2,921 research outputs found
Current and Future Challenges in Knowledge Representation and Reasoning
Knowledge Representation and Reasoning is a central, longstanding, and active
area of Artificial Intelligence. Over the years it has evolved significantly;
more recently it has been challenged and complemented by research in areas such
as machine learning and reasoning under uncertainty. In July 2022 a Dagstuhl
Perspectives workshop was held on Knowledge Representation and Reasoning. The
goal of the workshop was to describe the state of the art in the field,
including its relation with other areas, its shortcomings and strengths,
together with recommendations for future progress. We developed this manifesto
based on the presentations, panels, working groups, and discussions that took
place at the Dagstuhl Workshop. It is a declaration of our views on Knowledge
Representation: its origins, goals, milestones, and current foci; its relation
to other disciplines, especially to Artificial Intelligence; and on its
challenges, along with key priorities for the next decade
Design of new algorithms for gene network reconstruction applied to in silico modeling of biomedical data
Programa de Doctorado en BiotecnologĂa, IngenierĂa y TecnologĂa QuĂmicaLĂnea de InvestigaciĂłn: IngenierĂa, Ciencia de Datos y BioinformĂĄticaClave Programa: DBICĂłdigo LĂnea: 111The root causes of disease are still poorly understood. The success of current therapies is limited because persistent diseases are frequently treated based on their symptoms rather than the underlying cause of the disease. Therefore, biomedical research is experiencing a technology-driven shift to data-driven holistic approaches to better characterize the molecular mechanisms causing disease. Using omics data as an input, emerging disciplines like network biology attempt to model the relationships between biomolecules. To this effect, gene co- expression networks arise as a promising tool for deciphering the relationships between genes in large transcriptomic datasets. However, because of their low specificity and high false positive rate, they demonstrate a limited capacity to retrieve the disrupted mechanisms that lead to disease onset, progression, and maintenance. Within the context of statistical modeling, we dove deeper into the reconstruction of gene co-expression networks with the specific goal of discovering disease-specific features directly from expression data. Using ensemble techniques, which combine the results of various metrics, we were able to more precisely capture biologically significant relationships between genes. We were able to find de novo potential disease-specific features with the help of prior biological knowledge and the development of new network inference techniques.
Through our different approaches, we analyzed large gene sets across multiple samples and used gene expression as a surrogate marker for the inherent biological processes, reconstructing robust gene co-expression networks that are simple to explore. By mining disease-specific gene co-expression networks we come up with a useful framework for identifying new omics-phenotype associations from conditional expression datasets.In this sense, understanding diseases from the perspective of biological network perturbations will improve personalized medicine, impacting rational biomarker discovery, patient stratification and drug design, and ultimately leading to more targeted therapies.Universidad Pablo de Olavide de Sevilla. Departamento de Deporte e InformĂĄtic
Investigating the learning potential of the Second Quantum Revolution: development of an approach for secondary school students
In recent years we have witnessed important changes: the Second Quantum Revolution is in the spotlight of many countries, and it is creating a new generation of technologies.
To unlock the potential of the Second Quantum Revolution, several countries have launched strategic plans and research programs that finance and set the pace of research and development of these new technologies (like the Quantum Flagship, the National Quantum Initiative Act and so on).
The increasing pace of technological changes is also challenging science education and institutional systems, requiring them to help to prepare new generations of experts.
This work is placed within physics education research and contributes to the challenge by developing an approach and a course about the Second Quantum Revolution. The aims are to promote quantum literacy and, in particular, to value from a cultural and educational perspective the Second Revolution.
The dissertation is articulated in two parts. In the first, we unpack the Second Quantum Revolution from a cultural perspective and shed light on the main revolutionary aspects that are elevated to the rank of principles implemented in the design of a course for secondary school students, prospective and in-service teachers. The design process and the educational reconstruction of the activities are presented as well as the results of a pilot study conducted to investigate the impact of the approach on students' understanding and to gather feedback to refine and improve the instructional materials.
