Abstraction of Elementary Hybrid Systems by Variable Transformation

Elementary hybrid systems (EHSs) are those hybrid systems (HSs) containing elementary functions such as exp, ln, sin, cos, etc. EHSs are very common in practice, especially in safety-critical domains. Due to the non-polynomial expressions which lead to undecidable arithmetic, verification of EHSs is very hard. Existing approaches based on partition of state space or over-approximation of reachable sets suffer from state explosion or inflation of numerical errors. In this paper, we propose a symbolic abstraction approach that reduces EHSs to polynomial hybrid systems (PHSs), by replacing all non-polynomial terms with newly introduced variables. Thus the verification of EHSs is reduced to the one of PHSs, enabling us to apply all the well-established verification techniques and tools for PHSs to EHSs. In this way, it is possible to avoid the limitations of many existing methods. We illustrate the abstraction approach and its application in safety verification of EHSs by several real world examples

From Electric Circuits to Chemical Networks

Electric circuits manipulate electric charge and magnetic flux via a small set of discrete components to implement useful functionality over continuous time-varying signals represented by currents and voltages. Much of the same functionality is useful to biological organisms, where it is implemented by a completely different set of discrete components (typically proteins) and signal representations (typically via concentrations). We describe how to take a linear electric circuit and systematically convert it to a chemical reaction network of the same functionality, as a dynamical system. Both the structure and the components of the electric circuit are dissolved in the process, but the resulting chemical network is intelligible. This approach provides access to a large library of well-studied devices, from analog electronics, whose chemical network realization can be compared to natural biochemical networks, or used to engineer synthetic biochemical networks