1,090 research outputs found

    Multidisciplinary perspectives on Artificial Intelligence and the law

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    This open access book presents an interdisciplinary, multi-authored, edited collection of chapters on Artificial Intelligence (‘AI’) and the Law. AI technology has come to play a central role in the modern data economy. Through a combination of increased computing power, the growing availability of data and the advancement of algorithms, AI has now become an umbrella term for some of the most transformational technological breakthroughs of this age. The importance of AI stems from both the opportunities that it offers and the challenges that it entails. While AI applications hold the promise of economic growth and efficiency gains, they also create significant risks and uncertainty. The potential and perils of AI have thus come to dominate modern discussions of technology and ethics – and although AI was initially allowed to largely develop without guidelines or rules, few would deny that the law is set to play a fundamental role in shaping the future of AI. As the debate over AI is far from over, the need for rigorous analysis has never been greater. This book thus brings together contributors from different fields and backgrounds to explore how the law might provide answers to some of the most pressing questions raised by AI. An outcome of the Católica Research Centre for the Future of Law and its interdisciplinary working group on Law and Artificial Intelligence, it includes contributions by leading scholars in the fields of technology, ethics and the law.info:eu-repo/semantics/publishedVersio

    Communicating a Pandemic

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    This edited volume compares experiences of how the Covid-19 pandemic was communicated in the Nordic countries – Denmark, Finland, Iceland, Norway, and Sweden. The Nordic countries are often discussed in terms of similarities concerning an extensive welfare system, economic policies, media systems, and high levels of trust in societal actors. However, in the wake of a global pandemic, the countries’ coping strategies varied, creating certain question marks on the existence of a “Nordic model”. The chapters give a broad overview of crisis communication in the Nordic countries during the first year of the Covid-19 pandemic by combining organisational and societal theoretical perspectives and encompassing crisis response from governments, public health authorities, lobbyists, corporations, news media, and citizens. The results show several similarities, such as political and governmental responses highlighting solidarity and the need for exceptional measures, as expressed in press conferences, social media posts, information campaigns, and speeches. The media coverage relied on experts and was mainly informative, with few critical investigations during the initial phases. Moreover, surveys and interviews show the importance of news media for citizens’ coping strategies, but also that citizens mostly trusted both politicians and health authorities during the crisis. This book is of interest to all who are looking to understand societal crisis management on a comprehensive level. The volume contains chapters from leading experts from all the Nordic countries and is edited by a team with complementary expertise on crisis communication, political communication, and journalism, consisting of Bengt Johansson, Øyvind Ihlen, Jenny Lindholm, and Mark Blach-Ørsten. Publishe

    Parental risk and resilience: How does evidence inform child maltreatment prevention and reduction?

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    Child Maltreatment is a global concern with a sequela of negative consequences. The Risk and Resilience Ecological Framework is used to enable synthesis of evidence from two systematic reviews, A and B, on evidence of factors that influence parental child maltreatment. Review A comprises non-interventional, empirical studies to determine parental risk and protective factor interplay, lending support to causal and correlational links to child maltreatment. Review B synthesises evidence from intervention evaluations on parental risk factors and intervention provision for child maltreatment. A total of 128 studies, 68 observational studies in Review A and 60 intervention evaluations in Review B, were systematically reviewed. Quality appraisal did not lead to exclusion of studies. Review A findings mirror prior evidence and highlight nuances such as memories of parental childhood maltreatment as risk, emotional support for mothers and companionship support for fathers as protective, and demarcate maltreatment type-specific factors, especially for physical abuse and neglect. A low representation of fathers, under-research of unique factors for sexual and emotional abuse and of macro-level protective factors were identified. Review B provides comprehensive data on potentially effective intervention components including child development education and parental emotional regulation. Behaviour Change Techniques Framework helped identify potentially optimal delivery techniques including Instruction on how to perform a behaviour and Social support (unspecified). Lack of cultural representation, sparsity of interventions targeting fathers, over-reliance on self-reporting measures and under-examination of macro-level intervention components were identified as gaps in knowledge. Both reviews underline a call for consensus in definitions and avoidance of umbrella terms. A final synthesis elucidated the complex interplay of multiple influences on parental child maltreatment. Findings offer valuable insight to move the field forward, inform researchers, policy, and practice to strengthen parental resilience to prevent and reduce child maltreatment

