Automatic Lesion Boundary Segmentation in Dermoscopic Images with Ensemble Deep Learning Methods

Early detection of skin cancer, particularly melanoma, is crucial to enable advanced treatment. Due to the rapid growth in the numbers of skin cancers, there is a growing need of computerized analysis for skin lesions. The state-of-the-art public available datasets for skin lesions are often accompanied with very limited amount of segmentation ground truth labeling as it is laborious and expensive. The lesion boundary segmentation is vital to locate the lesion accurately in dermoscopic images and lesion diagnosis of different skin lesion types. In this work, we propose the use of fully automated deep learning ensemble methods for accurate lesion boundary segmentation in dermoscopic images. We trained the Mask-RCNN and DeepLabv3+ methods on ISIC-2017 segmentation training set and evaluate the performance of the ensemble networks on ISIC-2017 testing set. Our results showed that the best proposed ensemble method segmented the skin lesions with Jaccard index of 79.58% for the ISIC-2017 testing set. The proposed ensemble method outperformed FrCN, FCN, U-Net, and SegNet in Jaccard Index by 2.48%, 7.42%, 17.95%, and 9.96% respectively. Furthermore, the proposed ensemble method achieved an accuracy of 95.6% for some representative clinically benign cases, 90.78% for the melanoma cases, and 91.29% for the seborrheic keratosis cases on ISIC-2017 testing set, exhibiting better performance than FrCN, FCN, U-Net, and SegNet.Comment: 7 pages, 8 figures and 4 tables. arXiv admin note: text overlap with arXiv:1711.1044

What evidence does deep learning model use to classify Skin Lesions?

Melanoma is a type of skin cancer with the most rapidly increasing incidence. Early detection of melanoma using dermoscopy images significantly increases patients' survival rate. However, accurately classifying skin lesions by eye, especially in the early stage of melanoma, is extremely challenging for the dermatologists. Hence, the discovery of reliable biomarkers will be meaningful for melanoma diagnosis. Recent years, the value of deep learning empowered computer-assisted diagnose has been shown in biomedical imaging based decision making. However, much research focuses on improving disease detection accuracy but not exploring the evidence of pathology. In this paper, we propose a method to interpret the deep learning classification findings. Firstly, we propose an accurate neural network architecture to classify skin lesions. Secondly, we utilize a prediction difference analysis method that examines each patch on the image through patch-wised corrupting to detect the biomarkers. Lastly, we validate that our biomarker findings are corresponding to the patterns in the literature. The findings can be significant and useful to guide clinical diagnosis.Comment: 5 page

Automatic Skin Lesion Analysis using Large-scale Dermoscopy Images and Deep Residual Networks

Malignant melanoma has one of the most rapidly increasing incidences in the world and has a considerable mortality rate. Early diagnosis is particularly important since melanoma can be cured with prompt excision. Dermoscopy images play an important role in the non-invasive early detection of melanoma [1]. However, melanoma detection using human vision alone can be subjective, inaccurate and poorly reproducible even among experienced dermatologists. This is attributed to the challenges in interpreting images with diverse characteristics including lesions of varying sizes and shapes, lesions that may have fuzzy boundaries, different skin colors and the presence of hair [2]. Therefore, the automatic analysis of dermoscopy images is a valuable aid for clinical decision making and for image-based diagnosis to identify diseases such as melanoma [1-4]. Deep residual networks (ResNets) has achieved state-of-the-art results in image classification and detection related problems [5-8]. In this ISIC 2017 skin lesion analysis challenge [9], we propose to exploit the deep ResNets for robust visual features learning and representations.Comment: Submission for ISIC2017 Challeng

Solo or Ensemble? Choosing a CNN Architecture for Melanoma Classification

Convolutional neural networks (CNNs) deliver exceptional results for computer vision, including medical image analysis. With the growing number of available architectures, picking one over another is far from obvious. Existing art suggests that, when performing transfer learning, the performance of CNN architectures on ImageNet correlates strongly with their performance on target tasks. We evaluate that claim for melanoma classification, over 9 CNNs architectures, in 5 sets of splits created on the ISIC Challenge 2017 dataset, and 3 repeated measures, resulting in 135 models. The correlations we found were, to begin with, much smaller than those reported by existing art, and disappeared altogether when we considered only the top-performing networks: uncontrolled nuisances (i.e., splits and randomness) overcome any of the analyzed factors. Whenever possible, the best approach for melanoma classification is still to create ensembles of multiple models. We compared two choices for selecting which models to ensemble: picking them at random (among a pool of high-quality ones) vs. using the validation set to determine which ones to pick first. For small ensembles, we found a slight advantage on the second approach but found that random choice was also competitive. Although our aim in this paper was not to maximize performance, we easily reached AUCs comparable to the first place on the ISIC Challenge 2017.Comment: ISIC Skin Image Analysis Workshop @ CVPR 201

Skin Lesion Classification Using Deep Multi-scale Convolutional Neural Networks

We present a deep learning approach to the ISIC 2017 Skin Lesion Classification Challenge using a multi-scale convolutional neural network. Our approach utilizes an Inception-v3 network pre-trained on the ImageNet dataset, which is fine-tuned for skin lesion classification using two different scales of input images

An Overview of Melanoma Detection in Dermoscopy Images Using Image Processing and Machine Learning

