochemical data, gallbladder biopsy results, as well as final diagnosis and complications after cholecystocentesis. RESULTS: Infectious agents were found in 30% of canine and 22% of feline bile aspirates, and inflammation in 5% and 19% respectively. Presence of microorganisms was more often detected on cytological examination (24%) than by culture (21%). The most common bacterial isolates were Escherichia coli and Enterococcus spp., isolated from 14.8% and 6.7% of cultured samples respectively. Only increased canine pancreatic lipase immunoreactivity concentration (cPLI) was significantly associated with the presence of microorganisms, inflammatory cells, or both in bile. Clinically relevant complications of cholecystocentesis occurred in 2 dogs. The majority of the animals undergoing cholecystocentesis suffered from hepatic, pancreatic, gastrointestinal disease, or a combination thereof. CONCLUSIONS AND CLINICAL IMPORTANCE: Cytological examination of bile is inexpensive and straightforward, and yields diagnostically relevant information that precedes and complements bacterial culture

Approaching stimuli bias attention in numerical space

Increasing evidence suggests that common mechanisms underlie the direction of attention in physical space and numerical space, along the mental number line. The small leftward bias (pseudoneglect) found on paper-and-pencil line bisection is also observed when participants ‘bisect’ number pairs, estimating (without calculating) the number midway between two others. Here we investigated the effect of stimulus motion on attention in numerical space. A two-frame apparent motion paradigm manipulating stimulus size was used to produce the impression that pairs of numbers were approaching (size increase from first to second frame), receding (size decrease), or not moving (no size change). The magnitude of pseudoneglect increased for approaching numbers, even when the final stimulus size was held constant. This result is consistent with previous findings that pseudoneglect in numerical space (as in physical space) increases as stimuli are brought closer to the participant. It also suggests that the perception of stimulus motion modulates attention over the mental number line and provides further support for a connection between the neural representations of physical space and number

Epileptic high-frequency network activity in a model of non-lesional temporal lobe epilepsy

High-frequency cortical activity, particularly in the 250–600 Hz (fast ripple) band, has been implicated in playing a crucial role in epileptogenesis and seizure generation. Fast ripples are highly specific for the seizure initiation zone. However, evidence for the association of fast ripples with epileptic foci depends on animal models and human cases with substantial lesions in the form of hippocampal sclerosis, which suggests that neuronal loss may be required for fast ripples. In the present work, we tested whether cell loss is a necessary prerequisite for the generation of fast ripples, using a non-lesional model of temporal lobe epilepsy that lacks hippocampal sclerosis. The model is induced by unilateral intrahippocampal injection of tetanus toxin. Recordings from the hippocampi of freely-moving epileptic rats revealed high-frequency activity (4100 Hz), including fast ripples. High-frequency activity was present both during interictal discharges and seizure onset. Interictal fast ripples proved a significantly more reliable marker of the primary epileptogenic zone than the presence of either interictal discharges or ripples (100–250 Hz). These results suggest that fast ripple activity should be considered for its potential value in the pre-surgical workup of non-lesional temporal lobe epilepsy