    Vector-Processing for Mobile Devices: Benchmark and Analysis

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    Vector processing has become commonplace in today's CPU microarchitectures. Vector instructions improve performance and energy which is crucial for resource-constraint mobile devices. The research community currently lacks a comprehensive benchmark suite to study the benefits of vector processing for mobile devices. This paper presents Swan-an extensive vector processing benchmark suite for mobile applications. Swan consists of a diverse set of data-parallel workloads from four commonly used mobile applications: operating system, web browser, audio/video messaging application, and PDF rendering engine. Using Swan benchmark suite, we conduct a detailed analysis of the performance, power, and energy consumption of vectorized workloads, and show that: (a) Vectorized kernels increase the pressure on cache hierarchy due to the higher rate of memory requests. (b) Vector processing is more beneficial for workloads with lower precision operations and higher cache hit rates. (c) Limited Instruction-Level Parallelism and strided memory accesses to multi-dimensional data structures prevent vector processing benefits from scaling with more SIMD functional units and wider registers. (d) Despite lower computation throughput than domain-specific accelerators, such as GPU, vector processing outperforms these accelerators for kernels with lower operation counts. Finally, we show five common computation patterns in mobile data-parallel workloads that dominate the execution time.Comment: 2023 IEEE International Symposium on Workload Characterization (IISWC

    Motivational support intervention to reduce smoking and increase physical activity in smokers not ready to quit: the TARS RCT.

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    BACKGROUND: Physical activity can support smoking cessation for smokers wanting to quit, but there have been no studies on supporting smokers wanting only to reduce. More broadly, the effect of motivational support for such smokers is unclear. OBJECTIVES: The objectives were to determine if motivational support to increase physical activity and reduce smoking for smokers not wanting to immediately quit helps reduce smoking and increase abstinence and physical activity, and to determine if this intervention is cost-effective. DESIGN: This was a multicentred, two-arm, parallel-group, randomised (1 : 1) controlled superiority trial with accompanying trial-based and model-based economic evaluations, and a process evaluation. SETTING AND PARTICIPANTS: Participants from health and other community settings in four English cities received either the intervention (n = 457) or usual support (n = 458). INTERVENTION: The intervention consisted of up to eight face-to-face or telephone behavioural support sessions to reduce smoking and increase physical activity. MAIN OUTCOME MEASURES: The main outcome measures were carbon monoxide-verified 6- and 12-month floating prolonged abstinence (primary outcome), self-reported number of cigarettes smoked per day, number of quit attempts and carbon monoxide-verified abstinence at 3 and 9 months. Furthermore, self-reported (3 and 9 months) and accelerometer-recorded (3 months) physical activity data were gathered. Process items, intervention costs and cost-effectiveness were also assessed. RESULTS: The average age of the sample was 49.8 years, and participants were predominantly from areas with socioeconomic deprivation and were moderately heavy smokers. The intervention was delivered with good fidelity. Few participants achieved carbon monoxide-verified 6-month prolonged abstinence [nine (2.0%) in the intervention group and four (0.9%) in the control group; adjusted odds ratio 2.30 (95% confidence interval 0.70 to 7.56)] or 12-month prolonged abstinence [six (1.3%) in the intervention group and one (0.2%) in the control group; adjusted odds ratio 6.33 (95% confidence interval 0.76 to 53.10)]. At 3 months, the intervention participants smoked fewer cigarettes than the control participants (21.1 vs. 26.8 per day). Intervention participants were more likely to reduce cigarettes by ≄ 50% by 3 months [18.9% vs. 10.5%; adjusted odds ratio 1.98 (95% confidence interval 1.35 to 2.90] and 9 months [14.4% vs. 10.0%; adjusted odds ratio 1.52 (95% confidence interval 1.01 to 2.29)], and reported more moderate-to-vigorous physical activity at 3 months [adjusted weekly mean difference of 81.61 minutes (95% confidence interval 28.75 to 134.47 minutes)], but not at 9 months. Increased physical activity did not mediate intervention effects on smoking. The intervention positively influenced most smoking and physical activity beliefs, with some intervention effects mediating changes in smoking and physical activity outcomes. The average intervention cost was estimated to be ÂŁ239.18 per person, with an overall additional cost of ÂŁ173.50 (95% confidence interval -ÂŁ353.82 to ÂŁ513.77) when considering intervention and health-care costs. The 1.1% absolute between-group difference in carbon monoxide-verified 6-month prolonged abstinence provided a small gain in lifetime quality-adjusted life-years (0.006), and a minimal saving in lifetime health-care costs (net saving ÂŁ236). CONCLUSIONS: There was no evidence that behavioural support for smoking reduction and increased physical activity led to meaningful increases in prolonged abstinence among smokers with no immediate plans to quit smoking. The intervention is not cost-effective. LIMITATIONS: Prolonged abstinence rates were much lower than expected, meaning that the trial was underpowered to provide confidence that the intervention doubled prolonged abstinence. FUTURE WORK: Further research should explore the effects of the present intervention to support smokers who want to reduce prior to quitting, and/or extend the support available for prolonged reduction and abstinence. TRIAL REGISTRATION: This trial is registered as ISRCTN47776579. FUNDING: This project was funded by the National Institute for Health Research (NIHR) Health Technology Assessment programme and will be published in full in Health Technology Assessment; Vol. 27, No. 4. See the NIHR Journals Library website for further project information

