A conceptual treadmill: the need for ‘middle ground’ in clinical decision making theory in nursing

This paper explores the two predominant theoretical approaches to the process of nurse decision making prevalent within the nursing research literature: systematic-positivistic approaches as exemplifed by information processing theory, and the intuitive-humanistic approach of Patricia Benner. The two approaches' strengths and weaknesses are explored and as a result a third theoretical stance is proffered: the idea of a cognitive continuum. According to this approach the systematic and intuitive theoretical camps occupy polar positions at either end of a continuum as opposed to separate theoretical planes. The methodological and professional benefits of adopting such a stance are also briefly outlined

Towards an alternative to Benner’s theory of expert intuition in nursing: A discussion paper

Several authors have highlighted the role of intuition in expertise. In particular, a large amount of data has been collected about intuition in expert nursing, and intuition plays an important role in the influential theory of nursing expertise developed by Benner (1984). We discuss this theory, and highlight both data that support it and data that challenge it. Based on this assessment, we propose a new theory of nursing expertise and intuition, which emphasizes how perception and conscious problem solving are intimately related. In the discussion, we propose that this theory opens new avenues of enquiry for research into nursing expertise

ModHMM: A Modular Supra-Bayesian Genome Segmentation Method

Genome segmentation methods are powerful tools to obtain cell type or tissue-specific genome-wide annotations and are frequently used to discover regulatory elements. However, traditional segmentation methods show low predictive accuracy and their data-driven annotations have some undesirable properties. As an alternative, we developed ModHMM, a highly modular genome segmentation method. Inspired by the supra-Bayesian approach, it incorporates predictions from a set of classifiers. This allows to compute genome segmentations by utilizing state-of-the-art methodology. We demonstrate the method on ENCODE data and show that it outperforms traditional segmentation methods not only in terms of predictive performance, but also in qualitative aspects. Therefore, ModHMM is a valuable alternative to study the epigenetic and regulatory landscape across and within cell types or tissues

Peer Methods for the Solution of Large-Scale Differential Matrix Equations

We consider the application of implicit and linearly implicit (Rosenbrock-type) peer methods to matrix-valued ordinary differential equations. In particular the differential Riccati equation (DRE) is investigated. For the Rosenbrock-type schemes, a reformulation capable of avoiding a number of Jacobian applications is developed that, in the autonomous case, reduces the computational complexity of the algorithms. Dealing with large-scale problems, an efficient implementation based on low-rank symmetric indefinite factorizations is presented. The performance of both peer approaches up to order 4 is compared to existing implicit time integration schemes for matrix-valued differential equations.Comment: 29 pages, 2 figures (including 6 subfigures each), 3 tables, Corrected typo

On Error Estimation for Reduced-order Modeling of Linear Non-parametric and Parametric Systems

Motivated by a recently proposed error estimator for the transfer function of the reduced-order model of a given linear dynamical system, we further develop more theoretical results in this work. Furthermore, we propose several variants of the error estimator, and compare those variants with the existing ones both theoretically and numerically. It has been shown that some of the proposed error estimators perform better than or equally well as the existing ones. All the error estimators considered can be easily extended to estimate output error of reduced-order modeling for steady linear parametric systems.Comment: 34 pages, 12 figure