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journal article
oaidoi:10.1016/0014-5793(86)80561-0

Carbachol and oxytocin stimulate the generation of inositol phosphates in the guinea pig myometrium

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Publication date
26 May 1986
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Published by Elsevier B.V.
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    Abstract

    AbstractIn the guinea pig myometrium prelabelled with myo-[2-3H]inositol, carbachol and oxytocin enhanced a concentration-dependent and rapid release of IP3 which preceded that of IP2 and IP1. The specific receptor-mediated phospholipase C activation degrading PIP2 to IP3 did not require the presence of extracellular Ca2+. The ionophore A23187 as well as K+ depolarization failed to increase inositol phosphate accumulation. It is proposed that IP3 could have a role in the contraction of uterine smooth muscle elicited by the activation of muscarinic as well as of oxytocin receptors

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