Radiographic and Ultrasonographic Findings in Three Surgically Confirmed Cases of Small Intestinal Ischemia Related to Mesenteric Volvulus or Intestinal Torsion in Dogs

This case report describes the radiographic and ultrasonographic findings of three surgically confirmed cases of mesenteric volvulus or intestinal torsion in dogs. In all three cases, ultrasonographic findings included segmental ileus and absent or markedly reduced peristalsis of the affected small intestine, and partial loss of wall layering with increased overall echogenicity of the intestinal wall, but with normal to mildly increased wall thickening. No blood flow was detected in the affected small intestinal wall when assessed with colour Doppler. A moderate amount of peritoneal effusion was also detected with hyperechoic omental and mesenteric fat tissue throughout the peritoneal cavity. Few reports describe ultrasonographic findings of small intestinal ischemia in small animals. In all three cases presented here, ultrasound was helpful in demonstrating typical intestinal wall changes and helped to obtain the correct diagnosis of ischemic disease of the small intestine.Peer reviewe

Evaluation of integrin αvβ6 cystine knot PET tracers to detect cancer and idiopathic pulmonary fibrosis.

Advances in precision molecular imaging promise to transform our ability to detect, diagnose and treat disease. Here, we describe the engineering and validation of a new cystine knot peptide (knottin) that selectively recognizes human integrin αvβ6 with single-digit nanomolar affinity. We solve its 3D structure by NMR and x-ray crystallography and validate leads with 3 different radiolabels in pre-clinical models of cancer. We evaluate the lead tracer's safety, biodistribution and pharmacokinetics in healthy human volunteers, and show its ability to detect multiple cancers (pancreatic, cervical and lung) in patients at two study locations. Additionally, we demonstrate that the knottin PET tracers can also detect fibrotic lung disease in idiopathic pulmonary fibrosis patients. Our results indicate that these cystine knot PET tracers may have potential utility in multiple disease states that are associated with upregulation of integrin αvβ6

Gastric Dilation and Volvulus in the Dog

Acute gastric dilation in the canine is a primary condition which may be followed by gastric volvulus or even gastric rupture, When gastric volvulus occurs, it causes splenic rotation and often torsion of the splenic pedicle. The gastric dilation-volvulus (GDV) syndrome which must always be considered a true emergency

Patterns of injury and violence in Yaoundé Cameroon: an analysis of hospital data.

BackgroundInjuries are quickly becoming a leading cause of death globally, disproportionately affecting sub-Saharan Africa, where reports on the epidemiology of injuries are extremely limited. Reports on the patterns and frequency of injuries are available from Cameroon are also scarce. This study explores the patterns of trauma seen at the emergency ward of the busiest trauma center in Cameroon's capital city.Materials and methodsAdministrative records from January 1, 2007, through December 31, 2007, were retrospectively reviewed; information on age, gender, mechanism of injury, and outcome was abstracted for all trauma patients presenting to the emergency ward. Univariate analysis was performed to assess patterns of injuries in terms of mechanism, date, age, and gender. Bivariate analysis was used to explore potential relationships between demographic variables and mechanism of injury.ResultsA total of 6,234 injured people were seen at the Central Hospital of Yaoundé's emergency ward during the year 2007. Males comprised 71% of those injured, and the mean age of injured patients was 29 years (SD = 14.9). Nearly 60% of the injuries were due to road traffic accidents, 46% of which involved a pedestrian. Intentional injuries were the second most common mechanism of injury (22.5%), 55% of which involved unarmed assault. Patients injured in falls were more likely to be admitted to the hospital (p < 0.001), whereas patients suffering intentional injuries and bites were less likely to be hospitalized (p < 0.001). Males were significantly more likely to be admitted than females (p < 0.001)DiscussionPatterns in terms of age, gender, and mechanism of injury are similar to reports from other countries from the same geographic region, but the magnitude of cases reported is high for a single institution in an African city the size of Yaoundé. As the burden of disease is predicted to increase dramatically in sub-Saharan Africa, immediate efforts in prevention and treatment in Cameroon are strongly warranted

Jefferson Medical College Alumni Bulletin–Vol. 2 No. 2; May, 1936

Table of contents – Vol. 2 No. 2; May, 1936 The Medical School and Research, page 1 Publications of the Faculty and Staff of Jefferson Medical College and Hospital 1931-1935 Inclusive, page 2 Jefferson Society Award, page 11 David M. Davis, B.S., M.D. Professor of Genito-Urinary Surgery, Jefferson Medical College, page 13 The Curtis Clinic, Its Relationship to the private and the referred patient, page 14 William Potter Memorial and Alpha Omega Alpha Lectures, page 16 Contributions of the Class of 1936 to the Alumni Fund, page 17 Alumni Fund, page 17 Library Collection of Old Diplomas, page 17 List of Jefferson Medical College Diplomas in the Library, page 17 J.Clarence Keeler 1871-1935, page 20 Thomas McCrae 1870-1935, page 20 DR. Charles E.G. Shannon, President of the Alumni Association 1936-1937, page 22 Branch Chapter Meetings of the Alumni Association, page 23 Class Reunion, page 24 Commencement Day Exercises and Speaker, page 24 Program of Commencement Season, page 25 Necrology list of the Alumni for the year 1935, page 26 Alumni Association of the Jefferson Medical College of Philadelphia, Officers for 1936-1937 page 2