Antioxidant Activity and Oxidation Products of 1,2,3,4- Tetrahydroquinoxalines in Peroxyl Radical Scavenging Reactions, Part I

This paper studies the antioxidant activity of 1,2,3,4-tetrahydroquinolines, 3,4-dihydro-2H-benzo[1,4]thiazines and 1,2,3,4-tetrahydroquinoxalines in the inhibition of the peroxidation of tetralin induced by an azo initiator. Neither 1,2,3,4- tetrahydroquinoline nor 3,4-dihydro-2H-benzo[1,4]thiazine alone acted as an antioxidant, but when they have an electron-donating group at the para position to the NH group, they act as potent antioxidants. On the other hand, 1,2,3,4- tetrahydroquinoxaline on its own showed good antioxidant activity. However, 1,2,3,4-tetrahydroquinoxalines with methyl and methoxy groups in the phenyl ring have reactivities similar to or less than that of unsubstituted 1,2,3,4-tetrahydroquinoxaline. The induction periods of 1,2,3,4-tetrahydroquinoxalines with an alkyl group or phenyl group at the 2-position were all longer than the value for the unsubstituted 1,2,3,4-tetrahydroquinoxaline, except for a compound with a t-butyl group. The oxidation of 1,2,3,4-tetrahydroquinoxalines by peroxyl radicals generated from an azo initiator in tetralin or benzene yields quinoxalines and a dimer product of quinoxalines, 6-(1,2,3,4-tetrahydroquinoxalin-1-yl)-quinoxaline

Relaxation and 3d-2d passage with determinant type constraints: an outline

We outline our work (see [1,2,3,4]) on relaxation and 3d-2d passage with determinant type constraints. Some open questions are addressed. This outline-paper comes as a companion to [5]

Off-shell supergravity-matter couplings in three dimensions

We develop the superspace geometry of N-extended conformal supergravity in three space-time dimensions. General off-shell supergravity-matter couplings are constructed in the cases N=1,2,3,4.Comment: 73 pages; V5: typos in eqs. (3.4b), (3.17) and (4.24) correcte

Functionalized Ruthenatricarbadecaborane via Selective Cage Iodination and Sonogashira Coupling Reactions

Selective iodination of the cyclopentadienylruthenium tricarbadecaboranyl complexes 1-(η5-C5H5)–2-Ph–closo-1,2,3,4-RuC3B7H9 (1) and 1-(η5-C5(CH3)5)–2-Ph–closo-1,2,3,4-RuC3B7H8 (2) to form their mono-iodo derivatives, 1-(η5-C5H5)–2-Ph–6-I–closo-1,2,3,4-RuC3B7H9 (3) and 1-(η5-C5(CH3)5)–2-Ph–6-I–closo-1,2,3,4-RuC3B7H8(4), was achieved in 90% yields by their reactions with ICl in CH2Cl2 solutions. Also isolated in trace amounts from the reaction with 2 was the di-iodo 1-(η5-C5(CH3)5)–2-Ph–6,11-I2–closo-1,2,3,4-RuC3B7H7, (5) complex. The sonication-promoted Sonogashira coupling reaction of 3 with terminal acetylenes catalyzed by Pd(dppf)Cl2/CuI yielded the functionalized ruthenatricarbadecaboranyl complexes 1-(η5-C5H5)–2-Ph–6-(Ph-C≡C)–closo-1,2,3,4-RuC3B7H8 (6), 1-(η5-C5H5)–2-Ph–6-[CH3CH2C(O)OCH2-C≡C]–closo-1,2,3,4-RuC3B7H8 (7), 1-(η5-C5H5)–2-Ph–6-[(η5-C5H5)Fe(η5-C5H4)-C≡C]–closo-1,2,3,4-RuC3B7H8 (8) and 1-(η5-C5H5)–2-Ph–6-[(CH3)3Si-C≡C]–closo-1,2,3,4-RuC3B7H8 (9). These reactions thus provide a versatile, systematic pathway for the syntheses of a wide variety of new types of functionalized ruthenatricarbadecaboranyl complexes