The incidence of malignant melanoma continues to increase worldwide. This cancer can strike at any age; it is one of the leading causes of loss of life in young persons. Since this cancer is visible on the skin, it is potentially detectable at a very early stage when it is curable. New developments have converged to make fully automatic early melanoma detection a real possibility. First, the advent of dermoscopy has enabled a dramatic boost in clinical diagnostic ability to the point that melanoma can be detected in the clinic at the very earliest stages. The global adoption of this technology has allowed accumulation of large collections of dermoscopy images of melanomas and benign lesions validated by histopathology. The development of advanced technologies in the areas of image processing and machine learning have given us the ability to allow distinction of malignant melanoma from the many benign mimics that require no biopsy. These new technologies should allow not only earlier detection of melanoma, but also reduction of the large number of needless and costly biopsy procedures. Although some of the new systems reported for these technologies have shown promise in preliminary trials, widespread implementation must await further technical progress in accuracy and reproducibility. In this paper, we provide an overview of computerized detection of melanoma in dermoscopy images. First, we discuss the various aspects of lesion segmentation. Then, we provide a brief overview of clinical feature segmentation. Finally, we discuss the classification stage where machine learning algorithms are applied to the attributes generated from the segmented features to predict the existence of melanoma.Comment: 15 pages, 3 figure

Segmentation of Skin Lesions and their Attributes Using Multi-Scale Convolutional Neural Networks and Domain Specific Augmentations

Computer-aided diagnosis systems for classification of different type of skin lesions have been an active field of research in recent decades. It has been shown that introducing lesions and their attributes masks into lesion classification pipeline can greatly improve the performance. In this paper, we propose a framework by incorporating transfer learning for segmenting lesions and their attributes based on the convolutional neural networks. The proposed framework is based on the encoder-decoder architecture which utilizes a variety of pre-trained networks in the encoding path and generates the prediction map by combining multi-scale information in decoding path using a pyramid pooling manner. To address the lack of training data and increase the proposed model generalization, an extensive set of novel domain-specific augmentation routines have been applied to simulate the real variations in dermoscopy images. Finally, by performing broad experiments on three different data sets obtained from International Skin Imaging Collaboration archive (ISIC2016, ISIC2017, and ISIC2018 challenges data sets), we show that the proposed method outperforms other state-of-the-art approaches for ISIC2016 and ISIC2017 segmentation task and achieved the first rank on the leader-board of ISIC2018 attribute detection task.Comment: 18 page

Dynamic recursive tree-based partitioning for malignant melanoma identification in skin lesion dermoscopic images

In this paper, multivalued data or multiple values variables are defined. They are typical when there is some intrinsic uncertainty in data production, as the result of imprecise measuring instruments, such as in image recognition, in human judgments and so on. \noindent So far, contributions in symbolic data analysis literature provide data preprocessing criteria allowing for the use of standard methods such as factorial analysis, clustering, discriminant analysis, tree-based methods. As an alternative, this paper introduces a methodology for supervised classification, the so-called Dynamic CLASSification TREE (D-CLASS TREE), dealing simultaneously with both standard and multivalued data as well. For that, an innovative partitioning criterion with a tree-growing algorithm will be defined. Main result is a dynamic tree structure characterized by the simultaneous presence of binary and ternary partitions. A real world case study will be considered to show the advantages of the proposed methodology and main issues of the interpretation of the final results. A comparative study with other approaches dealing with the same types of data will be also shown. D-CLASS TREE outperforms its competitors in terms of accuracy, which is a fundamental aspect for predictive learning

Lesion Border Detection in Dermoscopy Images Using Ensembles of Thresholding Methods

Dermoscopy is one of the major imaging modalities used in the diagnosis of melanoma and other pigmented skin lesions. Due to the difficulty and subjectivity of human interpretation, automated analysis of dermoscopy images has become an important research area. Border detection is often the first step in this analysis. In many cases, the lesion can be roughly separated from the background skin using a thresholding method applied to the blue channel. However, no single thresholding method appears to be robust enough to successfully handle the wide variety of dermoscopy images encountered in clinical practice. In this paper, we present an automated method for detecting lesion borders in dermoscopy images using ensembles of thresholding methods. Experiments on a difficult set of 90 images demonstrate that the proposed method is robust, fast, and accurate when compared to nine state-of-the-art methods.Comment: 8 pages, 3 figures, 2 tables. arXiv admin note: substantial text overlap with arXiv:1009.136

A Deep Multi-task Learning Approach to Skin Lesion Classification

Skin lesion identification is a key step toward dermatological diagnosis. When describing a skin lesion, it is very important to note its body site distribution as many skin diseases commonly affect particular parts of the body. To exploit the correlation between skin lesions and their body site distributions, in this study, we investigate the possibility of improving skin lesion classification using the additional context information provided by body location. Specifically, we build a deep multi-task learning (MTL) framework to jointly optimize skin lesion classification and body location classification (the latter is used as an inductive bias). Our MTL framework uses the state-of-the-art ImageNet pretrained model with specialized loss functions for the two related tasks. Our experiments show that the proposed MTL based method performs more robustly than its standalone (single-task) counterpart.Comment: AAAI 2017 Joint Workshop on Health Intelligence W3PHIAI 2017 (W3PHI & HIAI), San Francisco, CA, 201