Regulation of metabolism by miR-378

The present invention provides a method of regulating fatty acid metabolism in a cell by contacting the cell with a modulator of miR-378 and/or miR-378* activity or expression. The present invention also provides a method of treating or preventing a metabolic disorder, such as obesity, diabetes, or metabolic syndrome, in a subject by administering to the subject an inhibitor of miR-378 and/or miR-378* expression or activity. Methods of treating or preventing pathologic cardiac hypertrophy, cardiac remodeling, myocardial infarction, or heart failure in a subject by inhibiting the expression or activity of miR-378 and/or miR-378* in a subject are also disclosed.Board of Regents, University of Texas Syste

The running of the electromagnetic coupling alpha in small-angle Bhabha scattering

A method to determine the running of alpha from a measurement of small-angle Bhabha scattering is proposed and worked out. The method is suited to high statistics experiments at e+e- colliders, which are equipped with luminometers in the appropriate angular region. A new simulation code predicting small-angle Bhabha scattering is also presentedComment: 15 pages, 3 Postscript figure

Testimony of Herbert R. Northrup Before the Commission on the Future of Worker-Management Relations

Testimony_Northrup_090894.pdf: 378 downloads, before Oct. 1, 2020

The distribution of range sizes of native and alien plants in four European countries and the effects of residence time

Aim Do the statistical distributions of range sizes of native and alien species differ? If so, is this because of residence time effects? And can such effects indicate an average time to a maximum? Location Ireland, Britain, Germany and the Czech Republic. Methods The data are presence or absence of higher plants in mapping units of 100 km2 (Ireland and Britain) or c. 130 km2 (Germany and the Czech Republic) in areas varying from 79 to 357 thousand km2. Logit transforms of range sizes so defined were tested for normality, and examined by ANOVA, and by loess, ordinary least square (OLS) and reduced major axis regressions. Results Current range sizes, in logits, are near normally distributed. Those of native plants are larger than those of naturalized neophytes (plants introduced since 1500 ad) and much larger than those of casual neophytes. Archaeophytes (introduced earlier) have range sizes slightly larger than natives, except in Ireland. Residence time, the time since an invasive species arrived in the wild at a certain place, affects range sizes. The relationships of the range of naturalized neophytes to residence time are effectively straight in all four places, showing no significant curvature or asymptote back to 1500, though there are few records between 1500 and 1800. The relationships have an r2 of only about 10%. Both OLS regressions and reduced major axes can be used to estimate the time it takes for the range of a naturalized neophyte to reach a maximum. Main conclusions Established neophytes have smaller range size distributions than natives probably because many have not yet reached their maximum. We estimate it takes at least 150 years, possibly twice that, on average, for the maximum to be reached in areas of the order of 105 km2. Policy needs to allow for the variation in rates of spread and particularly the long time needed to fill ranges. Most naturalized neophytes are still expanding their ranges in Europe

The East Midlands in 2010: executive summary

The East Midlands in 2010 is the updated evidence base that supports the regional economic strategy, A Flourishing Region. It presents a statistical portrait of the region covering demography, housing, economy & productivity, the labour market, deprivation & economic inclusion, transport, infrastructure & development, the environment and the spatial structure of the economy along with a series of sub-regional profiles. This document is the executive summary

ICT utilization and the information economy: the case of Malaysia

Malaysia is taking steps to transform the economy from being production-based to being knowledge driven (K-economy). In line with this objective, information and communication technologies (ICT) have been identified as the strategic enabling tools that will support the growth of the Malaysian economy as well as enhance the living standard of the population. Hence, in the past decade various initiatives have been taken by the government to promote the use and development of ICT. However, there are many issues and challenges that need to be addressed by the country before a successful transformation to a K-economy can be made. One of the issues is ICT utilization for the development of an information society and economy in the country. The paper assesses the current state of ICT utilization in Malaysia based on secondary data. The result indicates that the level of ICT utilization in the country is still low compared to selected countries and there exist wide disparities among states in Malaysia in terms of accessibility to ICT

Joint data detection and channel estimation for OFDM systems

We develop new blind and semi-blind data detectors and channel estimators for orthogonal frequency-division multiplexing (OFDM) systems. Our data detectors require minimizing a complex, integer quadratic form in the data vector. The semi-blind detector uses both channel correlation and noise variance. The quadratic for the blind detector suffers from rank deficiency; for this, we give a low-complexity solution. Avoiding a computationally prohibitive exhaustive search, we solve our data detectors using sphere decoding (SD) and V-BLAST and provide simple adaptations of the SD algorithm. We consider how the blind detector performs under mismatch, generalize the basic data detectors to nonunitary constellations, and extend them to systems with pilots and virtual carriers. Simulations show that our data detectors perform well

Crystal\u27s Making a point: The persnickety story of English punctuation (Book Review)

A review of Crystal, D. (2015). Making a point: The persnickety story of English punctuation. New York: St. Martin’s Press. 378 pp. $24.99. ISBN 978125006041

Heat shock transcription factor 1 preserves cardiac angiogenesis and adaptation during pressure overload

To examine how heat shock transcription factor 1 (HSF1) protects against maladaptive hypertrophy during pressure overload, we subjected HSF1 transgenic (TG), knockout (KO) and wild type (WT) mice to a constriction of transverse aorta (TAC), and found that cardiac hypertrophy, functions and angiogenesis were well preserved in TG mice but were decreased in KO mice compared to WT ones at 4 weeks, which was related to HIF-1 and p53 expression. Inhibition of angiogenesis suppressed cardiac adaptation in TG mice while overexpression of angiogenesis factors improved maladaptive hypertrophy in KO mice. In vitro formation of vasculatures by microvascular endothelial cells was higher in TG mice but lower in KO mice than in WT ones. A siRNA of p53 but not a HIF-1 gene significantly reversed maladaptive hypertrophy in KO mice whereas a siRNA of HIF-1 but not a p53 gene induced maladaptive hypertrophy in TG mice. Heart microRNA analysis showed that miR-378 and miR-379 were differently changed among the three mice after TAC, and miR-378 or siRNA of miR-379 could maintain cardiac adaptation in WT mice. These results indicate that HSF1 preserves cardiac adaptation during pressure overload through p53-HIF-1-associated angiogenesis, which is controlled by miR-378 and miR-379