On optimal designs for clinical trials: An updated review

Optimization of clinical trial designs can help investigators achieve higher qualityresults for the given resource constraints. The present paper gives an overviewof optimal designs for various important problems that arise in different stages ofclinical drug development, including phase I dose–toxicity studies; phase I/II studiesthat consider early efficacy and toxicity outcomes simultaneously; phase IIdose–response studies driven by multiple comparisons (MCP), modeling techniques(Mod), or their combination (MCP–Mod); phase III randomized controlled multiarmmulti-objective clinical trials to test difference among several treatment groups;and population pharmacokinetics–pharmacodynamics experiments. We find thatmodern literature is very rich with optimal design methodologies that can be utilizedby clinical researchers to improve efficiency of drug development

A state-of-the-art review on torque distribution strategies aimed at enhancing energy efficiency for fully electric vehicles with independently actuated drivetrains

© 2019, Levrotto and Bella. All rights reserved. Electric vehicles are the future of private passenger transportation. However, there are still several technological barriers that hinder the large scale adoption of electric vehicles. In particular, their limited autonomy motivates studies on methods for improving the energy efficiency of electric vehicles so as to make them more attractive to the market. This paper provides a concise review on the current state-of-the-art of torque distribution strategies aimed at enhancing energy efficiency for fully electric vehicles with independently actuated drivetrains (FEVIADs). Starting from the operating principles, which include the "control allocation" problem, the peculiarities of each proposed solution are illustrated. All the existing techniques are categorized based on a selection of parameters deemed relevant to provide a comprehensive overview and understanding of the topic. Finally, future concerns and research perspectives for FEVIAD are discussed

Estimation of pulse heights and arrival times

The problem is studied of estimating the arrival times and heights of pulses of known shape observed with white additive noise. The main difficulty is estimating the number of pulses. When a maximum likelihood formulation is employed for the estimation problem, difficulties similar to the problem of estimating the order of an unknown system arise. The problem may be overcome using Rissanen's shortest data description approach. An estimation algorithm is described, and its consistency is proved. The results are illustrated by a simulation study using an example from seismic data processing also studied by Mendel