Gene variants with suicidal risk in a sample of subjects with chronic migraine and affective temperamental dysregulation

BACKGROUND: Risk factors for suicide are at least partially heritable and functional polymorphisms of targeted genes have been suggested to be implicated in the pathogenesis of this phenomenon. However, other studies examining the association between specific gene variants and suicide revealed inconsistent findings. We aims to evaluate the possible association between MAO-A3, CYP1A2*1F and GNB3 gene variants, hopelessness and suicidal risk in a sample of subjects with chronic migraine and affective temperamental dysregulation. METHODS: 56 women were genotyped for MAO-A3, CYP1A2*1F and GNB3 gene variants. Participants were also assessed using Beck Hopelessness Scale (BHS), the Temperament Evaluation of the Memphis, Pisa, Paris and San Diego-Autoquestionnaire (TEMPS-A), and the Suicidal History Self-Rating Screening Scale (SHSS). RESULTS: Patients with higher total scores on affective dysregulated temperaments are more likely to have higher BHS (11.27 +/- 5.54 vs. 5.73 +/- 3.81; t19.20 = -3.57; p = 9 indicating high levels of hopelessness. No association was found between MAO-A3, CYP1A2*1F and GNB3 gene variants and suicidal risk as assessed by BHS and SHSS. CONCLUSIONS: This study did not sustain the association between MAO-A3, CYP1A2*1F and GNB3 gene variants and increased suicidal risk in patients with chronic migraine and affective temperamental dysregulation. Further studies investigating the gene-environment interaction or focusing on other genetic risk factors involved in suicidal behaviour are needed

Systematic analysis of the DJ(2580)D_{J}(2580), DJ∗(2650)D_{J}^{*}(2650), DJ(2740)D_{J}(2740), DJ∗(2760)D_{J}^{*}(2760), DJ(3000)D_{J}(3000) and DJ∗(3000)D_{J}^{*}(3000) in DD meson family

In this work, we tentatively assign the charmed mesons $D_{J}(2580)$, $D_{J}^{*}(2650)$, $D_{J}(2740)$, $D_{J}^{*}(2760)$, $D_{J}(3000)$ and $D_{J}^{*}(3000)$ observed by the LHCb collaboration according to their spin-parity and masses, then study their strong decays to the ground state charmed mesons plus light pseudoscalar mesons with the $^{3}P_{0}$ model. According to these study, we assigned the $D_{J}^{*}(2760)$ as the $1D\frac{5}{2}3^{-}$ state, the $D_{J}^{*}(3000)$ as the $1F\frac{5}{2}2^{+}$ or $1F\frac{7}{2}4^{+}$ state, the $D_{J}(3000)$ as the $1F\frac{7}{2}3^{+}$ or $2P\frac{1}{2}1^{+}$ state in the $D$ meson family. As a byproduct, we also study the strong decays of $2P\frac{1}{2}0^{+}$,$2P\frac{3}{2}2^{+}$, $3S\frac{1}{2}1^{-}$, $3S\frac{1}{2}0^{-}$ etc, states, which will be helpful to further experimentally study mixings of these $D$ mesons.Comment: 16 pages,1 figure. arXiv admin note: text overlap with arXiv:0801.4821 by other author

Inhibitors of \u3cem\u3eN\u3csup\u3eα\u3c/sup\u3e\u3c/em\u3e-acetyl-l-ornithine Deacetylase: Synthesis, Characterization and Analysis of their Inhibitory Potency

A series of N α-acyl (alkyl)- and N α-alkoxycarbonyl-derivatives of l- and d-ornithine were prepared, characterized, and analyzed for their potency toward the bacterial enzyme N α-acetyl-l-ornithine deacetylase (ArgE). ArgE catalyzes the conversion of N α-acetyl-l-ornithine to l-ornithine in the fifth step of the biosynthetic pathway for arginine, a necessary step for bacterial growth. Most of the compounds tested provided IC50 values in the μM range toward ArgE, indicating that they are moderately strong inhibitors. N α-chloroacetyl-l-ornithine (1g) was the best inhibitor tested toward ArgE providing an IC50 value of 85 μM while N α-trifluoroacetyl-l-ornithine (1f), N α-ethoxycarbonyl-l-ornithine (2b), and N α-acetyl-d-ornithine (1a) weakly inhibited ArgE activity providing IC50 values between 200 and 410 μM. Weak inhibitory potency toward Bacillus subtilis-168 for N α-acetyl-d-ornithine (1a) and N α-fluoro- (1f), N α-chloro- (1g), N α-dichloro- (1h), and N α-trichloroacetyl-ornithine (1i) was also observed. These data correlate well with the IC50 values determined for ArgE, suggesting that these compounds might be capable of getting across the cell membrane and that ArgE is likely the bacterial enzymatic target

Non-degenerate light quark masses from 2+1f lattice QCD+QED

We report on a calculation of the effects of isospin breaking in Lattice QCD+QED. This involves using Chiral Perturbation Theory with Electromagnetic corrections to find the renormalized, non-degenerate, light quark masses. The calculations are carried out on QCD ensembles generated by the RBC and UKQCD collaborations using Domain Wall Fermions and the Iwasaki and Iwasaki+DSDR Gauge Actions with unitary pion masses down to 170 MeV. Non-compact QED is treated in the quenched approximation. The simulations use a $32^3$ lattice size with $a^{-1}=2.28(3)$ GeV (Iwasaki) and 1.37(1) (Iwasaki+DSDR). This builds on previous work from the RBC/UKQCD collaboration with lattice spacing $a^{-1}=1.78(4)$ GeV.Comment: Presented at the 31st International Symposium on Lattice Field Theory (Lattice 2013), 29 July - 3 August 2013, Mainz, German

Generalized Hilbert Operators

If $g$ is an analytic function in the unit disc \D we consider the generalized Hilbert operator \hg defined by {equation*}\label{H-g} \mathcal{H}_g(f)(z)=\int_0^1f(t)g'(tz)\,dt. {equation*} We study these operators acting on classical spaces of analytic functions in \D . More precisely, we address the question of characterizing the functions $g$ for which the operator \hg is bounded (compact) on the Hardy spaces $H^p$, on the weighted Bergman spaces $A^p_\alpha$ or on the spaces of Dirichlet type $\mathcal D^p_\alpha$

Implications between approximate convexity properties and approximate Hermite-Hadamard inequalities

In this paper, the connection between the functional inequalities $$f\Big(\frac{x+y}{2}\Big)\leq\frac{f(x)+f(y)}{2}+\alpha_J(x-y) \qquad (x,y\in D)$$ and $$\int_0^1f\big(tx+(1-t)y\big)\rho(t)dt \leq\lambda f(x)+(1-\lambda)f(y) +\alpha_H(x-y) \qquad (x,y\in D)$$ is investigated, where $D$ is a convex subset of a linear space, $f:D\to\R$, $\alpha_H,\alpha_J:D-D\to\R$ are even functions, $\lambda\in[0,1]$, and $\rho:[0,1]\to\R_+$ is an integrable nonnegative function with $\int_0^1\rho(t)dt=1$