Di-, Hexa- and Deca-Substituted Decaphenylferrocenes

5-Bromo-1,2,3,4-tetraphenyl-5-p-tolyl-1,3-cyclopentadiene (1a), 5-Bromo-1,4-di-phenyl-2,3,5- tri-p-tolyl-1,3-cyclopentadiene (1b), 5-Bromo-1,2,3,4,5-penta-p-tolyl-1,3-cyclopentadiene (1c), 5- Bromo-1,2,3,4-tetraphenyl-5-p-bromophenyl-1,3-cyclopentadiene (1d), and 5-Bromo-1,2,3,4-tetraphenyl- 5-p-anisyl-1,3-cyclopentadiene (1e) react with ironpentacarbonyl in m-xylene to yield the corresponding ferrocenes 2a - 2e. In the course of the purification procedure, reactions with HCl and the solvent m-xylene are observed which yield the mixed ionic sandwich complexes [(C5Ph4C6H4Me)Fe(C6H4Me2)]+Cl− (3a), [(C5Ph2(C6H4Me)3)Fe(C6H4Me2)]+Cl− (3b), [(C5(C6H4Me)5)Fe(C6H4Me2)]+Cl− (3c), [(C5Ph4C6H4Br)Fe(C6H4Me2)]+Cl− (3d), and [(C5Ph4 C6H4OMe)Fe(C6H4Me2)]+Cl− (3e), respectively, along with the corresponding cyclopentadienes 1,2,3,4-tetraphenyl-5-p-tolyl-1,3-cyclopentadiene (4a), 1,4-diphenyl-2,3,5-tri-p-tolyl-1,3- cyclopentadiene (4b), 1,2,3,4,5-penta-p-tolyl-1,3-cyclopentadiene (4c), 1,2,3,4-tetraphenyl-5-pbromphenyl- 1,3-cyclopentadiene (4d), and 1,2,3,4-tetraphenyl-5-p-anisyl-1,3-cyclopentadiene (4e). The compounds have been characterized by elemental analysis, IR, NMR, and mass spectra, and, in the case of 2c, by 13C-CPMAS spectroscopy and X-ray powder diffractometry

Sinteza, karakterizacija i antimikrobni učinak derivata karbazola

The reaction of 1-oxo-1,2,3,4-tetrahydrocarbazoles (1a-e) with paraformaldehyde and ethylenediamine yielded N,N\u27-bis(1,2,3,4-tetrahydrocarbazol-1-ylidene)ethane-1,2-diamines (2a-e). Here, like in another similar attempt of replacing ethylenediamine by ethanolamine, ended up in formation of 2-{[1-(2-(2-aminoethoxy)ethylimino)-1,2,3,4-tetrahydrocarbazol-2-yl-methyl]amino}ethanols (3a-e). These products were characterized by IR, 1H NMR, mass spectra and by elemental analysis. All end products (2a-e, 3a-e) were screened for antibacterial and antifungal activities. The compounds having substituents at C-6 position were found to exhibit pronounced antimicrobial activities.Reakcijom 1-okso-1,2,3,4-tetrahidrokarbazola (1a-e) s paraformaldehidom i etilendiaminom dobiveni su N,N’-bis(1,2,3,4-tetrahidrokarbazol-1-iliden)etan-1,2-diamini (2a-e). Ovdje su, kao i u drugim sličnim pokušajima zamjene etilendiamina etanolaminom, nastali derivati 2-{[1-(2-(2-aminoetoksi)etilimino)-1,2,3,4-tetrahidrokarbazol-2-il-metil]amino} etanola (3a-e). Spojevi su karakterizirani pomoću IR, 1H NMR i masenom spektrometrijom te elementarnom analizom. Ispitano je antibakterijsko i antimikotsko djelovanje produkata 2a-e i 3a-e. Spojevi sa supstituentima u položaju C-6 imaju izraženo antimikrobno djelovanje

Isolation and X-ray crystal structure of tetrahydroisoquinoline alkaloids from Calycotome villosa Subsp. intermedias

Two tetrahydroisoquinoline alkaloids were extracted from the alkaloid fraction of a methanol extract of the seeds of Calycotome Villosa Subsp. intermedia. Their structures were established as (R)-1-hydroxymethyl-7-8-dimethoxy-1,2,3,4-tetrahydro- isoquinoline (1) and (S)-7-hydroxymethyl-2-3-dimethoxy-7,8,9,10-tetrahydroisoquinoline chloride (2) by spectroscopic techniques and X-ray diffraction analysis

Brane solitons of (1,0) superconformal theories in six dimensions with hypermultiplets

We solve the Killing spinor equations of 6-dimensional (1,0) superconformal theories which include hyper-multiplets in all cases. We show that the solutions preserve 1,2,3,4 and 8 supersymmetries. We find models with self-dual string solitons which are smooth and supported by instantons with an arbitrary gauge group, and 3-brane solitons as expected from the M-brane intersection rules.Comment: 13 page