UNRAVELLING DIABETIC RETINOPATHY THROUGH IMAGE PROCESSING, NEURAL NETWORKS AND FUZZY LOGIC – A REVIEW

One of the main causes of blindness is diabetic retinopathy (DR) and it may affect people of any ages. In these days, both young and old ages are affected by diabetes, and the di abetes is the main cause of DR. Hence, it is necessary to have an automated system with good accuracy and less computation time to diagnose and treat DR, and the automated system can simplify the work of ophthalmologists. The objective is to present an overview of various works recently in detecting and segmenting the various lesions of DR. Papers were categorized based on the diagnosing tools and the methods used for detecting early and advanced stage lesions. The early lesions of DR are microaneurysms, hemorrhages, exudates, and cotton wool spots and in the advanced stage, new and fragile blood vessels can be grown. Results have been evaluated in terms of sensitivity, specificity, accuracy and receiver operating characteristic curve. This paper analyzed the various steps and different algorithms used recently for the detection and classification of DR lesions. A comparison of performances has been made in terms of sensitivity, specificity, area under the curve, and accuracy. Suggestions, future workand the area to be improved were also discussed.Keywords: Diabetic retinopathy, Image processing, Morphological operations, Neural network, Fuzzy logic.Â

CAD system for early diagnosis of diabetic retinopathy based on 3D extracted imaging markers.

This dissertation makes significant contributions to the field of ophthalmology, addressing the segmentation of retinal layers and the diagnosis of diabetic retinopathy (DR). The first contribution is a novel 3D segmentation approach that leverages the patientspecific anatomy of retinal layers. This approach demonstrates superior accuracy in segmenting all retinal layers from a 3D retinal image compared to current state-of-the-art methods. It also offers enhanced speed, enabling potential clinical applications. The proposed segmentation approach holds great potential for supporting surgical planning and guidance in retinal procedures such as retinal detachment repair or macular hole closure. Surgeons can benefit from the accurate delineation of retinal layers, enabling better understanding of the anatomical structure and more effective surgical interventions. Moreover, real-time guidance systems can be developed to assist surgeons during procedures, improving overall patient outcomes. The second contribution of this dissertation is the introduction of a novel computeraided diagnosis (CAD) system for precise identification of diabetic retinopathy. The CAD system utilizes 3D-OCT imaging and employs an innovative approach that extracts two distinct features: first-order reflectivity and 3D thickness. These features are then fused and used to train and test a neural network classifier. The proposed CAD system exhibits promising results, surpassing other machine learning and deep learning algorithms commonly employed in DR detection. This demonstrates the effectiveness of the comprehensive analysis approach employed by the CAD system, which considers both low-level and high-level data from the 3D retinal layers. The CAD system presents a groundbreaking contribution to the field, as it goes beyond conventional methods, optimizing backpropagated neural networks to integrate multiple levels of information effectively. By achieving superior performance, the proposed CAD system showcases its potential in accurately diagnosing DR and aiding in the prevention of vision loss. In conclusion, this dissertation presents novel approaches for the segmentation of retinal layers and the diagnosis of diabetic retinopathy. The proposed methods exhibit significant improvements in accuracy, speed, and performance compared to existing techniques, opening new avenues for clinical applications and advancements in the field of ophthalmology. By addressing future research directions, such as testing on larger datasets, exploring alternative algorithms, and incorporating user feedback, the proposed methods can be further refined and developed into robust, accurate, and clinically valuable tools for diagnosing and monitoring retinal diseases

Classification of Diabetic Retinopathy by Deep Learning

Diabetic retinopathy (DR), which is a leading cause of adult blindness, primarily affects individuals with diabetes. The manual diagnosis of DR, with the assistance of an ophthalmologist, has proven to be a time-consuming and challenging process. Late detection of DR is a significant factor contributing to the progression of the disease. To address this issue, the present study utilizes deep learning (DL) and transfer learning algorithms to analyze different stages of DR and precisely detect the condition. Using a large dataset comprising approximately 60,000 images, this study employs ResNet-101, DenseNet121, InceptionResNetV2, and EfficientNetB0 DL models to automatically assess the progression of DR. Images of patients’ eyes are inputted into the models, and the DL architectures are adapted to extract relevant features from the eye images. The study’s findings demonstrate that DenseNet121 outperforms ResNet-101, InceptionResNetV2, and EfficientNetB0 in accurately classifying the five stages of DR. The accuracy of the models was 97%, 96%, 95%, and 94%, respectively. These results underscore the effectiveness of DL in achieving an accurate and comprehensive classification of retinitis pigmentosa. By enabling accurate and timely diagnosis of DR, the application of DL techniques significantly contributes to the field of ophthalmology, facilitating improved treatment decisions for patients

Cross Modality Feature Fusion Framework for Diabetic Retinopathy Image Classification

