Transcranial Magnetic Stimulation in the Treatment of Tinnitus

Tinnitus is a disturbing noise that is heard without any hearing stimulus, affects the quality of life of the individual, and leads to psychosocial problems. Its prevalence characteristically increases with aging. It is seen in 33% of the general population. Pathophysiology of tinnitus known to accompany nearly all disorders in auditory system has not been fully understood; therefore, there are some difficulties in evaluation and treatment thereof. Despite the restrictive factors of tinnitus treatment, progress in auditory neuroscience provides a positive view of tinnitus treatment. Transcranial magnetic stimulation (TMS) is a method based on the stimulation of neuronal tissue without depending on the transfer of electrical current by means of electrodes or the skin. TMS is used in the treatment of various diseases with developing neuroscience. In the recent years, the number of studies on TMS application with repetitive low frequency for the treatment of tinnitus has increased, and most of these studies have given successful results. Repetitive use of TMS in tinnitus is very novel; however, it is commonly used in psychiatric disorders, especially in the treatment of drug-resistant depression. The chapter shows that low-frequency repetitive TMS (rTMS) is useful in the treatment of chronic tinnitus

Meniere’s Disease: Nonsurgical Treatment

Meniere’s disease or syndrome is one of the most common inner ear diseases. Meniere’s disease is characterized by episodic vertigo, sensorineural hearing loss that fluctuates during episodes, tinnitus, and ear fullness. Ideal treatment should stop vertigo attacks, restore hearing, get rid of tinnitus and ear fullness. Treatment options are decided upon the remaining hearing, severity, and intensity of vertigo attacks. Meniere’s disease is progressive on hearing levels of the patient; some of them develop profound hearing loss that also could affect the other ear. In order to plan a treatment scheme for patient, these conditions should be assessed. It has a destructive and progressive nature, so the first step of treatment should contain more conservative treatment options. If symptom control could not be obtained, destructive treatment options should be considered

Jet quenching in heavy-ion collisions at LHC with CMS detector

Thesis (Ph. D.)--Massachusetts Institute of Technology, Dept. of Physics, 2013.Cataloged from PDF version of thesis.Includes bibliographical references (pages 143-148).The collision of highly relativistic nuclei can produce a volume of high energy density which can be used to learn about the behavior of quantum chromodynamics (QCD) at extreme conditions, such as those of the universe at times before and during the formation of hadrons out of quarks and gluons. This thesis presents experimental studies of jet-quenching phenomena in PbPb collisions at [square root of]sNN = 2.76 TeV, with a focus on the study of the energy-loss, namely the analysis of correlations of jet pairs as measured by the CMS detector at LHC. The implications of the results are discussed by comparison of simple models with data. It is observed that the geometrical configuration of the dijets and the nuclear collision region plays an important role in the correlations between the jets, and the set of CMS results reviewed can illustrate the dependence of the amount of lost energy on the length of the traversed medium.by Yetkin Yilmaz.Ph.D

Meniere’s Disease: Surgical Treatment

When Meniere’s disease’s vertigo attacks are too frequent and medical treatment options fail, surgical treatment options should be considered. Meniere’s disease is progressive, and there is not a known cure, and all treatment options are symptomatic. Also the possibility of bilateral involvement is another well-known characteristic of this condition as well as its effect on hearing. Some of the patients have progressive hearing loss with vertigo attacks. In order to decide a surgical procedure for these patients, clinicians must be aware of the natural course of Meniere’s disease. In order to their effects on vestibular system, there are two types of surgical procedures. Nondestructive surgeries aim to alter the course of disease, and destructive surgeries aim to control symptoms while eliminating all vestibular functions of the effected ear

Jet Fragmentation Functions Measured in PbPb Collisions with CMS

The energy loss of partons in high-energy nuclear collisions is one of the most interesting observables to probe the nature of the produced medium. Analyzing data from PbPb collisions at a center-of-mass energy of 2.76 TeV, recorded with the Compact Muon Solenoid (CMS) detector, parton energy loss is observed as a significant imbalance of dijet transverse momentum. To gain further understanding of the parton energy loss mechanism and how it manifests itself in the distribution of final state particles, fragmentation functions are studied for the leading and subleading jet in bins of dijet imbalance.Comment: 1 cover + 4 pages, 3 figures (with 5 source figures). Quark Matter 2011 conference report. To be published in special issue of J. Phys. G: Nucl. Part. Phy

Perifosine and vitamin D combination induces apoptotic and non-apoptotic cell death in endometrial cancer cells

Endometrial cancer is the most common cancer of the female reproductive system. Combination treatment with specific agents has been widely used as a targeted therapy for cancer. In this study, we aimed to investigate the anti-proliferative and apoptotic effects of varying concentrations of perifosine and vitamin D on the human endometrial cancer cell line (HEC-1A). HEC-1A cells were exposed to perifosine (10 μM, 30 μM), vitamin D (50 nM, 200 nM) and combinations of both for 48 h and 72 h. Monitoring of cell proliferation in a time-dependent manner was performed with the xCELLigence RTCA DP system. The levels of BCL2, BAX and P53 mRNA expression were examined using RT-qPCR. Apoptosis was determined using Annexin V, which were followed by flow cytometry analysis. Ultra-structural morphology of cells was analyzed by transmission electron microscopy (TEM) for 72 h. The anti-proliferative and apoptotic effects of the perifosine+vitamin D combination (30 μM + 200 nM at 48 h and 10 μM + 200 nM at 72 h) on HEC-1A cells were higher than in perifosine and vitamin D alone. It was observed that perifosine has increased the expression of BAX mRNA in HEC-1A cells in a dose-dependent manner. While perifosine+vitamin D combinations increased P53 mRNA expression in HEC-1A cells we did not find any significant change in BCL2, BAX mRNA expression levels. In TEM examinations of HEC-1A cells, perifosine appeared to lead autophagic cell death, whereas vitamin D caused paraptosis-like cell death and combination of perifosine+vitamin D caused apoptotic and non-apoptotic (paraptotic, autophagic and necrotic) cell death. Therefore, it is considered that the combination of both drugs in the treatment of endometrial cancer might be an alternative and effective treatment option through activating the apoptotic and non-apoptotic cell death mechanisms in cancer cells

Track reconstruction at LHC as a collaborative data challenge use case with RAMP

Charged particle track reconstruction is a major component of data-processing in high-energy physics experiments such as those at the Large Hadron Collider (LHC), and is foreseen to become more and more challenging with higher collision rates. A simplified two-dimensional version of the track reconstruction problem is set up on a collaborative platform, RAMP, in order for the developers to prototype and test new ideas. A small-scale competition was held during the Connecting The Dots / Intelligent Trackers 2017 (CTDWIT 2017) workshop. Despite the short time scale, a number of different approaches have been developed and compared along a single score metric, which was kept generic enough to accommodate a summarized performance in terms of both efficiency and fake rates

Measurement of the charge ratio of atmospheric muons with the CMS detector

We present a measurement of the ratio of positive to negative muon fluxes from cosmic ray interactions in the atmosphere, using data collected by the CMS detector both at ground level and in the underground experimental cavern at the CERN LHC. Muons were detected in the momentum range from 5 GeV/c to 1 TeV/c . The surface flux ratio is measured to be 1.2766±0.0032(stat.)±0.0032(syst.), independent of the muon momentum, below 100 GeV/c. This is the most precise measurement to date. At higher momenta the data are consistent with an increase of the charge ratio, in agreement with cosmic ray shower models and compatible with previous measurements by deep-underground experiments.United States. Dept. of EnergyNational Science Foundation (U.S.)Alfred P. Sloan Foundatio