The second part consists of the exploration of the Second Quantum Revolution as a context to introduce some basic concepts of quantum physics. We present the results of an implementation with secondary school students to investigate if and to what extent external representations could play any role to promote studentsâ understanding and acceptance of quantum physics as a personal reliable description of the world
A Theistic Critique of Secular Moral Nonnaturalism
This dissertation is an exercise in Theistic moral apologetics. It will be developing both a critique of secular nonnaturalist moral theory (moral Platonism) at the level of metaethics, as well as a positive form of the moral argument for the existence of God that follows from this critique. The critique will focus on the work of five prominent metaethical theorists of secular moral non-naturalism: David Enoch, Eric Wielenberg, Russ Shafer-Landau, Michael Huemer, and Christopher Kulp. Each of these thinkers will be critically examined. Following this critique, the positive moral argument for the existence of God will be developed, combining a cumulative, abductive argument that follows from filling in the content of a succinct apagogic argument. The cumulative abductive argument and the apagogic argument together, with a transcendental and modal component, will be presented to make the case that Theism is the best explanation for the kind of moral, rational beings we are and the kind of universe in which we live, a rational intelligible universe
Semantic inconsistency measures using 3-valued logics
AI systems often need to deal with inconsistencies. One way of getting information about inconsistencies is by measuring the amount of information in the knowledgebase. In the past 20 years numerous inconsistency measures have been proposed. Many of these measures are syntactic measures, that is, they are based in some way on the minimal inconsistent subsets of the knowledgebase. Very little attention has been given to semantic inconsistency measures, that is, ones that are based on the models of the knowledgebase where the notion of a model is generalized to allow an atom to be assigned a truth value that denotes contradiction. In fact, only one nontrivial semantic inconsistency measure, the contension measure, has been in wide use. The purpose of this paper is to define a class of semantic inconsistency measures based on 3-valued logics. First, we show which 3-valued logics are useful for this purpose. Then we show that the class of semantic inconsistency measures can be developed using a graphical framework similar to the way that syntactic inconsistency measures have been studied. We give several examples of semantic inconsistency measures and show how they apply to three useful 3-valued logics. We also investigate the properties of these inconsistency measures and show their computation for several knowledgebases
Computational Approaches to Drug Profiling and Drug-Protein Interactions
Despite substantial increases in R&D spending within the pharmaceutical industry, denovo drug design has become a time-consuming endeavour. High attrition rates led to a
long period of stagnation in drug approvals. Due to the extreme costs associated with
introducing a drug to the market, locating and understanding the reasons for clinical failure
is key to future productivity. As part of this PhD, three main contributions were made in
this respect. First, the web platform, LigNFam enables users to interactively explore
similarity relationships between âdrug likeâ molecules and the proteins they bind. Secondly,
two deep-learning-based binding site comparison tools were developed, competing with
the state-of-the-art over benchmark datasets. The models have the ability to predict offtarget interactions and potential candidates for target-based drug repurposing. Finally, the
open-source ScaffoldGraph software was presented for the analysis of hierarchical scaffold
relationships and has already been used in multiple projects, including integration into a
virtual screening pipeline to increase the tractability of ultra-large screening experiments.
Together, and with existing tools, the contributions made will aid in the understanding of
drug-protein relationships, particularly in the fields of off-target prediction and drug
repurposing, helping to design better drugs faster
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A Survey of Quantum-Cognitively Inspired Sentiment Analysis Models
Quantum theory, originally proposed as a physical theory to describe the motions of microscopic particles, has been applied to various non-physics domains involving human cognition and decision-making that are inherently uncertain and exhibit certain non-classical, quantum-like characteristics. Sentiment analysis is a typical example of such domains. In the last few years, by leveraging the modeling power of quantum probability (a non-classical probability stemming from quantum mechanics methodology) and deep neural networks, a range of novel quantum-cognitively inspired models for sentiment analysis have emerged and performed well. This survey presents a timely overview of the latest developments in this fascinating cross-disciplinary area. We first provide a background of quantum probability and quantum cognition at a theoretical level, analyzing their advantages over classical theories in modeling the cognitive aspects of sentiment analysis. Then, recent quantum-cognitively inspired models are introduced and discussed in detail, focusing on how they approach the key challenges of the sentiment analysis task. Finally, we discuss the limitations of the current research and highlight future research directions
Fuzzy Natural Logic in IFSA-EUSFLAT 2021
The present book contains five papers accepted and published in the Special Issue, âFuzzy Natural Logic in IFSA-EUSFLAT 2021â, of the journal Mathematics (MDPI). These papers are extended versions of the contributions presented in the conference âThe 19th World Congress of the International Fuzzy Systems Association and the 12th Conference of the European Society for Fuzzy Logic and Technology jointly with the AGOP, IJCRS, and FQAS conferencesâ, which took place in Bratislava (Slovakia) from September 19 to September 24, 2021. Fuzzy Natural Logic (FNL) is a system of mathematical fuzzy logic theories that enables us to model natural language terms and rules while accounting for their inherent vagueness and allows us to reason and argue using the tools developed in them. FNL includes, among others, the theory of evaluative linguistic expressions (e.g., small, very large, etc.), the theory of fuzzy and intermediate quantifiers (e.g., most, few, many, etc.), and the theory of fuzzy/linguistic IFâTHEN rules and logical inference. The papers in this Special Issue use the various aspects and concepts of FNL mentioned above and apply them to a wide range of problems both theoretically and practically oriented. This book will be of interest for researchers working in the areas of fuzzy logic, applied linguistics, generalized quantifiers, and their applications
Tradition and Innovation in Construction Project Management
This book is a reprint of the Special Issue 'Tradition and Innovation in Construction Project Management' that was published in the journal Buildings
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