Diabetic retinopathy (DR) is a prevalent ocular condition and a prominent contributor to vision impairment in individuals with diabetes. Consistent monitoring through fundus photography and prompt intervention represents the most efficient strategy for controlling this ailment. Given the substantial diabetic patient population and their extensive screening needs, there is a growing inclination towards harnessing computer-aided and entirely automated methods for diagnosing DR. Over the past years, deep neural networks have achieved remarkable progress across a wide range of applications. Consequently, automating the diagnosis of DR and delivering tailored recommendations to DR patients underscores the significance of accurate and intricate DR classification. In this work, we have present a cross modality feature fusion based framework for diabetic retinopathy (DR) image classification. Here, cross modality means RGB image and it’s green channel. Initially, we have present multi-scale multi- receptive feature extraction block to learn the local and global features from both the modalities. Further, the learned features at various scale are fused effectively with present multi-level feature fusion block for image classification task. We evaluated our present framework on MESSIDOR and IDRID database by comparing it to state-of-the-art (SOTA) deep learning frame- works for DR image classification. The result analysis clearly demonstrate that the present cross-modality feature fusion based classification framework outperforms existing SOTA frameworks in terms of various evaluation parameters

Image Processing and Deep Learning Integration for Enhancing Diabetic Retinopathy Diagnosis through Advanced Telemedicine

Accurate and timely diagnosis of diabetic retinopathy is pivotal for preventing vision loss and enabling effective treatment. This paper presents a pivotal evaluation of an innovative telemedicine system designed for diabetic retinopathy diagnosis. The system combines image processing and deep learning techniques to automate the assessment of retinal fundus images, with a focus on utilizing Convolutional Neural Networks (CNNs) and advanced image processing algorithms. In this study, we rigorously evaluate the accuracy and effectiveness of this telemedicine system using a diverse dataset of retinal images. Our findings demonstrate the system's remarkable ability to identify diabetic retinopathy accurately. These results shed light on the potential of this integrated approach for real-world clinical applications. The synergy of image processing and deep learning presents a promising solution for automated and timely diabetic retinopathy diagnosis, ultimately enhancing patient care and improving outcomes

Automated Diagnosis and Grading of Diabetic Retinopathy Using Optical Coherence Tomography

Purpose: We determine the feasibility and accuracy of a computer-assisted diagnostic (CAD) system to diagnose and grade nonproliferative diabetic retinopathy (NPDR) from optical coherence tomography (OCT) images. Methods: A cross-sectional, single-center study was done of type II diabetics who presented for routine screening and/or monitoring exams. Inclusion criteria were age 18 or older, diagnosis of diabetes mellitus type II, and clear media allowing for OCT imaging. Exclusion criteria were inability to image the macula, posterior staphylomas, proliferative diabetic retinopathy, and concurrent retinovascular disease. All patients underwent a full dilated eye exam and spectral-domain OCT of a 6 x 6 mm area of the macula in both eyes. These images then were analyzed by a novel CAD system that segments the retina into 12 layers; quantifies the reflectivity, curvature, and thickness of each layer; and ultimately uses this information to train a neural network that classifies images as either normal or having NPDR, and then further grades the level of retinopathy. A first dataset was tested by leave-one-subject-out (LOSO) methods and by 2- and 4-fold cross-validation. The system then was tested on a second, independent dataset. Results: Using LOSO experiments on a dataset of images from 80 patients, the proposed CAD system distinguished normal from NPDR subjects with 93.8% accuracy (sensitivity = 92.5%, specificity = 95%) and achieved 97.4% correct classification between subclinical and mild/moderate DR. When tested on an independent dataset of 40 patients, the proposed system distinguished between normal and NPDR subjects with 92.5% accuracy and between subclinical and mild/moderate NPDR with 95% accuracy. Conclusions: A CAD system for automated diagnosis of NPDR based on macular OCT images from type II diabetics is feasible, reliable, and accurate

Leveraging Semi-Supervised Graph Learning for Enhanced Diabetic Retinopathy Detection

Diabetic Retinopathy (DR) is a significant cause of blindness globally, highlighting the urgent need for early detection and effective treatment. Recent advancements in Machine Learning (ML) techniques have shown promise in DR detection, but the availability of labeled data often limits their performance. This research proposes a novel Semi-Supervised Graph Learning SSGL algorithm tailored for DR detection, which capitalizes on the relationships between labelled and unlabeled data to enhance accuracy. The work begins by investigating data augmentation and preprocessing techniques to address the challenges of image quality and feature variations. Techniques such as image cropping, resizing, contrast adjustment, normalization, and data augmentation are explored to optimize feature extraction and improve the overall quality of retinal images. Moreover, apart from detection and diagnosis, this work delves into applying ML algorithms for predicting the risk of developing DR or the likelihood of disease progression. Personalized risk scores for individual patients are generated using comprehensive patient data encompassing demographic information, medical history, and retinal images. The proposed Semi-Supervised Graph learning algorithm is rigorously evaluated on two publicly available datasets and is benchmarked against existing methods. Results indicate significant improvements in classification accuracy, specificity, and sensitivity while demonstrating robustness against noise and outlie rs.Notably, the proposed algorithm addresses the challenge of imbalanced datasets, common in medical image analysis, further enhancing its practical applicability.Comment: 13 pages, 6 figure