Symbol Synchronization for Diffusive Molecular Communication Systems

Symbol synchronization refers to the estimation of the start of a symbol interval and is needed for reliable detection. In this paper, we develop a symbol synchronization framework for molecular communication (MC) systems where we consider some practical challenges which have not been addressed in the literature yet. In particular, we take into account that in MC systems, the transmitter may not be equipped with an internal clock and may not be able to emit molecules with a fixed release frequency. Such restrictions hold for practical nanotransmitters, e.g. modified cells, where the lengths of the symbol intervals may vary due to the inherent randomness in the availability of food and energy for molecule generation, the process for molecule production, and the release process. To address this issue, we propose to employ two types of molecules, one for synchronization and one for data transmission. We derive the optimal maximum likelihood (ML) symbol synchronization scheme as a performance upper bound. Since ML synchronization entails high complexity, we also propose two low-complexity synchronization schemes, namely a peak observation-based scheme and a threshold-trigger scheme, which are suitable for MC systems with limited computational capabilities. Our simulation results reveal the effectiveness of the proposed synchronization~schemes and suggest that the end-to-end performance of MC systems significantly depends on the accuracy of symbol synchronization.Comment: This paper has been accepted for presentation at IEEE International Conference on Communications (ICC) 201

Bounds on Distance Estimation via Diffusive Molecular Communication

This paper studies distance estimation for diffusive molecular communication. The Cramer-Rao lower bound on the variance of the distance estimation error is derived. The lower bound is derived for a physically unbounded environment with molecule degradation and steady uniform flow. The maximum likelihood distance estimator is derived and its accuracy is shown via simulation to perform very close to the Cramer-Rao lower bound. An existing protocol is shown to be equivalent to the maximum likelihood distance estimator if only one observation is made. Simulation results also show the accuracy of existing protocols with respect to the Cramer-Rao lower bound.Comment: 7 pages, 5 figures, 1 table. Will be presented at the 2014 IEEE Global Communications Conference (GLOBECOM) in Austin, TX, USA, on December 9, 201

One symbol blind synchronization in SIMO molecular communication systems

Molecular communication offers new possibilities in the micro-and nano-scale application environments. Similar to other communication paradigms, molecular communication also requires clock synchronization between the transmitter and the receiver nanomachine in many time-and control-sensitive applications. This letter presents a novel high-efficiency blind clock synchronization mechanism. Without knowing the channel parameters of the diffusion coefficient and the transmitter-receiver distance, the receiver only requires one symbol to achieve synchronization. The samples are used to estimate the propagation delay by least square method and achieve clock synchronization. Single-input multiple-output (SIMO) diversity design is then proposed to mitigate channel noise and therefore to improve the synchronization accuracy. The simulation results show that the proposed clock synchronization mechanism has a good performance and may help chronopharmaceutical drug delivery applications