A Proximity-Aware Hierarchical Clustering of Faces

In this paper, we propose an unsupervised face clustering algorithm called "Proximity-Aware Hierarchical Clustering" (PAHC) that exploits the local structure of deep representations. In the proposed method, a similarity measure between deep features is computed by evaluating linear SVM margins. SVMs are trained using nearest neighbors of sample data, and thus do not require any external training data. Clusters are then formed by thresholding the similarity scores. We evaluate the clustering performance using three challenging unconstrained face datasets, including Celebrity in Frontal-Profile (CFP), IARPA JANUS Benchmark A (IJB-A), and JANUS Challenge Set 3 (JANUS CS3) datasets. Experimental results demonstrate that the proposed approach can achieve significant improvements over state-of-the-art methods. Moreover, we also show that the proposed clustering algorithm can be applied to curate a set of large-scale and noisy training dataset while maintaining sufficient amount of images and their variations due to nuisance factors. The face verification performance on JANUS CS3 improves significantly by finetuning a DCNN model with the curated MS-Celeb-1M dataset which contains over three million face images

Methods for protein complex prediction and their contributions towards understanding the organization, function and dynamics of complexes

Complexes of physically interacting proteins constitute fundamental functional units responsible for driving biological processes within cells. A faithful reconstruction of the entire set of complexes is therefore essential to understand the functional organization of cells. In this review, we discuss the key contributions of computational methods developed till date (approximately between 2003 and 2015) for identifying complexes from the network of interacting proteins (PPI network). We evaluate in depth the performance of these methods on PPI datasets from yeast, and highlight challenges faced by these methods, in particular detection of sparse and small or sub- complexes and discerning of overlapping complexes. We describe methods for integrating diverse information including expression profiles and 3D structures of proteins with PPI networks to understand the dynamics of complex formation, for instance, of time-based assembly of complex subunits and formation of fuzzy complexes from intrinsically disordered proteins. Finally, we discuss methods for identifying dysfunctional complexes in human diseases, an application that is proving invaluable to understand disease mechanisms and to discover novel therapeutic targets. We hope this review aptly commemorates a decade of research on computational prediction of complexes and constitutes a valuable reference for further advancements in this exciting area.Comment: 1 Tabl