Investigations on vinylene carbonate. V. Immobilization of alkaline phosphatase onto LDPE films cografted with vinylene carbonate and N-vinyl-N-methylacetamide

Low-density polyethylene (LDPE) films cografted with vinylene carbonate (VCA) and N-vinyl-N-methylacetamide (VIMA) were studied as a matrix for the immobilization of the enzyme alkaline phosphatase (ALP) either by direct fixation or by inserting spacers. When water-soluble alkyldiamines such as diaminoethylene, diaminobutane, diethylenetriamine, and diaminohexane were used as spacers between the matrix and the enzyme, the surface concentration (SC) of the active ALP coupled on the matrix was increased, whereas the effect of the spacer on the SC was dependent on the length of the spacer. Bovine serum albumin (BSA) was preimmobilized onto the LDPE films to provide a better simulation of the biological environment for the enzyme, and the SC of ALP on the matrix was significantly increased by coupling ALP onto the BSA preimmobilized surfaces. Compared to native ALP, some physicochemical properties of ALP could be improved by the covalent immobilization

Supersymmetry for Alp Hikers

These lectures provide a phenomenological introduction to supersymmetry, concentrating on the minimal supersymmetric extension of the Standard Model (MSSM). In the first lecture, motivations are provided for thinking that supersymmetry might appear at the TeV scale, including the naturalness of the mass hierarchy, gauge unification and the probable mass of the Higgs boson. In the second lecture, simple globally supersymmetric field theories are introduced, with the emphasis on features important for model-building. Supersymmetry breaking and local supersymmetry (supergravity) are introduced in the third lecture, and the structure of sparticle mass matrices and mixing are reviewed. Finally, the available experimental and cosmological constraints on MSSM parameters are discussed and combined in the fourth lecture, and the prospects for discovering supersymmetry in future experiments are previewed.Comment: 45 pages, 19 figures, Lectures at the European School of High-Energy Physics, Beatenberg, Switzerland, 26 Aug - 8 Sept 200

Coupling QCD-scale axion-like particles to gluons

We present a novel data-driven method for determining the hadronic interaction strengths of axion-like particles (ALPs) with QCD-scale masses. Using our method, it is possible to calculate the hadronic production and decay rates of ALPs, along with many of the largest ALP decay rate to exclusive final states. To illustrate the impact on QCD-scale ALP phenomenology, we consider the scenario where the ALP-gluon coupling is dominant over the ALP coupling to photons, electroweak bosons, and all fermions for $m_{\pi} \lesssim m_a \lesssim 3$ GeV. We emphasize, however, that our method can easily be generalized to any set of ALP couplings to SM particles. Finally, using the approach developed here, we provide calculations for the branching fractions of $\eta_c \to VV$ decays, i.e. $\eta_c$ decays into two vector mesons, which are consistent with the known experimental values.Comment: 19 pages, 7 figures; v3 Fig 4 updated to account for a small change in the limit taken from [1903.03586

The Study of Serum Prostate Specific Antigen and Phosphatase Isoenzymes Activity as Diagnostic Parameters in Patients with Prostate Cancer in Nigeria

Serum activities of Acid Phosphatase (ACP) and Prostatic Acid Phosphatase (PAP) are still employed in most hospitals in Nigeria for the diagnosis of prostate cancer, because of lack of resources for prostate specific antigen (PSA) assay. Serum PSA and activities of phosphatase isoenzymes ACP and PAP, Alkaline Phosphatase (ALP) and Heat stable Alkaline Phosphatase (HSAP) were studied in 71 apparently healthy male controls and 47 proven prostate cancer patients. There were statistically significant increases in the mean serum levels of PSA, PAP, ACP, ALP and HSAP in the prostate cancer patients compared to the controls (P<0.001). PSA level was increased above the cut-off level in 85.1% of patients, PAP in 66.0%, ACP in 57.5%, ALP in 34.0% and HSAP in 21.3% of cases. Serum levels of PSA, ACP and PAP were lower and of ALP and HSAP higher in patients with longer duration of the disease (P<0.05). The study confirms the relevance of PSA assay over ACP, PAP, ALP and HSAP in the diagnosis of prostate cancer patients. It highlights the need for the inclusion of PSA assay in hospitals for accurate diagnosis of prostatic carcinoma

Adiabatic Electroweak Baryogenesis Driven by an Axion-like Particle

An axion-like particle (ALP) offers a new direction in electroweak baryogenesis because the periodic nature enables it to trigger a strong first-order phase transition insensitively to the decay constant $f$. For $f$ much above TeV, the ALP-induced electroweak phase transition is approximately described by adiabatic processes, distinguishing our scenario for electroweak baryogenesis from the conventional ones. We show that, coupled to the electroweak anomaly, the ALP can naturally realize spontaneous electroweak baryogenesis to solve the matter-antimatter asymmetry problem for $f$ in the range between about $10^5$ GeV and $10^7$ GeV. In such an ALP window, the $CP$ violation for baryogenesis is totally free from the experimental constraints, especially from the recently improved limit on the electron electric dipole moment. Future searches for ALPs could probe our scenario while revealing the connection between electroweak symmetry breaking and baryogenesis.Comment: 12 pages, 5 figures, appendices added, published versio

The Quantum Liquid of Alpha Clusters

Within the variational approach of Bose liquids we analyze the g.s. energy of charge neutral alpha matter at $T$=0. As a prerequisite for such calculation we take from the literature or propose new \alp-\alp potentials that are particularly suitable for this task, i.e. posses a repulsive core and/or reproduce the low energy scattering data and the resonance properties of the \alp-\alp system. The alpha matter EOS is then obtained with the HNC method using Pandharipande-Bethe correlation derived variationally in the lowest order expansion of the energy functional or a simple gaussian function with a healing range determined by the normalization of the radial distribution function in the lowest order. We show that saturation is achieved only via repulsive and shallow potentials that are not consistent with the scattering and resonance constraints.Comment: 8 pages, 4 figure