29,383 research outputs found
Next challenges for adaptive learning systems
Learning from evolving streaming data has become a 'hot' research topic in the last decade and many adaptive learning algorithms have been developed. This research was stimulated by rapidly growing amounts of industrial, transactional, sensor and other business data that arrives in real time and needs to be mined in real time. Under such circumstances, constant manual adjustment of models is in-efficient and with increasing amounts of data is becoming infeasible. Nevertheless, adaptive learning models are still rarely employed in business applications in practice. In the light of rapidly growing structurally rich 'big data', new generation of parallel computing solutions and cloud computing services as well as recent advances in portable computing devices, this article aims to identify the current key research directions to be taken to bring the adaptive learning closer to application needs. We identify six forthcoming challenges in designing and building adaptive learning (pre-diction) systems: making adaptive systems scalable, dealing with realistic data, improving usability and trust, integrat-ing expert knowledge, taking into account various application needs, and moving from adaptive algorithms towards adaptive tools. Those challenges are critical for the evolving stream settings, as the process of model building needs to be fully automated and continuous.</jats:p
High-throughput Binding Affinity Calculations at Extreme Scales
Resistance to chemotherapy and molecularly targeted therapies is a major
factor in limiting the effectiveness of cancer treatment. In many cases,
resistance can be linked to genetic changes in target proteins, either
pre-existing or evolutionarily selected during treatment. Key to overcoming
this challenge is an understanding of the molecular determinants of drug
binding. Using multi-stage pipelines of molecular simulations we can gain
insights into the binding free energy and the residence time of a ligand, which
can inform both stratified and personal treatment regimes and drug development.
To support the scalable, adaptive and automated calculation of the binding free
energy on high-performance computing resources, we introduce the High-
throughput Binding Affinity Calculator (HTBAC). HTBAC uses a building block
approach in order to attain both workflow flexibility and performance. We
demonstrate close to perfect weak scaling to hundreds of concurrent multi-stage
binding affinity calculation pipelines. This permits a rapid time-to-solution
that is essentially invariant of the calculation protocol, size of candidate
ligands and number of ensemble simulations. As such, HTBAC advances the state
of the art of binding affinity calculations and protocols
Elastic Business Process Management: State of the Art and Open Challenges for BPM in the Cloud
With the advent of cloud computing, organizations are nowadays able to react
rapidly to changing demands for computational resources. Not only individual
applications can be hosted on virtual cloud infrastructures, but also complete
business processes. This allows the realization of so-called elastic processes,
i.e., processes which are carried out using elastic cloud resources. Despite
the manifold benefits of elastic processes, there is still a lack of solutions
supporting them.
In this paper, we identify the state of the art of elastic Business Process
Management with a focus on infrastructural challenges. We conceptualize an
architecture for an elastic Business Process Management System and discuss
existing work on scheduling, resource allocation, monitoring, decentralized
coordination, and state management for elastic processes. Furthermore, we
present two representative elastic Business Process Management Systems which
are intended to counter these challenges. Based on our findings, we identify
open issues and outline possible research directions for the realization of
elastic processes and elastic Business Process Management.Comment: Please cite as: S. Schulte, C. Janiesch, S. Venugopal, I. Weber, and
P. Hoenisch (2015). Elastic Business Process Management: State of the Art and
Open Challenges for BPM in the Cloud. Future Generation Computer Systems,
Volume NN, Number N, NN-NN., http://dx.doi.org/10.1016/j.future.2014.09.00
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