Euskarazko artikuluaren sintaxiaz

This work tries to identify th specific semantic contribution and syntactic position of the article in Basque. The analysis centers on absolutive marked Determiner Phrases.Lan honetan euskal artikuluaren balio espezifikoa aztertzen da, determinatzaile sintagmak betetzen duen lekuan, duen funtzioan eta aurkezten duen hitz hurrenkeran oinarrituz, eta analisia, beti ere, absolutiboz markaturik agertzen diren sintagmetara mugatuaz

Euskarazko artikuluaren sintaxiaz

This work tries to identify th specific semantic contribution and syntactic position of the article in Basque. The analysis centers on absolutive marked Determiner Phrases.Lan honetan euskal artikuluaren balio espezifikoa aztertzen da, determinatzaile sintagmak betetzen duen lekuan, duen funtzioan eta aurkezten duen hitz hurrenkeran oinarrituz, eta analisia, beti ere, absolutiboz markaturik agertzen diren sintagmetara mugatuaz

AURKA mRNA expression is an independent predictor of poor prognosis in patients with non-small cell lung cancer

Deregulation of mitotic spindle genes has been reported to contribute to the development and progression of malignant tumours. The aim of the present study was to explore the association between the expression profiles of Aurora kinases (AURKA, AURKB and AURKC), cytoskeleton-associated protein 5 (CKAP5), discs large-associated protein 5 (DLGAP5), kinesin-like protein 11 (KIF11), microtubule nucleation factor (TPX2), monopolar spindle 1 kinase (TTK), and β-tubulins (TUBB) and (TUBB3) genes and clinicopathological characteristics in human non-small cell lung carcinoma (NSCLC). Reverse transcription-quantitative polymerase chain reaction-based RNA gene expression profiles of 132 NSCLC and 44 adjacent wild-type tissues were generated, and Cox's proportional hazard regression was used to examine associations. With the exception of AURKC, all genes exhibited increased expression in NSCLC tissues. Of the 10 genes examined, only AURKA was significantly associated with prognosis in NSCLC. Multivariate Cox's regression analysis demonstrated that AURKA mRNA expression [hazard ratio (HR), 1.81; 95% confidence interval (CI), 1.16-2.84; P=0.009], age (HR, 1.03; 95% CI, 1.00-1.06; P=0.020), pathological tumour stage 2 (HR, 2.43; 95% CI, 1.16-5.10; P=0.019) and involvement of distal nodes (pathological node stage 2) (HR, 3.14; 95% CI, 1.24-7.99; P=0.016) were independent predictors of poor prognosis in patients with NSCLC. Poor prognosis of patients with increased AURKA expression suggests that those patients may benefit from surrogate therapy with AURKA inhibitors

Is GRO J1744-28 a Strange Star?

The unusal hard x-ray burster GRO J1744-28 recently discovered by the Compton Gamma-ray Observatory (GRO) can be modeled as a strange star with a dipolar magnetic field $\le 10^{11}$Gauss. When the accreted mass of the star exceeds some critical mass, its crust may break, resulting in conversion of the accreted matter into strange matter and release of energy. Subsequently, a fireball may form and expand relativistically outward. The expanding fireball may interact with the surrounding interstellar medium, causing its kinetic energy to be radiated in shock waves, producing a burst of x-ray radiation. The burst energy, duration, interval and spectrum derived from such a model are consistent with the observations of GRO J1744-28.Comment: Latex, has been published in SCIENCE, Vol. 280, 40

A note on Fontaine theory using different Lubin-Tate groups

Using different Lubin-Tate groups, we compare $(\phi, \Gamma)$ modules associated to a Galois representation via Fontaine's theory

Legislació sobre les guaites de la Universitat de Sant Andreu i Sant Vicenç de Llavaneres

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Spartan Daily, March 1, 1955

Volume 42, Issue 98https://scholarworks.sjsu.edu/spartandaily/12147/thumbnail.jp

Spartan Daily, October 8, 1951

Volume 40, Issue 9https://scholarworks.sjsu.edu/spartandaily/11596/thumbnail.jp

New compound sets identified from high throughput phenotypic screening against three kinetoplastid parasites:an open resource

Using whole-cell phenotypic assays, the GlaxoSmithKline high-throughput screening (HTS) diversity set of 1.8 million compounds was screened against the three kinetoplastids most relevant to human disease, i.e. Leishmania donovani, Trypanosoma cruzi and Trypanosoma brucei. Secondary confirmatory and orthogonal intracellular anti-parasiticidal assays were conducted, and the potential for non-specific cytotoxicity determined. Hit compounds were chemically clustered and triaged for desirable physicochemical properties. The hypothetical biological target space covered by these diversity sets was investigated through bioinformatics methodologies. Consequently, three anti-kinetoplastid chemical boxes of ~200 compounds each were assembled. Functional analyses of these compounds suggest a wide array of potential modes of action against kinetoplastid kinases, proteases and cytochromes as well as potential host–pathogen targets. This is the first published parallel high throughput screening of a pharma compound collection against kinetoplastids. The compound sets are provided as an open resource for future lead discovery programs, and to address important research questions.The support and funding of Tres Cantos Open Lab Foundation is gratefully acknowledgedPeer reviewe