Computerized Analysis of Magnetic Resonance Images to Study Cerebral Anatomy in Developing Neonates

The study of cerebral anatomy in developing neonates is of great importance for the understanding of brain development during the early period of life. This dissertation therefore focuses on three challenges in the modelling of cerebral anatomy in neonates during brain development. The methods that have been developed all use Magnetic Resonance Images (MRI) as source data. To facilitate study of vascular development in the neonatal period, a set of image analysis algorithms are developed to automatically extract and model cerebral vessel trees. The whole process consists of cerebral vessel tracking from automatically placed seed points, vessel tree generation, and vasculature registration and matching. These algorithms have been tested on clinical Time-of- Flight (TOF) MR angiographic datasets. To facilitate study of the neonatal cortex a complete cerebral cortex segmentation and reconstruction pipeline has been developed. Segmentation of the neonatal cortex is not effectively done by existing algorithms designed for the adult brain because the contrast between grey and white matter is reversed. This causes pixels containing tissue mixtures to be incorrectly labelled by conventional methods. The neonatal cortical segmentation method that has been developed is based on a novel expectation-maximization (EM) method with explicit correction for mislabelled partial volume voxels. Based on the resulting cortical segmentation, an implicit surface evolution technique is adopted for the reconstruction of the cortex in neonates. The performance of the method is investigated by performing a detailed landmark study. To facilitate study of cortical development, a cortical surface registration algorithm for aligning the cortical surface is developed. The method first inflates extracted cortical surfaces and then performs a non-rigid surface registration using free-form deformations (FFDs) to remove residual alignment. Validation experiments using data labelled by an expert observer demonstrate that the method can capture local changes and follow the growth of specific sulcus

Modeling, Simulation and Emulation of Intelligent Domotic Environments

Intelligent Domotic Environments are a promising approach, based on semantic models and commercially off-the-shelf domotic technologies, to realize new intelligent buildings, but such complexity requires innovative design methodologies and tools for ensuring correctness. Suitable simulation and emulation approaches and tools must be adopted to allow designers to experiment with their ideas and to incrementally verify designed policies in a scenario where the environment is partly emulated and partly composed of real devices. This paper describes a framework, which exploits UML2.0 state diagrams for automatic generation of device simulators from ontology-based descriptions of domotic environments. The DogSim simulator may simulate a complete building automation system in software, or may be integrated in the Dog Gateway, allowing partial simulation of virtual devices alongside with real devices. Experiments on a real home show that the approach is feasible and can easily address both simulation and emulation requirement

Integration of LIDAR and IFSAR for mapping

LiDAR and IfSAR data is now widely used for a number of applications, particularly those needing a digital elevation model. The data is often complementary to other data such as aerial imagery and high resolution satellite data. This paper will review the current data sources and the products and then look at the ways in which the data can be integrated for particular applications. The main platforms for LiDAR are either helicopter or fixed wing aircraft, often operating at low altitudes, a digital camera is frequently included on the platform, there is an interest in using other sensors such as 3 line cameras of hyperspectral scanners. IfSAR is used from satellite platforms, or from aircraft, the latter are more compatible with LiDAR for integration. The paper will examine the advantages and disadvantages of LiDAR and IfSAR for DEM generation and discuss the issues which still need to be dealt with. Examples of applications will be given and particularly those involving the integration of different types of data. Examples will be given from various sources and future trends examined

A Neural Model for Generating Natural Language Summaries of Program Subroutines

Source code summarization -- creating natural language descriptions of source code behavior -- is a rapidly-growing research topic with applications to automatic documentation generation, program comprehension, and software maintenance. Traditional techniques relied on heuristics and templates built manually by human experts. Recently, data-driven approaches based on neural machine translation have largely overtaken template-based systems. But nearly all of these techniques rely almost entirely on programs having good internal documentation; without clear identifier names, the models fail to create good summaries. In this paper, we present a neural model that combines words from code with code structure from an AST. Unlike previous approaches, our model processes each data source as a separate input, which allows the model to learn code structure independent of the text in code. This process helps our approach provide coherent summaries in many cases even when zero internal documentation is provided. We evaluate our technique with a dataset we created from 2.1m Java methods. We find improvement over two baseline techniques from SE literature and one from NLP literature