Periprosthetic Joint Infection in Egypt: A Narrative Review of the Current Landscape and Knowledge Gaps

Abstract

Background: Periprosthetic joint infection (PJI) is one of the most serious complications of total joint arthroplasty (TJA). This review synthesizes the available local evidence of PJI in Egypt to identify the current landscape and knowledge gaps in the Egyptian healthcare system. Methods: A literature review was conducted by searching PubMed, Scopus, and Google Scholar for studies on PJI in Egypt, with articles published up to January 2026. Search terms included "periprosthetic joint infection," "PJI," "Arthroplasty," and "Egypt." We included 9 primary studies for synthesis and excluded review papers. Results: This paper summarizes PJI studies from Egypt and highlights the limited existing knowledge, specific local issues, and gaps. Main findings were limited epidemiological data indicating that rates of PJI in a key study appear higher than in high-income countries, with Staphylococci as the most common organism across studies. Critical gaps exist in national epidemiological data, risk factors, patient demographics, the detailed microbiological spectrum and antimicrobial resistance patterns, as well as long-term patient outcomes, and standardized national guidelines for diagnosis and management. Conclusion: Based on this review, there is limited local evidence on many aspects of PJI in Egypt. Our proposed priorities include further research into the highlighted gaps, the establishment of a national registry, the development of multidisciplinary care models, standardized antimicrobial prescribing protocols, and the implementation of evidence-based national guidelines tailored to the Egyptian healthcare system