植物精油成分の駆虫作用に関する研究 第4報 化学構造との関係

Abstract

1. On the compounds related to volatile oils, correlation between the chemical structure and the potency against pig ascaris, earthworms and mice was discussed. 2. The stimulating action on earthworm muscles is not related with the chemical structure of compounds. 3. Ascaricidal action of Phenols is diminished by the introduction of an alkyl radical into the nucleus of phenols. Para-alkylphenol and meta-alkylphenol have the same potency against pig ascaris, though the later is much more toxic to mice than the former. 4. Thymol increases its ascaricidal potency by chlorination, but carvacrol does not. 5. Terpene alkohols, especially primary alkohols are much more toxic to pig ascaris as well as mice than terpene ketones. Ascaricidal action of alkylbenzenes and alkylcyclohexans with unsaturated side chains increases by hydrogenation of the side chains