35,063 research outputs found
A Survey on Array Storage, Query Languages, and Systems
Since scientific investigation is one of the most important providers of
massive amounts of ordered data, there is a renewed interest in array data
processing in the context of Big Data. To the best of our knowledge, a unified
resource that summarizes and analyzes array processing research over its long
existence is currently missing. In this survey, we provide a guide for past,
present, and future research in array processing. The survey is organized along
three main topics. Array storage discusses all the aspects related to array
partitioning into chunks. The identification of a reduced set of array
operators to form the foundation for an array query language is analyzed across
multiple such proposals. Lastly, we survey real systems for array processing.
The result is a thorough survey on array data storage and processing that
should be consulted by anyone interested in this research topic, independent of
experience level. The survey is not complete though. We greatly appreciate
pointers towards any work we might have forgotten to mention.Comment: 44 page
Visualization and Correction of Automated Segmentation, Tracking and Lineaging from 5-D Stem Cell Image Sequences
Results: We present an application that enables the quantitative analysis of
multichannel 5-D (x, y, z, t, channel) and large montage confocal fluorescence
microscopy images. The image sequences show stem cells together with blood
vessels, enabling quantification of the dynamic behaviors of stem cells in
relation to their vascular niche, with applications in developmental and cancer
biology. Our application automatically segments, tracks, and lineages the image
sequence data and then allows the user to view and edit the results of
automated algorithms in a stereoscopic 3-D window while simultaneously viewing
the stem cell lineage tree in a 2-D window. Using the GPU to store and render
the image sequence data enables a hybrid computational approach. An
inference-based approach utilizing user-provided edits to automatically correct
related mistakes executes interactively on the system CPU while the GPU handles
3-D visualization tasks. Conclusions: By exploiting commodity computer gaming
hardware, we have developed an application that can be run in the laboratory to
facilitate rapid iteration through biological experiments. There is a pressing
need for visualization and analysis tools for 5-D live cell image data. We
combine accurate unsupervised processes with an intuitive visualization of the
results. Our validation interface allows for each data set to be corrected to
100% accuracy, ensuring that downstream data analysis is accurate and
verifiable. Our tool is the first to combine all of these aspects, leveraging
the synergies obtained by utilizing validation information from stereo
visualization to improve the low level image processing tasks.Comment: BioVis 2014 conferenc
Target and (Astro-)WISE technologies - Data federations and its applications
After its first implementation in 2003 the Astro-WISE technology has been
rolled out in several European countries and is used for the production of the
KiDS survey data. In the multi-disciplinary Target initiative this technology,
nicknamed WISE technology, has been further applied to a large number of
projects. Here, we highlight the data handling of other astronomical
applications, such as VLT-MUSE and LOFAR, together with some non-astronomical
applications such as the medical projects Lifelines and GLIMPS, the MONK
handwritten text recognition system, and business applications, by amongst
others, the Target Holding. We describe some of the most important lessons
learned and describe the application of the data-centric WISE type of approach
to the Science Ground Segment of the Euclid satellite.Comment: 9 pages, 5 figures, Proceedngs IAU Symposium No 325 Astroinformatics
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1st INCF Workshop on Sustainability of Neuroscience Databases
The goal of the workshop was to discuss issues related to the sustainability of neuroscience databases, identify problems and propose solutions, and formulate recommendations to the INCF. The report summarizes the discussions of invited participants from the neuroinformatics community as well as from other disciplines where sustainability issues have already been approached. The recommendations for the INCF involve rating, ranking, and supporting database sustainability
Pathways: Augmenting interoperability across scholarly repositories
In the emerging eScience environment, repositories of papers, datasets,
software, etc., should be the foundation of a global and natively-digital
scholarly communications system. The current infrastructure falls far short of
this goal. Cross-repository interoperability must be augmented to support the
many workflows and value-chains involved in scholarly communication. This will
not be achieved through the promotion of single repository architecture or
content representation, but instead requires an interoperability framework to
connect the many heterogeneous systems that will exist.
We present a simple data model and service architecture that augments
repository interoperability to enable scholarly value-chains to be implemented.
We describe an experiment that demonstrates how the proposed infrastructure can
be deployed to implement the workflow involved in the creation of an overlay
journal over several different repository systems (Fedora, aDORe, DSpace and
arXiv).Comment: 18 pages. Accepted for International Journal on Digital Libraries
special issue on Digital Libraries and eScienc
Traction force microscopy on soft elastic substrates: a guide to recent computational advances
The measurement of cellular traction forces on soft elastic substrates has
become a standard tool for many labs working on mechanobiology. Here we review
the basic principles and different variants of this approach. In general, the
extraction of the substrate displacement field from image data and the
reconstruction procedure for the forces are closely linked to each other and
limited by the presence of experimental noise. We discuss different strategies
to reconstruct cellular forces as they follow from the foundations of
elasticity theory, including two- versus three-dimensional, inverse versus
direct and linear versus non-linear approaches. We also discuss how biophysical
models can improve force reconstruction and comment on practical issues like
substrate preparation, image processing and the availability of software for
traction force microscopy.Comment: Revtex, 29 pages, 3 PDF figures, 2 tables. BBA - Molecular Cell
Research, online since 27 May 2015, special issue on mechanobiolog
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