23,155 research outputs found
Mechanochemical models for generating biological pattern and form in development
The central issue in development is the formation of spatial patterns of cells in the early embryo. The mechanisms which generate these patterns are unknown. Here we describe the new Oster-Murray mechanochemical approach to the problem, the elements of which are experimentally well documented. By way of illustration we derive one of the basic models from first principles and apply it to a variety of problems of current interest and research. We specifically discuss the formation of skin organ patterns, such as feather and scale germs, cartilage condensations in the developing vertebrate limb and finally wound healing
A design principle for vascular beds: the effects of complex blood rheology
We propose a design principle that extends Murray's original optimization principle for vascular architecture to account for complex blood rheology. Minimization of an energy dissipation function enables us to determine how rheology affects the morphology of simple branching networks. The behavior of various physical quantities associated with the networks, such as the wall shear stress and the flow velocity, is also determined. Our results are shown to be qualitatively and quantitatively compatible with independent experimental observations and simulations
Cutting edge: back to "one-way" germinal centers
The present status of germinal center (GC) research is revisited using in silico simulations based on recent lymphocyte motility data in mice. The generally adopted view of several rounds of somatic hypermutations and positive selection is analyzed with special emphasis on the spatial organization of the GC reaction. We claim that the development of dark zones is not necessary for successful GC reactions to develop. We find that a recirculation of positively selected centrocytes to the dark zone is rather unlikely. Instead we propose a scenario that combines a multiple-step mutation and selection concept with a "one-way" GC in the sense of cell migration
Fundamentals and applications of spatial dissipative solitons in photonic devices : [Chapter 6]
We review the properties of optical spatial dissipative solitons (SDS). These are stable, self‐localized optical excitations sitting on a uniform, or quasi‐uniform, background in a dissipative environment like a nonlinear optical cavity. Indeed, in optics they are often termed “cavity solitons.” We discuss their dynamics and interactions in both ideal and imperfect systems, making comparison with experiments. SDS in lasers offer important advantages for applications. We review candidate schemes and the tremendous recent progress in semiconductor‐based cavity soliton lasers. We examine SDS in periodic structures, and we show how SDS can be quantitatively related to the locking of fronts. We conclude with an assessment of potential applications of SDS in photonics, arguing that best use of their particular features is made by exploiting their mobility, for example in all‐optical delay lines
Towards dynamical network biomarkers in neuromodulation of episodic migraine
Computational methods have complemented experimental and clinical
neursciences and led to improvements in our understanding of the nervous
systems in health and disease. In parallel, neuromodulation in form of electric
and magnetic stimulation is gaining increasing acceptance in chronic and
intractable diseases. In this paper, we firstly explore the relevant state of
the art in fusion of both developments towards translational computational
neuroscience. Then, we propose a strategy to employ the new theoretical concept
of dynamical network biomarkers (DNB) in episodic manifestations of chronic
disorders. In particular, as a first example, we introduce the use of
computational models in migraine and illustrate on the basis of this example
the potential of DNB as early-warning signals for neuromodulation in episodic
migraine.Comment: 13 pages, 5 figure
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