Using machine learning on the sources of retinal images for diagnosis by proxy of diabetes mellitus and diabetic retinopathy

In current research in ophthalmology, images of the vascular system in the human retina are used as exploratory proxies for pathologies affecting different organs. This thesis addresses the analysis, using machine learning and computer vision techniques, of retinal images acquired with different techniques (Fundus retinographies, optical coherence tomography and optical coherence tomography angiography), with the objective of using them to assist diagnostic decision making in diabetes mellitus and diabetic retinopathy. This thesis explores the use of matrix factorization-based source extraction techniques, as the basis to transform the retinal images for classification. The proposed approach consists on preprocessing the images to enable the learning of an unsupervised parts-based representation prior to the classification. As a result of the use of interpretable models, with this approach we unveiled an important bias in the data. After correcting for the bias, promising results were still obtained which merit for further exploration

Unsupervised Sparse Dirichlet-Net for Hyperspectral Image Super-Resolution

In many computer vision applications, obtaining images of high resolution in both the spatial and spectral domains are equally important. However, due to hardware limitations, one can only expect to acquire images of high resolution in either the spatial or spectral domains. This paper focuses on hyperspectral image super-resolution (HSI-SR), where a hyperspectral image (HSI) with low spatial resolution (LR) but high spectral resolution is fused with a multispectral image (MSI) with high spatial resolution (HR) but low spectral resolution to obtain HR HSI. Existing deep learning-based solutions are all supervised that would need a large training set and the availability of HR HSI, which is unrealistic. Here, we make the first attempt to solving the HSI-SR problem using an unsupervised encoder-decoder architecture that carries the following uniquenesses. First, it is composed of two encoder-decoder networks, coupled through a shared decoder, in order to preserve the rich spectral information from the HSI network. Second, the network encourages the representations from both modalities to follow a sparse Dirichlet distribution which naturally incorporates the two physical constraints of HSI and MSI. Third, the angular difference between representations are minimized in order to reduce the spectral distortion. We refer to the proposed architecture as unsupervised Sparse Dirichlet-Net, or uSDN. Extensive experimental results demonstrate the superior performance of uSDN as compared to the state-of-the-art.Comment: Accepted by The IEEE Conference on Computer Vision and Pattern Recognition (CVPR 2018, Spotlight

New Approaches in Multi-View Clustering

Many real-world datasets can be naturally described by multiple views. Due to this, multi-view learning has drawn much attention from both academia and industry. Compared to single-view learning, multi-view learning has demonstrated plenty of advantages. Clustering has long been serving as a critical technique in data mining and machine learning. Recently, multi-view clustering has achieved great success in various applications. To provide a comprehensive review of the typical multi-view clustering methods and their corresponding recent developments, this chapter summarizes five kinds of popular clustering methods and their multi-view learning versions, which include k-means, spectral clustering, matrix factorization, tensor decomposition, and deep learning. These clustering methods are the most widely employed algorithms for single-view data, and lots of efforts have been devoted to extending them for multi-view clustering. Besides, many other multi-view clustering methods can be unified into the frameworks of these five methods. To promote further research and development of multi-view clustering, some popular and open datasets are summarized in two categories. Furthermore, several open issues that deserve more exploration are pointed out in the end