2,823 research outputs found
Neuromodulatory effects on early visual signal processing
Understanding how the brain processes information and generates simple to complex behavior constitutes one of the core objectives in systems neuroscience. However, when studying different neural circuits, their dynamics and interactions researchers often assume fixed connectivity, overlooking a crucial factor - the effect of neuromodulators. Neuromodulators can modulate circuit activity depending on several aspects, such as different brain states or sensory contexts. Therefore, considering the modulatory effects of neuromodulators on the functionality of neural circuits is an indispensable step towards a more complete picture of the brain’s ability to process information. Generally, this issue affects all neural systems; hence this thesis tries to address this with an experimental and computational approach to resolve neuromodulatory effects on cell type-level in a well-define system, the mouse retina. In the first study, we established and applied a machine-learning-based classification algorithm to identify individual functional retinal ganglion cell types, which enabled detailed cell type-resolved analyses. We applied the classifier to newly acquired data of light-evoked retinal ganglion cell responses and successfully identified their functional types. Here, the cell type-resolved analysis revealed that a particular principle of efficient coding applies to all types in a similar way. In a second study, we focused on the issue of inter-experimental variability that can occur during the process of pooling datasets. As a result, further downstream analyses may be complicated by the subtle variations between the individual datasets. To tackle this, we proposed a theoretical framework based on an adversarial autoencoder with the objective to remove inter-experimental variability from the pooled dataset, while preserving the underlying biological signal of interest. In the last study of this thesis, we investigated the functional effects of the neuromodulator nitric oxide on the retinal output signal. To this end, we used our previously developed retinal ganglion cell type classifier to unravel type-specific effects and established a paired recording protocol to account for type-specific time-dependent effects. We found that certain
retinal ganglion cell types showed adaptational type-specific changes and that nitric oxide had a distinct modulation of a particular group of retinal ganglion cells.
In summary, I first present several experimental and computational methods that allow to
study functional neuromodulatory effects on the retinal output signal in a cell type-resolved manner and, second, use these tools to demonstrate their feasibility to study the neuromodulator nitric oxide
Analytical validation of innovative magneto-inertial outcomes: a controlled environment study.
peer reviewe
Comparing the production of a formula with the development of L2 competence
This pilot study investigates the production of a formula with the development of L2 competence over proficiency levels of a spoken learner corpus. The results show that the formula
in beginner production data is likely being recalled holistically from learners’ phonological
memory rather than generated online, identifiable by virtue of its fluent production in absence
of any other surface structure evidence of the formula’s syntactic properties. As learners’ L2
competence increases, the formula becomes sensitive to modifications which show structural
conformity at each proficiency level. The transparency between the formula’s modification
and learners’ corresponding L2 surface structure realisations suggest that it is the independent
development of L2 competence which integrates the formula into compositional language,
and ultimately drives the SLA process forward
30th European Congress on Obesity (ECO 2023)
This is the abstract book of 30th European Congress on Obesity (ECO 2023
A survey on reconfigurable intelligent surfaces: wireless communication perspective
Using reconfigurable intelligent surfaces (RISs) to improve the coverage and the data rate of future wireless networks is a viable option. These surfaces are constituted of a significant number of passive and nearly passive components that interact with incident signals in a smart way, such as by reflecting them, to increase the wireless system's performance as a result of which the notion of a smart radio environment comes to fruition. In this survey, a study review of RIS-assisted wireless communication is supplied starting with the principles of RIS which include the hardware architecture, the control mechanisms, and the discussions of previously held views about the channel model and pathloss; then the performance analysis considering different performance parameters, analytical approaches and metrics are presented to describe the RIS-assisted wireless network performance improvements. Despite its enormous promise, RIS confronts new hurdles in integrating into wireless networks efficiently due to its passive nature. Consequently, the channel estimation for, both full and nearly passive RIS and the RIS deployments are compared under various wireless communication models and for single and multi-users. Lastly, the challenges and potential future study areas for the RIS aided wireless communication systems are proposed
Split Federated Learning for 6G Enabled-Networks: Requirements, Challenges and Future Directions
Sixth-generation (6G) networks anticipate intelligently supporting a wide
range of smart services and innovative applications. Such a context urges a
heavy usage of Machine Learning (ML) techniques, particularly Deep Learning
(DL), to foster innovation and ease the deployment of intelligent network
functions/operations, which are able to fulfill the various requirements of the
envisioned 6G services. Specifically, collaborative ML/DL consists of deploying
a set of distributed agents that collaboratively train learning models without
sharing their data, thus improving data privacy and reducing the
time/communication overhead. This work provides a comprehensive study on how
collaborative learning can be effectively deployed over 6G wireless networks.
In particular, our study focuses on Split Federated Learning (SFL), a technique
recently emerged promising better performance compared with existing
collaborative learning approaches. We first provide an overview of three
emerging collaborative learning paradigms, including federated learning, split
learning, and split federated learning, as well as of 6G networks along with
their main vision and timeline of key developments. We then highlight the need
for split federated learning towards the upcoming 6G networks in every aspect,
including 6G technologies (e.g., intelligent physical layer, intelligent edge
computing, zero-touch network management, intelligent resource management) and
6G use cases (e.g., smart grid 2.0, Industry 5.0, connected and autonomous
systems). Furthermore, we review existing datasets along with frameworks that
can help in implementing SFL for 6G networks. We finally identify key technical
challenges, open issues, and future research directions related to SFL-enabled
6G networks
Modern meat: the next generation of meat from cells
Modern Meat is the first textbook on cultivated meat, with contributions from over 100 experts within the cultivated meat community.
The Sections of Modern Meat comprise 5 broad categories of cultivated meat: Context, Impact, Science, Society, and World.
The 19 chapters of Modern Meat, spread across these 5 sections, provide detailed entries on cultivated meat. They extensively tour a range of topics including the impact of cultivated meat on humans and animals, the bioprocess of cultivated meat production, how cultivated meat may become a food option in Space and on Mars, and how cultivated meat may impact the economy, culture, and tradition of Asia
Backcasting for transformative water management
This thesis reports on a study on the use of backcasting for climate adaptation in water management. It offers new insights and recommendations for the further development of backcasting approaches for transformative climate adaptation
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