    Understanding the Molecular Mechanism of Single-Strand Annealing Homologous DNA Recombination in Viruses, by Cryo-Electron Microscopy

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    The single-strand annealing homologous recombination (SSA) is one of the dsDNA break repair pathways, and albeit its importance from bacteria to bacteriophages, its molecular function is still unknown. The SSA reaction is catalysed by the enzyme complexes known as Exonuclease Annealase Two-component Recombinase (EATRs). The RecT and ORF6 proteins are single-stranded DNA-binding and annealing proteins expressed in E. coli and Kaposi’s sarcoma-associated herpesvirus (KSHV), respectively. RecT has already been shown to catalyse the SSA reaction. Although ORF6 has been shown to bind to ssDNA, further experimental evidence is needed to solidify its annealase activity. Since structure can dictate the function, this thesis aimed to determine the structure of the annealases RecT and ORF6 using a state-in-art cryo-electron microscopy technique. Furthermore, the shadow-casting EM technique has been established by optimising it for the equipment available at UOW, which is helpful for imaging the substrate DNA intermediates and the nucleoprotein complexes formed during SSA to better understand the molecular mechanistic details of this reaction. This thesis includes the details about RecT and ORF6 proteins’ cloning, expression, and purification, which were further optimised for purity and homogeneity for cryo-electron microscopy with the help of negative staining electron microscopy (NSEM). Additionally, based on several NSEM analyses, the C-terminal His-tag containing RecT (RecTCH) oligomerisation on ssDNA was studied, and a general mechanism of its oligomerisation is described. Unfortunately, during the RecTCH protein’s cryo-EM sample optimisation, the LiRecT structure was published by another group. Therefore, work on that project was ceased at that point. Several novel findings on ORF6 are reported in this thesis. Primarily, the concentration of the purified protein was increased 3 times more than the reports in the literature. Based on the NSEM and preliminary cryo-EM map of ORF6, it is shown that the ORF6 structure overall resembles the HSV1-ICP8 protein. Further, based on the steady-state and time-resolved fluorescence resonance energy transfer (FRET) experiments, a model for the ORF6 annealing mechanism is suggested. Towards generating a high-resolution structure, ORF6 monomers and filaments were optimised and imaged by using cryo-EM. Processing a data set obtained from a monomeric ORF6 sample showed the presence of conformational heterogeneity in the particles, which was expected as the ORF6 AlphaFold model shows that the N-terminal and C-terminal domains are connected by an 18 amino acids long loop, allowing C-terminal domain to be relatively flexible to move around. Processing of another data set obtained from a sample containing ORF6 filaments generated 2-dimensional averages that look promising for generating a high-resolution structure. This thesis also shows the details related to the installation and optimisation of the shadowing technique using a modern material, graphene oxide (GO), as a support film. This technique involves optimising both sample preparation and instrumentation for metal evaporation and deposition. For sample preparation, GO was deposited on cryo-EM holey grids, on which the sample was mounted. For instrumentation optimisation, a DENTON brand evaporator was used. The grid stage was re-engineered using AutoCAD to achieve the finest metal evaporation, and parameters such as amperage, vacuum, metal thickness, and angles were optimised. The optimised parameters were used to shadow-cast different lengths of DNA and their complexes with proteins, and good contrast images were acquired for qualitative and quantitative analyses. Overall, this thesis presents two main novel findings. First, RecTCH monomers oligomerise into an open ring-shaped structure, which stacks together to generate short filaments. Second, to anneal two complementary ssDNA strands, ORF6 first forms filaments with both ssDNA, which then come in contact with each other rapidly to anneal the complementary strands. Once the annealing finishes, the annealed dsDNA is released from the filaments as the filaments fall apart into monomers. We also found that ORF6 monomers oligomerise to form the helical and non-helical filaments in the presence of DTT+Mg2+ and DTT-containing buffer, respectively

