Automating Carotid Intima-Media Thickness Video Interpretation with Convolutional Neural Networks

Cardiovascular disease (CVD) is the leading cause of mortality yet largely preventable, but the key to prevention is to identify at-risk individuals before adverse events. For predicting individual CVD risk, carotid intima-media thickness (CIMT), a noninvasive ultrasound method, has proven to be valuable, offering several advantages over CT coronary artery calcium score. However, each CIMT examination includes several ultrasound videos, and interpreting each of these CIMT videos involves three operations: (1) select three end-diastolic ultrasound frames (EUF) in the video, (2) localize a region of interest (ROI) in each selected frame, and (3) trace the lumen-intima interface and the media-adventitia interface in each ROI to measure CIMT. These operations are tedious, laborious, and time consuming, a serious limitation that hinders the widespread utilization of CIMT in clinical practice. To overcome this limitation, this paper presents a new system to automate CIMT video interpretation. Our extensive experiments demonstrate that the suggested system significantly outperforms the state-of-the-art methods. The superior performance is attributable to our unified framework based on convolutional neural networks (CNNs) coupled with our informative image representation and effective post-processing of the CNN outputs, which are uniquely designed for each of the above three operations.Comment: J. Y. Shin, N. Tajbakhsh, R. T. Hurst, C. B. Kendall, and J. Liang. Automating carotid intima-media thickness video interpretation with convolutional neural networks. CVPR 2016, pp 2526-2535; N. Tajbakhsh, J. Y. Shin, R. T. Hurst, C. B. Kendall, and J. Liang. Automatic interpretation of CIMT videos using convolutional neural networks. Deep Learning for Medical Image Analysis, Academic Press, 201

Deep Learning in Cardiology

The medical field is creating large amount of data that physicians are unable to decipher and use efficiently. Moreover, rule-based expert systems are inefficient in solving complicated medical tasks or for creating insights using big data. Deep learning has emerged as a more accurate and effective technology in a wide range of medical problems such as diagnosis, prediction and intervention. Deep learning is a representation learning method that consists of layers that transform the data non-linearly, thus, revealing hierarchical relationships and structures. In this review we survey deep learning application papers that use structured data, signal and imaging modalities from cardiology. We discuss the advantages and limitations of applying deep learning in cardiology that also apply in medicine in general, while proposing certain directions as the most viable for clinical use.Comment: 27 pages, 2 figures, 10 table

Sparsely Activated Networks: A new method for decomposing and compressing data

Recent literature on unsupervised learning focused on designing structural priors with the aim of learning meaningful features, but without considering the description length of the representations. In this thesis, first we introduce the{\phi}metric that evaluates unsupervised models based on their reconstruction accuracy and the degree of compression of their internal representations. We then present and define two activation functions (Identity, ReLU) as base of reference and three sparse activation functions (top-k absolutes, Extrema-Pool indices, Extrema) as candidate structures that minimize the previously defined metric $\varphi$. We lastly present Sparsely Activated Networks (SANs) that consist of kernels with shared weights that, during encoding, are convolved with the input and then passed through a sparse activation function. During decoding, the same weights are convolved with the sparse activation map and subsequently the partial reconstructions from each weight are summed to reconstruct the input. We compare SANs using the five previously defined activation functions on a variety of datasets (Physionet, UCI-epilepsy, MNIST, FMNIST) and show that models that are selected using $\varphi$ have small description representation length and consist of interpretable kernels.Comment: PhD Thesis in Greek, 158 pages for the main text, 23 supplementary pages for presentation, arXiv:1907.06592, arXiv:1904.13216, arXiv:1902.1112