907 research outputs found
A Statistical Model for Simultaneous Template Estimation, Bias Correction, and Registration of 3D Brain Images
Template estimation plays a crucial role in computational anatomy since it
provides reference frames for performing statistical analysis of the underlying
anatomical population variability. While building models for template
estimation, variability in sites and image acquisition protocols need to be
accounted for. To account for such variability, we propose a generative
template estimation model that makes simultaneous inference of both bias fields
in individual images, deformations for image registration, and variance
hyperparameters. In contrast, existing maximum a posterori based methods need
to rely on either bias-invariant similarity measures or robust image
normalization. Results on synthetic and real brain MRI images demonstrate the
capability of the model to capture heterogeneity in intensities and provide a
reliable template estimation from registration
Visibility Constrained Generative Model for Depth-based 3D Facial Pose Tracking
In this paper, we propose a generative framework that unifies depth-based 3D
facial pose tracking and face model adaptation on-the-fly, in the unconstrained
scenarios with heavy occlusions and arbitrary facial expression variations.
Specifically, we introduce a statistical 3D morphable model that flexibly
describes the distribution of points on the surface of the face model, with an
efficient switchable online adaptation that gradually captures the identity of
the tracked subject and rapidly constructs a suitable face model when the
subject changes. Moreover, unlike prior art that employed ICP-based facial pose
estimation, to improve robustness to occlusions, we propose a ray visibility
constraint that regularizes the pose based on the face model's visibility with
respect to the input point cloud. Ablation studies and experimental results on
Biwi and ICT-3DHP datasets demonstrate that the proposed framework is effective
and outperforms completing state-of-the-art depth-based methods
Uncertainty quantification in non-rigid image registration via stochastic gradient Markov chain Monte Carlo
We develop a new Bayesian model for non-rigid registration of three-dimensional medical images, with a focus on uncertainty quantification. Probabilistic registration of large images with calibrated uncertainty estimates is difficult for both computational and modelling reasons. To address the computational issues, we explore connections between the Markov chain Monte Carlo by backpropagation and the variational inference by backpropagation frameworks, in order to efficiently draw samples from the posterior distribution of transformation parameters. To address the modelling issues, we formulate a Bayesian model for image registration that overcomes the existing barriers when using a dense, high-dimensional, and diffeomorphic transformation parametrisation. This results in improved calibration of uncertainty estimates. We compare the model in terms of both image registration accuracy and uncertainty quantification to VoxelMorph, a state-of-the-art image registration model based on deep learning
Keyframe-based monocular SLAM: design, survey, and future directions
Extensive research in the field of monocular SLAM for the past fifteen years
has yielded workable systems that found their way into various applications in
robotics and augmented reality. Although filter-based monocular SLAM systems
were common at some time, the more efficient keyframe-based solutions are
becoming the de facto methodology for building a monocular SLAM system. The
objective of this paper is threefold: first, the paper serves as a guideline
for people seeking to design their own monocular SLAM according to specific
environmental constraints. Second, it presents a survey that covers the various
keyframe-based monocular SLAM systems in the literature, detailing the
components of their implementation, and critically assessing the specific
strategies made in each proposed solution. Third, the paper provides insight
into the direction of future research in this field, to address the major
limitations still facing monocular SLAM; namely, in the issues of illumination
changes, initialization, highly dynamic motion, poorly textured scenes,
repetitive textures, map maintenance, and failure recovery
Doctor of Philosophy in Computing
dissertationAn important area of medical imaging research is studying anatomical diffeomorphic shape changes and detecting their relationship to disease processes. For example, neurodegenerative disorders change the shape of the brain, thus identifying differences between the healthy control subjects and patients affected by these diseases can help with understanding the disease processes. Previous research proposed a variety of mathematical approaches for statistical analysis of geometrical brain structure in three-dimensional (3D) medical imaging, including atlas building, brain variability quantification, regression, etc. The critical component in these statistical models is that the geometrical structure is represented by transformations rather than the actual image data. Despite the fact that such statistical models effectively provide a way for analyzing shape variation, none of them have a truly probabilistic interpretation. This dissertation contributes a novel Bayesian framework of statistical shape analysis for generic manifold data and its application to shape variability and brain magnetic resonance imaging (MRI). After we carefully define the distributions on manifolds, we then build Bayesian models for analyzing the intrinsic variability of manifold data, involving the mean point, principal modes, and parameter estimation. Because there is no closed-form solution for Bayesian inference of these models on manifolds, we develop a Markov Chain Monte Carlo method to sample the hidden variables from the distribution. The main advantages of these Bayesian approaches are that they provide parameter estimation and automatic dimensionality reduction for analyzing generic manifold-valued data, such as diffeomorphisms. Modeling the mean point of a group of images in a Bayesian manner allows for learning the regularity parameter from data directly rather than having to set it manually, which eliminates the effort of cross validation for parameter selection. In population studies, our Bayesian model of principal modes analysis (1) automatically extracts a low-dimensional, second-order statistics of manifold data variability and (2) gives a better geometric data fit than nonprobabilistic models. To make this Bayesian framework computationally more efficient for high-dimensional diffeomorphisms, this dissertation presents an algorithm, FLASH (finite-dimensional Lie algebras for shooting), that hugely speeds up the diffeomorphic image registration. Instead of formulating diffeomorphisms in a continuous variational problem, Flash defines a completely new discrete reparameterization of diffeomorphisms in a low-dimensional bandlimited velocity space, which results in the Bayesian inference via sampling on the space of diffeomorphisms being more feasible in time. Our entire Bayesian framework in this dissertation is used for statistical analysis of shape data and brain MRIs. It has the potential to improve hypothesis testing, classification, and mixture models
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