    Examining the Relationships Between Distance Education Students’ Self-Efficacy and Their Achievement

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    This study aimed to examine the relationships between students’ self-efficacy (SSE) and students’ achievement (SA) in distance education. The instruments were administered to 100 undergraduate students in a distance university who work as migrant workers in Taiwan to gather data, while their SA scores were obtained from the university. The semi-structured interviews for 8 participants consisted of questions that showed the specific conditions of SSE and SA. The findings of this study were reported as follows: There was a significantly positive correlation between targeted SSE (overall scales and general self-efficacy) and SA. Targeted students' self-efficacy effectively predicted their achievement; besides, general self- efficacy had the most significant influence. In the qualitative findings, four themes were extracted for those students with lower self-efficacy but higher achievement—physical and emotional condition, teaching and learning strategy, positive social interaction, and intrinsic motivation. Moreover, three themes were extracted for those students with moderate or higher self-efficacy but lower achievement—more time for leisure (not hard-working), less social interaction, and external excuses. Providing effective learning environments, social interactions, and teaching and learning strategies are suggested in distance education

    The effectiveness and cost-effectiveness of upper limb prostheses

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    The cost of upper limb prostheses related health care are rising. One reason may be the more frequent prescription of the expensive multi-grip myoelectric hand prostheses. However, signs of non-usage of the additional grip options of these hands are described. In these cases, a more simple prosthesis might also suit the users’ needs. Therefore, we investigated: 1. Factors that affect prosthesis choice and use A qualitative meta-synthesis, focus group and a nationwide survey in which 358 participants selected their top-10 most important items regarding prosthesis use were performed. Based on these results, a measurement tool, the PUF-ULP, was developed, which provides a single score that represents the match between the user and their prosthesis. 2. Cost-effectiveness of upper limb prosthesis A total of 242 upper limb prostheses users completed a quality of life questionnaire, the PUF-ULP, and a cost questionnaire. Results indicated that myoelectric prostheses, especially the multi-grip ones, are the most expensive compared to other prostheses types, while no differences in quality of life or user experiences were apparent. 3. Multi-grip versus standard myoelectric hands Fourteen multi-grip myoelectric hand prosthesis users performed multiple tests with both the multi-grip and standard myoelectric hand. Additionally, the users’ experiences of the multi-grip myoelectric hand prostheses were compared with these of 19 standard myoelectric hand prosthesis users using questionnaires. Results showed no relevant advantages of the multi-grip hand over the standard hand. 4. Development decision aidIn a systematic co-creation process a decision aid about hand prosthesis was developed and implemented nationwide
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