Ontology-based knowledge representation of experiment metadata in biological data mining

According to the PubMed resource from the U.S. National Library of Medicine, over 750,000 scientific articles have been published in the ~5000 biomedical journals worldwide in the year 2007 alone. The vast majority of these publications include results from hypothesis-driven experimentation in overlapping biomedical research domains. Unfortunately, the sheer volume of information being generated by the biomedical research enterprise has made it virtually impossible for investigators to stay aware of the latest findings in their domain of interest, let alone to be able to assimilate and mine data from related investigations for purposes of meta-analysis. While computers have the potential for assisting investigators in the extraction, management and analysis of these data, information contained in the traditional journal publication is still largely unstructured, free-text descriptions of study design, experimental application and results interpretation, making it difficult for computers to gain access to the content of what is being conveyed without significant manual intervention. In order to circumvent these roadblocks and make the most of the output from the biomedical research enterprise, a variety of related standards in knowledge representation are being developed, proposed and adopted in the biomedical community. In this chapter, we will explore the current status of efforts to develop minimum information standards for the representation of a biomedical experiment, ontologies composed of shared vocabularies assembled into subsumption hierarchical structures, and extensible relational data models that link the information components together in a machine-readable and human-useable framework for data mining purposes

Ontology technology for the development and deployment of learning technology systems - a survey

The World-Wide Web is undergoing dramatic changes at the moment. The Semantic Web is an initiative to bring meaning to the Web. The Semantic Web is based on ontology technology – a knowledge representation framework – at its core. We illustrate the importance of this evolutionary development. We survey five scenarios demonstrating different forms of applications of ontology technologies in the development and deployment of learning technology systems. Ontology technologies are highly useful to organise, personalise, and publish learning content and to discover, generate, and compose learning objects

Semantic Description, Publication and Discovery of Workflows in myGrid

The bioinformatics scientific process relies on in silico experiments, which are experiments executed in full in a computational environment. Scientists wish to encode the designs of these experiments as workflows because they provide minimal, declarative descriptions of the designs, overcoming many barriers to the sharing and re-use of these designs between scientists and enable the use of the most appropriate services available at any one time. We anticipate that the number of workflows will increase quickly as more scientists begin to make use of existing workflow construction tools to express their experiment designs. Discovery then becomes an increasingly hard problem, as it becomes more difficult for a scientist to identify the workflows relevant to their particular research goals amongst all those on offer. While many approaches exist for the publishing and discovery of services, there have been few attempts to address where and how authors of experimental designs should advertise the availability of their work or how relevant workflows can be discovered with minimal effort from the user. As the users designing and adapting experiments will not necessarily have a computer science background, we also have to consider how publishing and discovery can be achieved in such a way that they are not required to have detailed technical knowledge of workflow scripting languages. Furthermore, we believe they should be able to make use of others' expert knowledge (the semantics) of the given scientific domain. In this paper, we define the issues related to the semantic description, publishing and discovery of workflows, and demonstrate how the architecture created by the myGrid project aids scientists in this process. We give a walk-through of how users can construct, publish, annotate, discover and enact workflows via the user interfaces of the myGrid architecture; we then describe novel middleware protocols, making use of the Semantic Web technologies RDF and OWL to support workflow publishing and discovery

Conceptual Linking: Ontology-based Open Hypermedia

This paper describes the attempts of the COHSE project to define and deploy a Conceptual Open Hypermedia Service. Consisting of • an ontological reasoning service which is used to represent a sophisticated conceptual model of document terms and their relationships; • a Web-based open hypermedia link service that can offer a range of different link-providing facilities in a scalable and non-intrusive fashion; and integrated to form a conceptual hypermedia system to enable documents to be linked via metadata describing their contents and hence to improve the consistency and breadth of linking of WWW documents at retrieval time (as readers browse the documents) and authoring time (as authors create the documents)

Conceptual Linking: Ontology-based Open Hypermedia

This paper describes the attempts of the COHSE project to define and deploy a Conceptual Open Hypermedia Service. Consisting of • an ontological reasoning service which is used to represent a sophisticated conceptual model of document terms and their relationships; • a Web-based open hypermedia link service that can offer a range of different link-providing facilities in a scalable and non-intrusive fashion; and integrated to form a conceptual hypermedia system to enable documents to be linked via metadata describing their contents and hence to improve the consistency and breadth of linking of WWW documents at retrieval time (as readers browse the documents) and authoring time (as authors create the documents)