Multiobjective Tactical Planning under Uncertainty for Air Traffic Flow and Capacity Management

We investigate a method to deal with congestion of sectors and delays in the tactical phase of air traffic flow and capacity management. It relies on temporal objectives given for every point of the flight plans and shared among the controllers in order to create a collaborative environment. This would enhance the transition from the network view of the flow management to the local view of air traffic control. Uncertainty is modeled at the trajectory level with temporal information on the boundary points of the crossed sectors and then, we infer the probabilistic occupancy count. Therefore, we can model the accuracy of the trajectory prediction in the optimization process in order to fix some safety margins. On the one hand, more accurate is our prediction; more efficient will be the proposed solutions, because of the tighter safety margins. On the other hand, when uncertainty is not negligible, the proposed solutions will be more robust to disruptions. Furthermore, a multiobjective algorithm is used to find the tradeoff between the delays and congestion, which are antagonist in airspace with high traffic density. The flow management position can choose manually, or automatically with a preference-based algorithm, the adequate solution. This method is tested against two instances, one with 10 flights and 5 sectors and one with 300 flights and 16 sectors.Comment: IEEE Congress on Evolutionary Computation (2013). arXiv admin note: substantial text overlap with arXiv:1309.391

Controller design for synchronization of an array of delayed neural networks using a controllable

This is the post-print version of the Article - Copyright @ 2011 ElsevierIn this paper, a controllable probabilistic particle swarm optimization (CPPSO) algorithm is introduced based on Bernoulli stochastic variables and a competitive penalized method. The CPPSO algorithm is proposed to solve optimization problems and is then applied to design the memoryless feedback controller, which is used in the synchronization of an array of delayed neural networks (DNNs). The learning strategies occur in a random way governed by Bernoulli stochastic variables. The expectations of Bernoulli stochastic variables are automatically updated by the search environment. The proposed method not only keeps the diversity of the swarm, but also maintains the rapid convergence of the CPPSO algorithm according to the competitive penalized mechanism. In addition, the convergence rate is improved because the inertia weight of each particle is automatically computed according to the feedback of fitness value. The efficiency of the proposed CPPSO algorithm is demonstrated by comparing it with some well-known PSO algorithms on benchmark test functions with and without rotations. In the end, the proposed CPPSO algorithm is used to design the controller for the synchronization of an array of continuous-time delayed neural networks.This research was partially supported by the National Natural Science Foundation of PR China (Grant No 60874113), the Research Fund for the Doctoral Program of Higher Education (Grant No 200802550007), the Key Creative Project of Shanghai Education Community (Grant No 09ZZ66), the Key Foundation Project of Shanghai(Grant No 09JC1400700), the Engineering and Physical Sciences Research Council EPSRC of the U.K. under Grant No. GR/S27658/01, an International Joint Project sponsored by the Royal Society of the U.K., and the Alexander von Humboldt Foundation of Germany

Learning mutational graphs of individual tumour evolution from single-cell and multi-region sequencing data

Background. A large number of algorithms is being developed to reconstruct evolutionary models of individual tumours from genome sequencing data. Most methods can analyze multiple samples collected either through bulk multi-region sequencing experiments or the sequencing of individual cancer cells. However, rarely the same method can support both data types. Results. We introduce TRaIT, a computational framework to infer mutational graphs that model the accumulation of multiple types of somatic alterations driving tumour evolution. Compared to other tools, TRaIT supports multi-region and single-cell sequencing data within the same statistical framework, and delivers expressive models that capture many complex evolutionary phenomena. TRaIT improves accuracy, robustness to data-specific errors and computational complexity compared to competing methods. Conclusions. We show that the application of TRaIT to single-cell and multi-region cancer datasets can produce accurate and reliable models of single-tumour evolution, quantify the extent of intra-tumour heterogeneity and generate new testable experimental hypotheses