24,591 research outputs found
Multiobjective strategies for New Product Development in the pharmaceutical industry
New Product Development (NPD) constitutes a challenging problem in the pharmaceutical industry, due to the characteristics of the development pipeline. Formally, the NPD problem can be stated as follows: select a set of R&D projects from a pool of candidate projects in order to satisfy several criteria (economic profitability, time to market) while coping with the uncertain nature of the projects. More precisely, the recurrent key issues are to determine the projects to develop once target molecules have been identified, their order and the level of resources to assign. In this context, the proposed approach combines discrete event stochastic simulation (Monte Carlo approach) with multiobjective genetic algorithms (NSGAII type, Non-Sorted Genetic Algorithm II) to optimize the highly combinatorial portfolio management problem. In that context, Genetic Algorithms (GAs) are particularly attractive for treating this kind of problem, due to their ability to directly lead to the so-called Pareto front and to account for the combinatorial aspect. This work is illustrated with a study case involving nine interdependent new product candidates targeting three diseases. An analysis is performed for this test bench on the different pairs of criteria both for the bi- and tricriteria optimization: large portfolios cause resource queues and delays time to launch and are eliminated by the bi- and tricriteria optimization strategy. The optimization strategy is thus interesting to detect the sequence candidates. Time is an important criterion to consider simultaneously with NPV and risk criteria. The order in which drugs are released in the pipeline is of great importance as with scheduling problems
Multiobjective strategies for New Product Development in the pharmaceutical industry
New Product Development (NPD) constitutes a challenging problem in the pharmaceutical industry, due to the characteristics of the development pipeline. Formally, the NPD problem can be stated as follows: select a set of R&D projects from a pool of candidate projects in order to satisfy several criteria (economic profitability, time to market) while coping with the uncertain nature of the projects. More precisely, the recurrent key issues are to determine the projects to develop once target molecules have been identified, their order and the level of resources to assign. In this context, the proposed approach combines discrete event stochastic simulation (Monte Carlo approach) with multiobjective genetic algorithms (NSGAII type, Non-Sorted Genetic Algorithm II) to optimize the highly combinatorial portfolio management problem. In that context, Genetic Algorithms (GAs) are particularly attractive for treating this kind of problem, due to their ability to directly lead to the so-called Pareto front and to account for the combinatorial aspect. This work is illustrated with a study case involving nine interdependent new product candidates targeting three diseases. An analysis is performed for this test bench on the different pairs of criteria both for the bi- and tricriteria optimization: large portfolios cause resource queues and delays time to launch and are eliminated by the bi- and tricriteria optimization strategy. The optimization strategy is thus interesting to detect the sequence candidates. Time is an important criterion to consider simultaneously with NPV and risk criteria. The order in which drugs are released in the pipeline is of great importance as with scheduling problems
Denoising Autoencoders for fast Combinatorial Black Box Optimization
Estimation of Distribution Algorithms (EDAs) require flexible probability
models that can be efficiently learned and sampled. Autoencoders (AE) are
generative stochastic networks with these desired properties. We integrate a
special type of AE, the Denoising Autoencoder (DAE), into an EDA and evaluate
the performance of DAE-EDA on several combinatorial optimization problems with
a single objective. We asses the number of fitness evaluations as well as the
required CPU times. We compare the results to the performance to the Bayesian
Optimization Algorithm (BOA) and RBM-EDA, another EDA which is based on a
generative neural network which has proven competitive with BOA. For the
considered problem instances, DAE-EDA is considerably faster than BOA and
RBM-EDA, sometimes by orders of magnitude. The number of fitness evaluations is
higher than for BOA, but competitive with RBM-EDA. These results show that DAEs
can be useful tools for problems with low but non-negligible fitness evaluation
costs.Comment: corrected typos and small inconsistencie
Multi-rendezvous Spacecraft Trajectory Optimization with Beam P-ACO
The design of spacecraft trajectories for missions visiting multiple
celestial bodies is here framed as a multi-objective bilevel optimization
problem. A comparative study is performed to assess the performance of
different Beam Search algorithms at tackling the combinatorial problem of
finding the ideal sequence of bodies. Special focus is placed on the
development of a new hybridization between Beam Search and the Population-based
Ant Colony Optimization algorithm. An experimental evaluation shows all
algorithms achieving exceptional performance on a hard benchmark problem. It is
found that a properly tuned deterministic Beam Search always outperforms the
remaining variants. Beam P-ACO, however, demonstrates lower parameter
sensitivity, while offering superior worst-case performance. Being an anytime
algorithm, it is then found to be the preferable choice for certain practical
applications.Comment: Code available at https://github.com/lfsimoes/beam_paco__gtoc
Chance-Constrained Outage Scheduling using a Machine Learning Proxy
Outage scheduling aims at defining, over a horizon of several months to
years, when different components needing maintenance should be taken out of
operation. Its objective is to minimize operation-cost expectation while
satisfying reliability-related constraints. We propose a distributed
scenario-based chance-constrained optimization formulation for this problem. To
tackle tractability issues arising in large networks, we use machine learning
to build a proxy for predicting outcomes of power system operation processes in
this context. On the IEEE-RTS79 and IEEE-RTS96 networks, our solution obtains
cheaper and more reliable plans than other candidates
XOR-Sampling for Network Design with Correlated Stochastic Events
Many network optimization problems can be formulated as stochastic network
design problems in which edges are present or absent stochastically.
Furthermore, protective actions can guarantee that edges will remain present.
We consider the problem of finding the optimal protection strategy under a
budget limit in order to maximize some connectivity measurements of the
network. Previous approaches rely on the assumption that edges are independent.
In this paper, we consider a more realistic setting where multiple edges are
not independent due to natural disasters or regional events that make the
states of multiple edges stochastically correlated. We use Markov Random Fields
to model the correlation and define a new stochastic network design framework.
We provide a novel algorithm based on Sample Average Approximation (SAA)
coupled with a Gibbs or XOR sampler. The experimental results on real road
network data show that the policies produced by SAA with the XOR sampler have
higher quality and lower variance compared to SAA with Gibbs sampler.Comment: In Proceedings of the Twenty-sixth International Joint Conference on
Artificial Intelligence (IJCAI-17). The first two authors contribute equall
Aligning Multiple Sequences with Genetic Algorithm
The alignment of biological sequences is a crucial
tool in molecular biology and genome analysis. It helps to build
a phylogenetic tree of related DNA sequences and also to predict
the function and structure of unknown protein sequences by
aligning with other sequences whose function and structure is
already known. However, finding an optimal multiple sequence
alignment takes time and space exponential with the length or
number of sequences increases. Genetic Algorithms (GAs) are
strategies of random searching that optimize an objective
function which is a measure of alignment quality (distance) and
has the ability for exploratory search through the solution space
and exploitation of current results
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