1,893 research outputs found
DFDL: Discriminative Feature-oriented Dictionary Learning for Histopathological Image Classification
In histopathological image analysis, feature extraction for classification is
a challenging task due to the diversity of histology features suitable for each
problem as well as presence of rich geometrical structure. In this paper, we
propose an automatic feature discovery framework for extracting discriminative
class-specific features and present a low-complexity method for classification
and disease grading in histopathology. Essentially, our Discriminative
Feature-oriented Dictionary Learning (DFDL) method learns class-specific
features which are suitable for representing samples from the same class while
are poorly capable of representing samples from other classes. Experiments on
three challenging real-world image databases: 1) histopathological images of
intraductal breast lesions, 2) mammalian lung images provided by the Animal
Diagnostics Lab (ADL) at Pennsylvania State University, and 3) brain tumor
images from The Cancer Genome Atlas (TCGA) database, show the significance of
DFDL model in a variety problems over state-of-the-art methodsComment: Accepted to IEEE International Symposium on Biomedical Imaging
(ISBI), 201
Patch-based Convolutional Neural Network for Whole Slide Tissue Image Classification
Convolutional Neural Networks (CNN) are state-of-the-art models for many
image classification tasks. However, to recognize cancer subtypes
automatically, training a CNN on gigapixel resolution Whole Slide Tissue Images
(WSI) is currently computationally impossible. The differentiation of cancer
subtypes is based on cellular-level visual features observed on image patch
scale. Therefore, we argue that in this situation, training a patch-level
classifier on image patches will perform better than or similar to an
image-level classifier. The challenge becomes how to intelligently combine
patch-level classification results and model the fact that not all patches will
be discriminative. We propose to train a decision fusion model to aggregate
patch-level predictions given by patch-level CNNs, which to the best of our
knowledge has not been shown before. Furthermore, we formulate a novel
Expectation-Maximization (EM) based method that automatically locates
discriminative patches robustly by utilizing the spatial relationships of
patches. We apply our method to the classification of glioma and non-small-cell
lung carcinoma cases into subtypes. The classification accuracy of our method
is similar to the inter-observer agreement between pathologists. Although it is
impossible to train CNNs on WSIs, we experimentally demonstrate using a
comparable non-cancer dataset of smaller images that a patch-based CNN can
outperform an image-based CNN
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