Glycan analysis of the chicken synaptic plasma membrane glycoproteins - a major synaptic N-glycan carries the LewisX determinant

The majority of plasma membrane components are glycosylated. It is now widely accepted that this post-translational modification is crucial during the establishment, maintenance and function of the nervous system. Despite its significance, structural information about the glycosylation of nervous system specific glycoproteins is very limited. In the present study the major glycan structure of the chicken synaptic plasma membrane (SPM) associated glycoprotein glycans were determined. N-glycans were released by hydozinnolysis, labelled with 2-aminobenzam,ide, treated with neuraminidase and subsequently fractionated by size exclusion chromatography. Individual fractions were characterized by combination of high-pressure liquid chromatography, exoglicosidase treatment or reagent array analysis method (RAAM). In addition to oligomannose-type glycans, core-fucosylated complex glycans with biantennary bisecting glycans carrying the LewisX epitope were most abundant. The overall chicken glycan profile was strikingly similar to the rat brain glycan profile. The presence of the LewisX determinant in relatively large proportions suggests a tissue-specific function for these glycans

Analysis of the semileptonic (B_c -> B_u* l+ l-) decay from QCD sum rules

We analyze the semileptonic (B_c -> B_u* l+ l-) decay in the frame work of the Standard Model. We calculate the (B_c) to (B_u*) transition form factors in QCD sum rules. Analytical expressions for the spectral densities and gluon condensates are presented. The branching ratio of the (B_c -> B_u* l+ l-) decay is calculated, and it is obtained that this decay can be detectable at forthcoming LHC machines.Comment: 17 pages, no figures, LaTeX formatte

State of New York Public Employment Relations Board Decisions from April 25, 2002

4_25_2002_PERB_BD_DecisionsOCR.pdf: 382 downloads, before Oct. 1, 2020

Chandra detection of a parsec scale wind in the Broad Line Radio Galaxy 3C 382

We present unambiguous evidence for a parsec scale wind in the Broad-Line Radio Galaxy (BLRG) 3C 382, the first radio-loud AGN, with $R_{\rm L} = \log_{10}(f_{\rm 5GHz}/f_{4400})>1$, whereby an outflow has been measured with X-ray grating spectroscopy. A 118 ks Chandra grating (HETG) observation of 3C 382 has revealed the presence of several high ionization absorption lines in the soft X-ray band, from Fe, Ne, Mg and Si. The absorption lines are blue-shifted with respect to the systemic velocity of 3C 382 by -840\pm60 km/s and are resolved by Chandra with a velocity width of 340\pm70 km/s. The outflow appears to originate from a single zone of gas of column density $N_{\rm H} = 1.3 \times 10^{21}$ cm$^{-2}$ and ionization parameter $\log \xi = 2.45$. From the above measurements we calculate that the outflow is observed on parsec scales, within the likely range from 10-1000 pc, i.e., consistent with an origin in the Narrow Line Region.Comment: 11 pages, accepted for publication in Astrophysical Journal Letter

Effect of a mixture of caffeine and nicotinamide on the solubility of vitamin (B2) in aqueous solution

The effect of caffeine (CAF) and nicotinamide (NMD) on the solubility of a vitamin B2 derivative (FMN) has been evaluated for mixtures containing either a single hydrotrope (CAF or NMD) or the two hydrotropes simultaneously. A model for analysis of ternary systems, which takes into account all possible complexes between the molecules, has been developed and tested with experimental NMR data on the three-component mixture FMN–CAF–NMD. The results indicate that special attention should be given to the concentration of a hydrotropic agent used to enhance the solubility of a particular drug. A decrease in the efficacy of solubility of the vitamin on addition of large amounts of hydrotropic agent is expected in the two-component systems due to the increased proportion of self-association of the hydrotrope. It is found that a mixture of two hydrotropic agents leads to an increase in the solubility of the vitamin in three-component compared to the two-component system. Rather than using just one hydrotropic agent, it is proposed that a strategy for optimising the solubility of aromatic drugs is to use a mixture of hydrotropic agents

Bound-intersection detection for multiple-symbol differential unitary space-time modulation

This paper considers multiple-symbol differential detection (MSD) of differential unitary space-time modulation (DUSTM) over multiple-antenna systems. We derive a novel exact maximum-likelihood (ML) detector, called the bound-intersection detector (BID), using the extended Euclidean algorithm for single-symbol detection of diagonal constellations. While the ML search complexity is exponential in the number of transmit antennas and the data rate, our algorithm, particularly in high signal-to-noise ratio, achieves significant computational savings over the naive ML algorithm and the previous detector based on lattice reduction. We also develop four BID variants for MSD. The first two are ML and use branch-and-bound, the third one is suboptimal, which first uses BID to generate a candidate subset and then exhaustively searches over the reduced space, and the last one generalizes decision-feedback differential detection. Simulation results show that the BID and its MSD variants perform nearly ML, but do so with significantly reduced complexity

An Sp1 Modulated Regulatory Region Unique to Higher Primates Regulates Human Androgen Receptor Promoter Activity in Prostate Cancer Cells

Funding: This work was supported by the Chief Scientist’s Office (CSO) of the Scottish Government (http://www.cso.scot.nhs.uk/): CWH (CZB-4-477) and IH (ETM/382).Peer reviewedPublisher PD

Caravan Awnings: a Geometrical Problem

Two questions regardingthe design of caravan awnings were posed by a company.The company wishes to produce awnings with a pretty appearance. When an awning is attached to a caravan, some wrinkles could appear. We developed some methods to avoid the wrinkles. The problem is restricted to awnings which are made from one piece of cloth

Aphids (Hemiptera: Aphidoidea) associated with native trees in Malta (Central Mediterranean)

In the present study 25 aphid species which are known to be associated with trees in the Maltese Islands are recorded. Of these, 18 species represent new records; these include Aphis craccivora, Brachyunguis tamaricis, Cavariella aegopodii, Chaitophorus capreae, C. populialbae, Cinara cupressi, C. maghrebica, C. palaestinensis, Essigella californica, Eulachnus rileyi, E. tuberculostemmatus, Hoplocallis picta, Lachnus roboris, Myzocallis schreiberi, Tetraneura nigriabdominalis, Thelaxes suberi, Tinocallis takachihoensis and Tuberolachnus salignus. A number of the above mentioned species alternate hosts between the primary host, being the tree species, and secondary hosts being mainly roots of grasses. The record of Tetraneura ulmi could be incorrect and could possibly be referred to T. nigriabdominalis. Most of the aphid species recorded in the present study have restricted distribution in the Maltese Islands due to the rarity of their host trees. This is particularly so for those aphids associated with Populus, Quercus, Salix and Ulmus whose conservation should be addressed.peer-reviewe