A study of methods to predict and measure the transmission of sound through the walls of light aircraft

The objectives are: measurement of dynamic properties of acoustical foams and incorporation of these properties in models governing three-dimensional wave propagation in foams; tests to measure sound transmission paths in the HP137 Jetstream 3; and formulation of a finite element energy model. In addition, the effort to develop a numerical/empirical noise source identification technique was completed. The investigation of a design optimization technique for active noise control was also completed. Monthly progress reports which detail the progress made toward each of the objectives are summarized

Efficacy of imidacloprid 10%/moxidectin 1% spot-on formulation (Advocate®) in the prevention and treatment of feline aelurostrongylosis

Background: In three randomized, controlled laboratory efficacy studies, the efficacy in the prevention of patent infections of a topical combination of imidacloprid 10%/moxidectin 1% (Advocate® spot-on formulation for cats, Bayer Animal Health GmbH) against larval stages and immature adults of Aelurostrongylus abstrusus, as well as the treatment efficacy of a single or three monthly treatments against adult A. abstrusus, were evaluated. Methods: Cats were experimentally inoculated with 300–800 third-stage larvae (L3). Each group comprised 8 animals and the treatment dose was 10 mg/kg bodyweight (bw) imidacloprid and 1 mg/kg bw moxidectin in each study. Prevention of the establishment of patent infections was evaluated by two treatments at a monthly interval at three different time points before and after challenge infection. Curative efficacy was tested by one or three treatments after the onset of patency. Worm counts at necropsy were used for efficacy calculations. Results: In Study 1, the control group had a geometric mean (GM) of 28.8 adult nematodes and the single treatment group had a GM of 3.4 (efficacy 88.3%). In Study 2, the control group had a GM of 14.3, the prevention group had a GM of 0 (efficacy 100%), while the treatment group had a GM of 0.1 (efficacy 99.4%). In Study 3, the GM worm burden in the control group was 32.6 compared to 0 in all three prevention groups (efficacy 100% for all of those groups). Conclusions: The monthly administration of Advocate® reliably eliminated early larval stages and thereby prevented lung damage from and patent infections with A. abstrusus in cats. Regarding treatment, a single application of Advocate® reduced the worm burden, but it did not sufficiently clear the infection. In contrast, three monthly treatments were safe and highly efficacious against A. abstrusus

The supernova-regulated ISM. II. The mean magnetic field

The origin and structure of the magnetic fields in the interstellar medium of spiral galaxies is investigated with 3D, non-ideal, compressible MHD simulations, including stratification in the galactic gravity field, differential rotation and radiative cooling. A rectangular domain, 1x1x2 kpc^{3} in size, spans both sides of the galactic mid-plane. Supernova explosions drive transonic turbulence. A seed magnetic field grows exponentially to reach a statistically steady state within 1.6 Gyr. Following Germano (1992) we use volume averaging with a Gaussian kernel to separate magnetic field into a mean field and fluctuations. Such averaging does not satisfy all Reynolds rules, yet allows a formulation of mean-field theory. The mean field thus obtained varies in both space and time. Growth rates differ for the mean-field and fluctuating field and there is clear scale separation between the two elements, whose integral scales are about 0.7 kpc and 0.3 kpc, respectively.Comment: 5 pages, 10 figures, submitted to Monthly Notices Letter

South Dakota Diversity of Temperature: Pictures from Statistical Analysis

The regional diversity of monthly temperature was analyzed based on long-term data obtained for South Dakota (SD) from the High Plains Regional Climate Center. Multidimensional statistical methods were used and the principal results presented as a sequence of 2- and 3-dimensional scatterplot pictures depicting the quantitative results. 
System hierarchical model of landscape was used for research tasks formulation. Initial matrixes for three research tasks were compiled for the state. The first set of initial matrices of time series {Xt*n}, where t = number of years and n = number of meteorological stations, contains two matrixes: X1(67*29) and X2(33*94). The second set -{Xt*m}, where t = number of years and m = number of months in a year: X3(113*12), X4(110*12), and X5(102*12). The third set - {Xn*m}, where n = number of meteorological stations and m = number of months in a year, contains two matrixes: X6(29*12) and X7(94*12). 
Statistical analysis allowed us to differentiate weather stations by temporal trends and spatial distribution for the time interval 1932-1998. The most variable stations (Brookings, Camp Crook, and Highmore) were determined; their seasonality was described (the most variable months and correlation among months during the year) and their seasonal regime determined. The average annual and monthly temperature distributions were presented for South Dakota based on 29 and 94 stations for the time intervals 1932-1998 and 1963-1995.
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The Effect of Combined Magnetic Geometries on Thermally Driven Winds I: Interaction of Dipolar and Quadrupolar Fields

