Randomized Controlled Trial Evaluating Ovulation Response after Myo Inositol versus Metformin in Women with Polycystic Ovary Syndrome.

Abstract

Background: One of the most prevalent endocrine conditions affecting women of reproductive age is polycystic ovary syndrome (PCOS), which is a primary contributor to anovulatory infertility. One important factor in the pathophysiology of PCOS is insulin resistance. While myo-inositol has lately surfaced as a viable substitute for enhancing ovulatory function, metformin has long been utilized as an insulin sensitizer.  Objective: To compare the ovulation response of Myo-inositol and Metformin in women with PCOS.  Methods: Over the course of four months, 200 women with PCOS were included in a research trial. Two groups of one hundred each were randomly selected from among the participants. Group B was given 500 mg of metformin three times a day, while Group A was given 2 g of myo-inositol twice a day. Follicle monitoring and blood progesterone levels were used to track ovulation. Pregnancy rate, menstrual regularity, and ovulation rate were among the results. The chi-square test was used for statistical analysis, and p <0.05 was deemed statistically significant.  Results: Compared to 48% of women in the Metformin group, 62% of women in the Myo-inositol group experienced ovulation. Compared to 18% of women taking metformin, 28% of women taking myo-inositol became pregnant. Myo-inositol appeared to improve the difference in ovulation rate (p = 0.064). Although the Myo-inositol group had a greater pregnancy rate, the difference was not statistically significant (p = 0.13).  Conclusion:In women with PCOS, myo-inositol produced better ovulation and pregnancy outcomes than metformin. For PCOS patients, it can be regarded as an efficient and well-tolerated substitute for ovulation induction.  Recommendation: Myo-inositol may be considered a preferable first-line therapy for ovulation induction in women with polycystic ovary syndrome due to its favorable efficacy and tolerability profile