2 research outputs found
Cerebral blood flow in the pig : a study of Xenon-133 clearance techniques
Cerebrovascular disease is an important cause
of death. The number of cerebrovascular complaints is
increasing, mainly as a consequence of increasing the
mean lifetime. Functioning of the brain is dependent
on blood supply. A temporary or prolonged reduction of
total or regional cerebral blood flow (c.b.f.) may lead
to irreversible damage of cerebral tissue and loss of
neurological functions. Therefore the measurement of
cerebral blood flow, preferably in different regions,
is clinically important. Several methods of measuring
c.b.f. have been developed. The applicability of a
method in a clinical situation depends on its traumatic
aspects. A brief survey of the methods of c.b.f.
measurement is given at the end of this chapter. The
clinical method used most frequently is the Xe-133
clearance technique. The Xe-133 is administered by three
different routes, intra-arterial, intravenous or by
inhalation. This thesis mainly deals with the intraarterial
injection technique, evaluated on the pig as
experimental animal