Integrating Spatial Working Memory and Remote Memory: Interactions between the Medial Prefrontal Cortex and Hippocampus

In recent years, two separate research streams have focused on information sharing between the medial prefrontal cortex (mPFC) and hippocampus (HC). Research into spatial working memory has shown that successful execution of many types of behaviors requires synchronous activity in the theta range between the mPFC and HC, whereas studies of memory consolidation have shown that shifts in area dependency may be temporally modulated. While the nature of information that is being communicated is still unclear, spatial working memory and remote memory recall is reliant on interactions between these two areas. This review will present recent evidence that shows that these two processes are not as separate as they first appeared. We will also present a novel conceptualization of the nature of the medial prefrontal representation and how this might help explain this area’s role in spatial working memory and remote memory recall

COMPTEL solar flare measurements

We review some of the highlights of the COMPTEL measurements of solar flares. These include images of the Sun in γ rays and neutrons. One of the important features of the COMPTEL instrument is its capability to measure weak fluxes of γ rays and neutrons in the extended phase of flares. These data complement the spectra taken with the COMPTEL burst spectrometer and the telescope during the impulsive phase of flares. We focus our attention on some of these general capabilities of the instrument and the latest results of two long‐duration γ‐ray flares, i.e., 11 and 15 June 199

The solar gamma ray and neutron capabilities of COMPTEL on the Gamma Ray Observatory

The imaging Compton telescope COMPTEL on the Gamma Ray Observatory (GRO) has unusual spectroscopic capabilities for measuring solar gamma-ray and neutron emission. The launch of the GRO is scheduled for June 1990 near the peak of the sunspot cycle. With a 30 to 40 percent probability for the Sun being in the COMPTEL field-of-view during the sunlit part of an orbit, a large number of flares will be observed above the 800 keV gamma-ray threshold of the telescope. The telescope energy range extends to 30 MeV with high time resolution burst spectra available from 0.1 to 10 MeV. Strong Compton tail suppression of instrumental gamma-ray interactions will facilitate improved spectral analysis of solar flare emissions. In addition, the high signal to noise ratio for neutron detection and measurement will provide new neutron spectroscopic capabilities. Specifically, a flare similar to that of 3 June 1982 will provide spectroscopic data on greater than 1500 individual neutrons, enough to construct an unambiguous spectrum in the energy range of 20 to 200 MeV. Details of the instrument and its response to solar gamma-rays and neutrons will be presented

Continuous Theta Rhythm During Spatial Working Memory Task in Rodent Models of Streptozotocin-induced Type 2 Diabetes

Alzheimer’s disease is a neurodegenerative disorder altering memory loss thought to be due to neuropathological symptoms such as the buildup of beta amyloid plaques (Ab) and neurofibrillary tangles (NFT). The etiology of Alzheimer’s is still unknown; however, potential risk factors such as diabetes may lead to its development. The most common form of diabetes is type 2 diabetes known for persistent insulin resistance leading to a state of hyperglycemia. Insulin resistance has been shown to affect cognitive abilities such as learning, memory and also alters synaptic plasticity. Neural connections between the hippocampus (HC) and anterior cingulate cortex (ACC) are known to be very important for learning and memory and are highly plastic, making them an intriguing target that could be altered by hyperglycemia. We hypothesize that hyperglycemic rodents will exhibit spatial memory deficits that may be associated with cognitively linked interactions between the HC and ACC. Minimal doses of streptozotocin (STZ), which is toxic to insulin producing beta cells, were given for 9-10 weeks. Using a spatial working memory task known as delayed alternation we found significant differences between control and experimental rats in working memory accuracy. This task places strong working memory demands on subjects which may be compromised by a hyperglycemic state. We measured EEG recordings from the HC and ACC during task performance and found that hyperglycemic rats had nearly continuous theta rhythm during the 30-minute session. Control rats however, displayed normal transitions between theta and lower frequency delta. Neural connectivity may be altered due to a change in frequency activity between the HC and ACC due to diabetes which is a risk factor in the development of AD impairments. These results show that hyperglycemia leads to changes along the circuit critical for learning and memory

Limits on violations of Lorentz Symmetry from Gravity Probe B

Generic violations of Lorentz symmetry can be described by an effective field theory framework that contains both general relativity and the standard model of particle physics called the Standard-Model Extension (SME). We obtain new constraints on the gravitational sector of the SME using recently published final results from Gravity Probe B. These include for the first time an upper limit at the 10^(-3) level on the time-time component of the new tensor field responsible for inducing local Lorentz violation in the theory, and an independent limit at the 10^(-7) level on a combination of components of this tensor field.Comment: 8 pages, 1 figur

Addressing Grief and Loss through the Continuum of Care: A Focus on Patient Experiences and Professional Practices

Grief and loss are universal parts of the human experience. They are also some of the most profound experiences that a human being encounters in life. In addiction treatment, grief and loss must be addressed in order for an individual to successfully journey into recovery. In recovery, individuals must have the skills to cope with grief and loss to successfully maintain their sobriety when life happens. Integrated grief and loss is the ultimate objective. Treatment should focus on “stuck points” without pathologizing the individual’s experience. This presentation is the beginning of a discussion about best practices when addressing grief and loss in addiction treatment and the types of interventions that have proven most successful

Hard x-ray polarimeter for gamma-ray bursts and solar flares

We report on the development of a dedicated polarimeter design that is capable of studying the linear polarization of hard X-rays (50-300 keV) from gamma-ray bursts and solar flares. This compact design, based on the use of a large area position-sensitive PMT (PSPMT), is referred to as GRAPE (Gamma-RAy Polarimeter Experiment). The PSPMT is used to determine the Compton interaction location within an array of small plastic scintillator elements. Some of the photons that scatter within the plastic scintillator array are subsequently absorbed by a small centrally-located array of CsI(Tl) crystals that is read out by an independent multi-anode PMT. One feature of GRAPE that is especially attractive for studies of gamma-ray bursts is the significant off-axis response (at angles \u3e 60 degrees). The modular nature of this design lends itself toward its accomodation on a balloon or spacecraft platform. For an array of GRAPE modules, sensitivity levels below a few percent can be achieved for both gamma-ray bursts and solar flares. Here we report on the latest results from the testing of a laboratory science model