Cool stars with outer convective envelopes are observed to have magnetic fields with a variety of geometries, which on large scales are dominated by a combination of the lowest order fields such as the dipole, quadrupole and octupole modes. Magnetised stellar wind outflows are primarily responsible for the loss of angular momentum from these objects during the main sequence. Previous works have shown the reduced effectiveness of the stellar wind braking mechanism with increasingly complex, but singular, magnetic field geometries. In this paper, we quantify the impact of mixed dipolar and quadrupolar fields on the spin-down torque using 50 MHD simulations with mixed field, along with 10 of each pure geometries. The simulated winds include a wide range of magnetic field strength and reside in the slow-rotator regime. We find that the stellar wind braking torque from our combined geometry cases are well described by a broken power law behaviour, where the torque scaling with field strength can be predicted by the dipole component alone or the quadrupolar scaling utilising the total field strength. The simulation results can be scaled and apply to all main-sequence cool stars. For Solar parameters, the lowest order component of the field (dipole in this paper) is the most significant in determining the angular momentum loss.Comment: 15 pages + 9 figures (main), 3 pages + 1 figure (appendix), accepted for publication to Ap

Air mass factor formulation for spectroscopic measurements from satellites: Application to formaldehyde retrievals from the Global Ozone Monitoring Experiment

Abstract. We present a new formulation for the air mass factor (AMF) to convert slant column measurements of optically thin atmospheric species from space into total vertical columns. Because of atmospheric scattering, the AMF depends on the vertical distribution of the species. We formulate the AMF as the integral of the relative vertical distribution (shape factor) of the species over the depth of the atmosphere, weighted by altitudedependent coefficients (scattering weights) computed independently from a radiative transfer model. The scattering weights are readily tabulated, and one can then obtain the AMF for any observation scene by using shape factors from a three dimensional (3-D) atmospheric chemistry model for the period of observation. This approach subsequently allows objective evaluation of the 3-D model with the observed vertical columns, since the shape factor and the vertical column in the model represent two independent pieces of information. We demonstrate the AMF method by using slant column measurements of formaldehyde at 346 nm from the Global Ozone Monitoring Experiment satellite instrument over North America during July 1996. Shape factors are computed with the Global Earth Observing System CHEMistry (GEOS-CHEM) global 3-D model and are checked for consistency with the few available aircraft measurements. Scattering weights increase by an order of magnitude from the surface to the upper troposphere. The AMFs are typically 20-40 % less over continents than over the oceans and are approximately half the values calculated in the absence of scattering. Model-induced errors in the AMF are estimated to be • 10%. The GEOS-CHEM model captures 50 % and 60 % of the variances in the observed slant and vertical columns, respectively. Comparison of the simulated and observed vertical columns allows assessment of model bias. 1

Innovative Drug Delivery and Formulation Designs To Deter Drug Abuse/Misuse Related To Suicide

Patients with a history of abuse/misuse of pain and psychotic medications are at high risk for suicide. Novel drug delivery and formulation approaches have been explored to reduce the potential of drug abuse/misuse and to improve patient compliance. This chapter reviews the design and mechanism of five successful products in the opioid and anti-psychotic categories. Embeda™ is an extended release capsule containing morphine pellets with a sequestered core of naltrexone; naltrexone acts as an aversive agent and is released only when the product is crushed. Remoxy® is an extended release oxycodone capsule with a highly viscous liquid fill content which is resistant to most common methods of tampering. Suboxone® is a sublingual tablet or film strip of buprenorphine with naloxone as an aversive agent; naloxone has poor sublingual/oral bioavailability and does not exert its activity unless the product is abused by the injectable route. Risperidal® Consta®, is a biweekly intramuscular injection of risperidone based on a biodegradable polymer microsphere technology. Invega® Sustenna® is a once-monthly intramuscular injection of paliperidone based on the water insoluble prodrug approach. The review of these five new drug products showcases the novel formulation tools and technologies available to deter drug abuse/misuse in patients who are at high risk of suicide

Amplitudes of low frequency modes in rotating B type stars

Using weakly non-linear theory of oscillation, we estimate the amplitudes of low frequency modes in a slowly pulsating B (SPB) star, taking account of the effects of rotation on the modes. Applying the formulation by Schenk et al (2002), we compute non-linear coupling coefficient between the low frequency modes and estimate the equilibrium amplitudes of the modes excited in the star, assuming the amplitudes of the unstable modes are saturated as a result of non-linear coupling with stable modes, that is, as a result of parametric instability expected between one unstable mode and two stable modes. We use the traditional approximation to calculate adiabatic and non-adiabatic oscillations in a rotating star. We find $r$-modes in a rapidly rotating star play a significant role in the amplitude determination through non-linear coupling. We also find that for low $m$ modes, the fractional amplitudes of the radiative luminosity caused by the low frequency modes are of order $10^{-4}$ to $10^{-3}$ at the surface.Comment: 14 pages, 6 figures, submitted to Monthly Notices of the Royal Astronomical Societ