Biomimetic Design and Fabrication of Interior Architecture of Tissue Scaffolds Using Solid Freeform Fabrication

Modeling, design and fabrication of tissue scaffolds with intricate architecture, porosity and pore size for desired tissue properties presents a challenge in tissue engineering. This paper will present the details of our development in designing and fabrication of the interior architecture of scaffolds using a novel design approach. The Interior Architecture Design (IAD) approach seeks to generate scaffold layered freeform fabrication tool path without forming complicated 3D CAD scaffold models. This involves: applying the principle of layered manufacturing to determine the scaffold individual layered process planes and layered contour; defining the 2D characteristic patterns of the scaffold building blocks (unit cells) to form the Interior Scaffold Pattern; and the generation of process tool path for freeform fabrication of these scaffolds with the specified interior architecture. Feasibility studies applying the IAD algorithm to example models and the generation of fabrication planning instructions will be presented.Mechanical Engineerin

Quantum autoencoders via quantum adders with genetic algorithms

The quantum autoencoder is a recent paradigm in the field of quantum machine learning, which may enable an enhanced use of resources in quantum technologies. To this end, quantum neural networks with less nodes in the inner than in the outer layers were considered. Here, we propose a useful connection between approximate quantum adders and quantum autoencoders. Specifically, this link allows us to employ optimized approximate quantum adders, obtained with genetic algorithms, for the implementation of quantum autoencoders for a variety of initial states. Furthermore, we can also directly optimize the quantum autoencoders via genetic algorithms. Our approach opens a different path for the design of quantum autoencoders in controllable quantum platforms

Biological control networks suggest the use of biomimetic sets for combinatorial therapies

Cells are regulated by networks of controllers having many targets, and targets affected by many controllers, but these "many-to-many" combinatorial control systems are poorly understood. Here we analyze distinct cellular networks (transcription factors, microRNAs, and protein kinases) and a drug-target network. Certain network properties seem universal across systems and species, suggesting the existence of common control strategies in biology. The number of controllers is ~8% of targets and the density of links is 2.5% \pm 1.2%. Links per node are predominantly exponentially distributed, implying conservation of the average, which we explain using a mathematical model of robustness in control networks. These findings suggest that optimal pharmacological strategies may benefit from a similar, many-to-many combinatorial structure, and molecular tools are available to test this approach.Comment: 33 page

Cosmotic, Aquatic. Exploring the potential of computational design in the preservation of aquatic ecotones

This paper looks at the possible role of computational design ecologically in the fight against the loss of the aquatic Ecotone. As climate change keeps altering all the natural aspects of our planet, and as our kind continues to sabotage its ecologies, coral reefs come in focus. Aquatically, coral reefs count as a fertile zone for biodiversity. Usually being the Ecotone between land and sea, these barriers host many species and riches. However, due to the excessive abuse caused by human activity be it world-wide pollution or direct human contact, these reefs are constantly bleaching and breaking. In 2016, the Architecture Association gathered a group of international architecture students and professionals in a visiting school in Jordan titled “Hyperbolic Reefs” looking at the possibility of recruiting new computational methods to preserve and possibly regenerate the Ecotone. It was considered that new simulation techniques along with parametric design could contribute into the assessment and prevention of the catastrophic results. The two-week event was divided into chapters and was initiated by a series of lectures and discussions conducted by worldwide leading architects and experts who presented an important material to build upon. Then, the participants underwent a site visit to the coral reef of Al-Aqaba, collecting data, samples and media and recording insights and local testimonies. The third step of the experience was to assimilate the material and data and discuss openly the ways that computation could lead to a better coral life. Several software and tools were assigned to produce a design that would help attenuate the compromise of the coral reef through computation. An archive of data was produced and exhibited to the public. The results of this brief exercise was a number of suggestions and future aspirations triggered solely towards revitalizing the Ecotone. Issues such as the abundance of irresponsible snorkeling and diving, many governments’ indifferent policies towards the coral reefs, global warming, climate change, coral bleaching and aquatic architecture were confronted through parametric projects ranging from purely architectural to abstract human capsules. Computational tools allowed the reproduction of the whole system digitally, the precise tracing of the corals’ patterns, dimensions and colors, simulation software predicted the role of light and heat in certain zones, and parametric programs provided an incomparable flexibility in the designing process, going completely in sync with the fragile and intricate aspect of a coral unit. 3D printing was also an integral factor in the presentation and study of the presented models. This study’s scope was to expand the use of computation in a theoretical way to reach new and creative prospects, and to raise awareness to the situation of the coral reef and the risks facing its degradation