1,575 research outputs found

    Racial Ethnic Equality in Child Well-Being from 1985-2004: Gaps Narrowing, but Persist

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    Analyzes changes in safety/behavioral concerns, family economic well-being, health, community connectedness, educational attainment, social relationships, and emotional/spiritual well-being by race and ethnicity. Tracks disparities between groups

    Young Children of Immigrants: The Leading Edge of America's Future

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    Highlights data on the population of children of immigrants up to age 8, distribution by state, parents' origins, school enrollment rates, English proficiency, and family characteristics, including parent's citizenship, education, and income level

    Children in Immigrant Families - The U.S. and 50 States: Economic Need Beyond the Official Poverty Measure

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    Analyzes gaps between child poverty rates in immigrant families and native-born families based on two alternative measures that take into account the costs of housing, food, other basic necessities, transportation, taxes, child care, and early education

    Children in Immigrant Families -- The U.S. and 50 States: National Origins, Language, and Early Education

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    Draws on new results of U.S. Census 2000 data to focus on children in immigrant families, highlighting the proportion, dispersion, national origins, language, and early education of children in newcomer families nationwide and in various states

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    A Profile of Immigrants in Arkansas

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    Discusses key demographic trends, economic factors, and public policy issues associated with immigrants in Arkansas, which has the fourth-fastest-growing immigrant population in the nation

    Ameliorating Systematic Uncertainties in the Angular Clustering of Galaxies: A Study using SDSS-III

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    We investigate the effects of potential sources of systematic error on the angular and photometric redshift, z_phot, distributions of a sample of redshift 0.4 < z < 0.7 massive galaxies whose selection matches that of the Baryon Oscillation Spectroscopic Survey (BOSS) constant mass sample. Utilizing over 112,778 BOSS spectra as a training sample, we produce a photometric redshift catalog for the galaxies in the SDSS DR8 imaging area that, after masking, covers nearly one quarter of the sky (9,913 square degrees). We investigate fluctuations in the number density of objects in this sample as a function of Galactic extinction, seeing, stellar density, sky background, airmass, photometric offset, and North/South Galactic hemisphere. We find that the presence of stars of comparable magnitudes to our galaxies (which are not traditionally masked) effectively remove area. Failing to correct for such stars can produce systematic errors on the measured angular auto-correlation function, w, that are larger than its statistical uncertainty. We describe how one can effectively mask for the presence of the stars, without removing any galaxies from the sample, and minimize the systematic error. Additionally, we apply two separate methods that can be used to correct the systematic errors imparted by any parameter that can be turned into a map on the sky. We find that failing to properly account for varying sky background introduces a systematic error on w. We measure w, in four z_phot slices of width 0.05 between 0.45 < z_phot < 0.65 and find that the measurements, after correcting for the systematic effects of stars and sky background, are generally consistent with a generic LambdaCDM model, at scales up to 60 degrees. At scales greater than 3 degrees and z_phot > 0.5, the magnitude of the corrections we apply are greater than the statistical uncertainty in w.Comment: Accepted by MNRA

    IKK phosphorylates Huntingtin and targets it for degradation by the proteasome and lysosome

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    Expansion of the polyglutamine repeat within the protein Huntingtin (Htt) causes Huntington's disease, a neurodegenerative disease associated with aging and the accumulation of mutant Htt in diseased neurons. Understanding the mechanisms that influence Htt cellular degradation may target treatments designed to activate mutant Htt clearance pathways. We find that Htt is phosphorylated by the inflammatory kinase IKK, enhancing its normal clearance by the proteasome and lysosome. Phosphorylation of Htt regulates additional post-translational modifications, including Htt ubiquitination, SUMOylation, and acetylation, and increases Htt nuclear localization, cleavage, and clearance mediated by lysosomal-associated membrane protein 2A and Hsc70. We propose that IKK activates mutant Htt clearance until an age-related loss of proteasome/lysosome function promotes accumulation of toxic post-translationally modified mutant Htt. Thus, IKK activation may modulate mutant Htt neurotoxicity depending on the cell's ability to degrade the modified species

    A Cautionary Tale: MARVELS Brown Dwarf Candidate Reveals Itself To Be A Very Long Period, Highly Eccentric Spectroscopic Stellar Binary

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    We report the discovery of a highly eccentric, double-lined spectroscopic binary star system (TYC 3010-1494-1), comprising two solar-type stars that we had initially identified as a single star with a brown dwarf companion. At the moderate resolving power of the MARVELS spectrograph and the spectrographs used for subsequent radial-velocity (RV) measurements (R ~ <30,000), this particular stellar binary mimics a single-lined binary with an RV signal that would be induced by a brown dwarf companion (Msin(i)~50 M_Jup) to a solar-type primary. At least three properties of this system allow it to masquerade as a single star with a very low-mass companion: its large eccentricity (e~0.8), its relatively long period (P~238 days), and the approximately perpendicular orientation of the semi-major axis with respect to the line of sight (omega~189 degrees). As a result of these properties, for ~95% of the orbit the two sets of stellar spectral lines are completely blended, and the RV measurements based on centroiding on the apparently single-lined spectrum is very well fit by an orbit solution indicative of a brown dwarf companion on a more circular orbit (e~0.3). Only during the ~5% of the orbit near periastron passage does the true, double-lined nature and large RV amplitude of ~15 km/s reveal itself. The discovery of this binary system is an important lesson for RV surveys searching for substellar companions; at a given resolution and observing cadence, a survey will be susceptible to these kinds of astrophysical false positives for a range of orbital parameters. Finally, for surveys like MARVELS that lack the resolution for a useful line bisector analysis, it is imperative to monitor the peak of the cross-correlation function for suspicious changes in width or shape, so that such false positives can be flagged during the candidate vetting process.Comment: 16 pages, 11 figures, 6 table
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