Integrative Analysis of Oxidative Stress Biomarkers And Their ” Clinical correlates in Pediatric Type 1 Diabetes A Multi Parametric Approach

Abstract

In this study, we used the neutrophil granulocytes functional activity model to examine oxidative stress indicators, antioxidant protection, lipid peroxidation, and T1D in children. According to research, children with type 1 diabetes show heightened lipoperoxidation and antioxidant defense system activation in response to reactive oxygen species (ROS) damage, which includes bidirectional alterations in non-enzymatic pathways. The development of tolerance to oxidative stress in children with compensated type 1 diabetes is indicated by the coordinated synthesis of reactive oxygen species and oxygen-dependent blood cell metabolism. In children with decompensated type 1 diabetes, it is indicated that the third stage of oxidative stress, which involves the depletion of insulin-producing β-cells, begins with a decrease in reactive oxygen species production, a decrease in the activation of the phagocyte oxygen-dependent metabolism, and incomplete phagocytosis mechanisms. The severity of metabolic problems in children with type 1 diabetes is influenced by the level of the antioxidant defense system's "respiratory explosion" of neutrophilic granulocytes